Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-196가지 일반적인 암에서 ACE2 및 TMPRSS2의 유전적 감수성과 COVID-19에 대한 가능한 영향Article Published on 2021-07-012022-09-11 Journal: Cancer research and treatment [Category] SARS, 변종, [키워드] ACE2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological function Biological functions Cancer Colon Colorectal cancer common control sample controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient death demonstrated expression expression level expression levels expressions Gene Expression hazard ratio Hepatocellular carcinoma Impact increased risk Infection information invasive Invasive carcinoma investigated liver lung adenocarcinoma lung cancer material Neoplasms overexpression pandemic pathway Patients with cancer Precaution Prognosis Prostate reduced risk Serine significantly higher Spread Stage stomach cancer survival tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumor tumors upregulation [DOI] 10.4143/crt.2020.950 PMC 바로가기 [Article Type] Article
Antiviral and immunological activity of zinc and possible role in COVID-19아연의 항 바이러스 및 면역 학적 활성 및 Covid-19에서의 가능한 역할Review Published on 2021-06-152022-09-10 Journal: The British Journal of Nutrition [Category] 치료제, [키워드] animals Antiviral antiviral activity Antiviral agents approach article Biological functions Case series clinical trials complex conducted coronavirus COVID-19 deficiency Direct Diseases English functional homoeostasis humans immune response immune system immunological immunomodulator IMPROVE Infectious diseases involved literature mechanism mineral deficiency patients with COVID-19 presenting Prevention and control Respiratory tract infections scarcity Science Topic Viral viral infections vulnerability Zinc [DOI] 10.1017/S0007114521002099 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine MitigationReview Published on 2021-06-102022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Biological biological function Biological functions component coronavirus drug drug target functional homology knowledge Like Mitigation N protein nucleocapsid nucleocapsid protein other coronaviruses Potential Protein role SARS-CoV-2 Spread Structure target the N protein the SARS-CoV-2 Vaccine vaccine candidate virus [DOI] 10.3390/v13061115 PMC 바로가기 [Article Type] Review
Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2Pharmacology Published on 2021-06-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acid activate acute respiratory syndrome Anti-inflammatory Anti-inflammatory effects Anti-viral Antiviral Bioinformatics analysis Biological functions causative pathogen cellular Characteristics complement conducted coronavirus Coronavirus disease 2019 COVID-19 Cytokine storms enrichment analysis Factor Factors finding glycyrrhizic acid GO analysis growth factor Host ICAM1 identify IFN IL-17 IL-6 immune system indicated inflammatory pathway inflammatory pathways inhibit Interaction interactions mechanism miRNA MMP9 Mutation network analysis network pharmacology novel pathway Pathways predominant public health crisis reactive oxygen specy receptor signaling regulate SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly SOCS3 target targeted therapy targeting targets the cytokine storm therapeutic agent Therapies TLR2 TNF-α triggered Viral protein virus [DOI] 10.3389/fphar.2021.631206 PMC 바로가기 [Article Type] Pharmacology
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study패혈증에 대한 비타민 C 활성의 치료 표적 및 신호 메커니즘: 생물정보학 연구Article Published on 2021-05-202022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] accumulating addition assays benefit bioinformatics Bioinformatics analysis Biological functions biological processe Clinical practice conducted coronavirus coronavirus disease coronavirus disease-2019 Effect EGFR epidermal epidermal growth factor evidence of functional growth factor hub genes immune immune dysfunction implicated Inflammation involved JUN Kyoto life-threatening MAPK1 mechanism mitogen mitogen-activated protein kinase molecular mechanism molecular mechanisms network pharmacology Pathways Pneumonia Predictive Protein receptor Sepsis shown Signal transducer and activator of transcription Signaling signaling pathway signaling pathways STAT3 suppression target targets treat Treatment Vitamin C [DOI] 10.1093/bib/bbaa079 PMC 바로가기 [Article Type] Article
Chemistry and biology of ferritin페리틴의 화학 및 생물학Review Published on 2021-05-122022-09-11 Journal: Metallomics : integrated biometal science [Category] SARS, 바이오마커, [키워드] Biological functions Biology Biomarker Cancer Cell cell metabolism cellular cellular compartment Chemical biology Chemistry coronavirus disease Coronavirus disease 2019 described disease Diseases essential element ferritin Ferroptosis function functions impairment implicated iron iron homeostasis metabolism Protein reactivity required Research secreted variety [DOI] 10.1093/mtomcs/mfab021 PMC 바로가기 [Article Type] Review
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cellsTMBIM6, SARS-CoV-2 감염 숙주 세포에서 통합 멀티오믹스 데이터 분석으로 식별된 잠재적 바이러스 표적 단백질Research Paper Published on 2021-04-152022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Apoptosis bioinformatics biological function Biological functions caused Cell coexpression network collected coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 Data analysis differential expression Differential expression analysis Endoplasmic reticulum enrichment analysis expression function gene set enrichment analysis GSEA Host host cell host cells Inference interfere lipid metabolism mechanism metabolism multiomics data network Open Access Pathogenesis pathogenesis of SARS-CoV-2 pathway physiological respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Stress target protein the cells Therapeutic approach TMBIM6 trees Viral Viral protein Viral proteins virus weighted gene coexpression network analysis WGCNA [DOI] 10.18632/aging.202718 PMC 바로가기 [Article Type] Research Paper