Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria파지 감염 및 준치사 항생제 노출은 Enterococcus faecalis type VII 분비 시스템 의존적 방관자 억제 억제를 매개합니다.Research Article Published on 2021-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate activated addition Affect antagonism antibacterial activity antibiotic Antibiotics Bacteria Bacterial bacterial cell bacterial cells Bacterial infections bacterial pathogen bacteriophage bacteriophages bacterium bystander Cell cells clinically Concentration Consensus consequence Contact Deletion Disruption DNA damage DNA damaging dose Enterococcus Evidence evidence of expression facilitate Gene Expression gram growth highlight Host Immunity independent independent of induce Infection Interaction intrinsic killing membrane microbial Microbial communities multi-drug resistant multidrug resistant pathogen phage phages positive predicted respond restrict resulting secretion Serine Staphylococcus aureus Stress stress response Stressor susceptible therapeutic therapy These data threonine Transcription transcription factor Treatment Trigger triggering triggers upstream [DOI] 10.1371/journal.pgen.1009204 PMC 바로가기 [Article Type] Research Article
Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns조직병리학적 패턴에 특히 중점을 둔 COVID-19 관련 피부 발현의 임상병리학적 상관관계Review Published on 2021-01-012022-09-11 Journal: Clinics in dermatology [Category] SARS, 치료기술, 치료제, [키워드] abundance affected association bystander clinically condition correlation COVID-19 COVID-19 pandemic current cutaneous manifestation Cutaneous manifestations Cytokines Cytokines storm eccrine glands effective Endothelial cell endothelial cells epidermis epithelial epithelial cell epithelial cells immunohistochemistry lesions manifestation multiorgan injury nasopharyngeal nosology Novel coronavirus novel coronavirus SARS-CoV-2 occur organ Patient Perspective polymerase chain real-time polymerase chain reaction reported RNA SARS-CoV-2 SARS-CoV-2 strain skin skin biopsies skin lesions skin manifestations target organs virus with COVID-19 [DOI] 10.1016/j.clindermatol.2020.12.004 PMC 바로가기 [Article Type] Review
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets붉은털원숭이, 개코원숭이 및 마모셋 폐의 SARS-CoV-2 급성 감염에 대한 반응Article Published on 2021-01-012022-09-12 Journal: Nature Microbiology [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome adaptive age antibody Baboon Bronchoalveolar lavage bystander Cellular immune response Clinical sign clinical trials Computed tomography coronavirus coronavirus disease COVID-19 cytokine production cytokine response distress group humans Immune cell immunohistochemical analyses Infection interferon response lung Lung inflammation Lungs macaque macaques memory Mild moderate Non-human Pathologies progression response rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG T-cell Therapies titre Vaccine viral infection Viral RNA shedding was increased [DOI] 10.1038/s41564-020-00841-4 PMC 바로가기 [Article Type] Article
Deposition distribution of the new coronavirus (SARS-CoV-2) in the human airways upon exposure to cough-generated droplets and aerosol particlesArticle Published on 2020-12-312022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome addition airway airways angiotensin-converting enzyme 2 applied binding bystander Cell cellular entry Clinical deterioration coronavirus cough coughs COVID-19 deposition direct infection disease distribution droplet effort expressed Fluid dynamics form human airway infect infected patient infected with SARS-CoV-2 Infection initial symptom less majority Mild Model nasal New coronavirus non-specific oral mucosa pandemic parameter Particle Particles pathogen Pathogenesis Pneumonia Probability produced progression quarantine receptor reducing Respiration respiratory droplet SARS-CoV-2 SARS-COV-2 infection significantly sneezes Spread stochastic Symptom target target cells the disease thought tissue Transport Treatment upper airway upper airways upper respiratory tract viral infection Viral load virus while [DOI] 10.1038/s41598-020-79985-6 PMC 바로가기 [Article Type] Article
Assessment of changes in cardiopulmonary resuscitation practices and outcomes on 1005 victims of out-of-hospital cardiac arrest during the COVID-19 outbreak: registry-based studyOriginal Research Published on 2020-12-182022-10-29 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] COVID-19, MERS, SARS, [키워드] analysed arrest assessment bystander cardiac Cardiopulmonary Cardiopulmonary resuscitation changes in Characteristics circulation COVID-19 COVID-19 outbreak CPR D30 decrease drastic evaluated first aid French initiated involved less management Non-COVID-19 Out-of-hospital cardiac arrest outcome Patient reductions in registry Result Resuscitation return SARS-COV-2 infection survival survival rate [DOI] 10.1186/s13049-020-00813-x PMC 바로가기 [Article Type] Original Research
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia방관자 T 세포 활성화 및 반복되는 항생제 내성 세균성 폐렴의 증거와 관련된 급성 후 COVID-19Short Report Published on 2020-12-172022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] activated Analysis antimicrobial resistance Bacterial bystander caused changes contributed COVID-19 COVID-19 patient Evidence Genotype Human immunological metagenomics P. aeruginosa Pneumonia Pseudomonas aeruginosa radiological response to treatment SARS-CoV-2 Symptom T-cell activation t-cells activation Treatment Ventilator-associated pneumonia [DOI] 10.7554/eLife.63430 PMC 바로가기 [Article Type] Short Report
Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune SignaturesCOVID-19 환자의 B 세포 수용체 레퍼토리의 심층 시퀀싱으로 강력한 수렴 면역 신호가 나타남Immunology Published on 2020-12-152022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] antibody association B cell B-cell repertoire BCR bystander China clonal expansion Cohort convergence COVID-19 COVID-19 patient COVID-19 patients data set deep demonstrated Effects healthy control heavy chain help homologous identify immune response individual memory Neutralizing antibodies Patient patients prophylactic antibody receptor repertoire resource responses reveal SARS-CoV-2 SARS-CoV-2 spike protein Seasonal influenza sequence Sequencing signature Strong subset the disease therapeutic USA vaccination [DOI] 10.3389/fimmu.2020.605170 PMC 바로가기 [Article Type] Immunology
Treatment of out-of-hospital cardiac arrest in the COVID-19 era: A 100 days experience from the Lombardy regionResearch Article Published on 2020-10-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] absence administration ALS Analysis arrest automated bystander cardiac Cardiopulmonary circulation COVID-19 COVID-19 epidemic COVID-19 outbreak COVID-19 pandemic CPR demonstrated General population Hospital admission incidence increase in independent predictor Infection initiated Italy Lombardia lombardy Mantua occurred Patient Pavia performed presenting registry Result Resuscitation the epidemic Treatment univariable analysis [DOI] 10.1371/journal.pone.0241028 PMC 바로가기 [Article Type] Research Article
Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery DiseaseArticle Published on 2020-10-122022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Artery bystander cardiac troponin cardiovascular comorbidity CCS chronic coronary syndromes Clinical outcome Cohort Concomitant Coronary Coronary artery disease coronary syndrome Coronavirus disease 2019 COVID-19 COVID-19 patient disease severity enrolled enrolment high mortality rate Hospitalization Importance in-hospital mortality Injury mortality rate myocardial injury occurred outcomes Patient patients predictor screened Secondary outcomes significantly troponin two group value [DOI] 10.3390/jcm9103263 PMC 바로가기 [Article Type] Article
A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D DeficiencyPublic Health Published on 2020-09-102022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] “cytokine storm” analyses of variance basic biological plausibility bystander cardiovascular disease complication of COVID-19 COVID-19 COVID-19 illness COVID-19 mortality COVID-19 pandemic decrease deficiency Dengue fever diabetes effective ethnic group Evidence explain Factor fatality Fatality rate Google Google Scholar group Health Health disparities high-risk population highest hypertension Hypothesis immune system incidence include increase Increased individual innate immune system literature review men minority health obese outcomes Population predicted Preventive medicine prophylactically Randomized controlled trial reducing reflect reported Research researcher responsible review risk risk factor Safe serum vitamin D severe COVID-19 severity severity of COVID-19 significantly more spread of COVID-19 Support supported susceptible System USA viral infection virus replication Vitamin D vitamin D deficiency vitamin D supplement was performed [DOI] 10.3389/fpubh.2020.00513 PMC 바로가기 [Article Type] Public Health