Establishment of the first Chinese national standard for protein subunit SARS-CoV-2 vaccine중국 최초의 단백질 소단위 SARS-CoV-2 백신 국가표준 제정Article Published on 2022-03-252022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] accelerated addition Antigen Antigen content approved asked assigned Biological Biological product calibration China Chinese Committee contribute Control COVID-19 Degradation detect determined by drug ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibited expression food house Laboratory linear relationship National national standard potency produced product Protein subunit Quality control reference material reference standard Reference standards returned SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines stability target proteins Vaccine was performed [DOI] 10.1016/j.vaccine.2022.02.048 PMC 바로가기 [Article Type] Article
Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling화학 구조 및 생물학적 활성 기반 모델링을 사용한 Anti-SARS-CoV-2 화합물의 효율적인 식별Article Published on 2022-03-242022-09-11 Journal: Journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] 3CL acting anti-SARS-CoV-2 antiviral activities antiviral activity approach Biological characteristic Chemical chymotrypsin complementary Compound compound screening Drug discovery Efficiency efficient entry of SARS-CoV-2 expand experimental validation fold human host cell human host cells identification identify IMPROVE inhibitor Live virus machine learning model machine learning models modeling protease Protease inhibitor receiver receiver operating characteristic SARS-CoV-2 speed Structure the SARS-CoV-2 viral entry [DOI] 10.1021/acs.jmedchem.1c01372 PMC 바로가기 [Article Type] Article
Immune response to one dose of BNT162b2 mRNA Covid-19 vaccine followed by SARS-CoV-2 infection: An Italian prospective observational studyObservational Study Published on 2022-03-152022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] anti-SARS-CoV-2 Antibody Response Biological biological risk BNT162b2 mRNA vaccine carried categories control group COVID-19 dose European country first dose geometric mean titer GMT HCW HCWs Health healthcare worker Healthcare workers immunization immunized individual Infection initiated Italian Italy mRNA Observational cohort study of BNT162b2 positive PPE prospective observational study risk SARS-CoV-2 serological statistically significant difference surveillance data tested the antibody response the vaccine Two-arm vaccination Vaccinations Vaccine vaccine group was determined were infected [DOI] 10.1016/j.vaccine.2022.02.002 PMC 바로가기 [Article Type] Observational Study
Biological Matrix Supply Chain Shortages: More Matrices Are Now Rare-the Case for Surrogate MatricesEditorial Published on 2022-03-142022-10-04 Journal: The AAPS Journal [Category] 신약개발, [키워드] addition alleviate Biological Biomarker Biomarkers Cell chain contract research organization COVID-19 COVID-19 pandemic driven by ethical standards Gene therapy immunogenicity implication include instance maintain matrix outlined pandemic pharmacokinetic pharmacokinetics Regulatory Regulatory Authorities regulatory authorities. selected significant delay strained Strains Study protocol subject supply Support surrogate therapeutic unique Vaccine development [DOI] 10.1208/s12248-022-00694-1 PMC 바로가기 [Article Type] Editorial
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infectionsReview Published on 2022-03-082022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, [키워드] acute viral infection animal animal challenge studies anticipated Antiviral antiviral activity approval approved Biological breadth caused CFR Chemical clinical clinical benefit clinical development clinical evaluation clinical study conducted coronavirus 2 COVID-19 development disease drug drugs targeting Ebola Ebola virus Ebola virus disease Efficacy effort enzyme Evidence examined example facilitated FDA feasible Fever filoviruses food GS-5734 Hemorrhagic high-consequence pathogen highlight Hospitalization humans include Infection infectious agents inhibitor Laboratory testing Level 4 mechanism medical countermeasure NHP NHPs numbers of patient office outbreak outcome pandemic pathogen pathway Patient performed Prevent Program randomized clinical trials randomized, controlled trial RCTs Regulatory regulatory pathway Remdesivir Research respiratory RNA virus RNA-dependent RNA polymerase robust rule Safe SARS-CoV-2 severe disease Support therapeutic therapy treat Treatment Trial Vaccine viral infection viral pathogen viral replication virus virus infection while [DOI] 10.1371/journal.pntd.0010220 PMC 바로가기 [Article Type] Review
Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomesReview Published on 2022-03-042022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Algorithm Antibody Response Biological Care cellular clinical decision Clinical outcome clinical outcomes contribute coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity death develop disease dysregulated environmental factors Evidence explain expression facilitate faster fatality female females Gender Genetic Health help immune response immunologic response Inflammatory response male males mechanism Mild Mortality mounted outcome outcomes preventative measures Respiratory failure risk factor risk of infection robust SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe pneumonia severity Sex Therapies Treatment treatment strategy understanding with COVID-19 X inactivation [DOI] 10.1186/s13293-022-00417-3 PMC 바로가기 [Article Type] Review
Biological evaluation of a mechanical ventilator that operates by controlling an automated manual resuscitator. A descriptive study in swineResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] addition alteration anaesthesia Analysis automated Biological blood biochemistry Brain carbonate Clinical studies condition detect eight electrocardiogram evaluate Evidence health system healthy histopathological in vivo kidney Lactate liver lung mechanical ventilation mechanical ventilator organ outbreak Oxygenation PaO parameter pathological finding performed physiological level physiological response preclinical data produced reported Support tissue tissue damage ventilatory parameters Volume [DOI] 10.1371/journal.pone.0264774 PMC 바로가기 [Article Type] Research Article
Association of frailty and cognitive function disorders in old patients with COVID-19: a protocol of systematic review and meta-analysisCOVID-19 환자의 연약 및인지 기능 장애의 연관성 : 체계적인 검토 및 메타 분석의 프로토콜Article Published on 2022-03-032022-08-31 Journal: BMJ Open [Category] MERS, meta-analysis, SARS, [키워드] 95% CI 95% CIs age approach article Biological calculate China Chinese cognitive cognitive disorders Cognitive function Controlled COVID-19 COVID-19 infection COVID-19 infections delirium delirium & disorder Ethical approval Ethics frailty geriatric medicine heterogeneity hospitalised COVID-19 patient hospitalised COVID-19 patients increased risk Infrastructure Mental mental health Meta-analysis nervous system old age old age psychiatry. Patient patients with COVID-19 peer-reviewed Primary outcome Prospective PROSPERO protocol psychiatry public health random-effects model Registered registration number respiratory Respiratory disease selected systematic review systematic reviews [DOI] 10.1136/bmjopen-2021-056190 PMC 바로가기 [Article Type] Article
WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific communityPersonal View Published on 2022-03-012022-10-31 Journal: The Lancet. Microbe [Category] COVID-19, MERS, SARS, [키워드] anti-SARS-CoV-2 Biological calibrated calibration Committee conducted contribute COVID-19 COVID-19 vaccines diagnostic expected expert facilitate immune response Immunoglobulin National neutralising antibody Panel provide public health reagents reference SARS-CoV-2 Scientific community Standard the antibody response the WHO therapeutic View WHO [DOI] 10.1016/S2666-5247(21)00266-4 PMC 바로가기 [Article Type] Personal View
Biological, Psychological, and Physical Performance Variations in Football Players during the COVID-19 Lockdown: A Prospective Cohort StudyArticle Published on 2022-02-262022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] affected Biological BMI caused change clinically Concentration cortisol COVID-19 COVID-19 lockdown evaluate evaluated Fat mass ferritin Football hematocrit hematological parameters hemoglobin initial Italian lockdown maintain measurement performance performed physical physical performance physiological state plasma power level Prospective prospective cohort study Psychological Psychological stress red blood cells returned Serie A significantly Testosterone Variation Volume [DOI] 10.3390/ijerph19052739 PMC 바로가기 [Article Type] Article