Cancer cells – Page 4 – Communicable Diseases Research

Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment

정량적 단백질체학은 COVID-19 치료에 도움이 되는 이버멕틴의 광범위한 항바이러스 특성을 나타냅니다

Article

Published on 2021-04-012022-09-11
Journal: Journal of cellular physiology [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

TMPRSS2 발현에 대한 독특한 메커니즘은 엔잘루타미드에 의한 SARS-CoV-2 감염의 기관 특이적 억제를 설명합니다

Article

Published on 2021-02-082022-09-10
Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiandrogen antiviral action antiviral activity antiviral efficacy approved binding binding pattern Cancer cells caused Cell cells clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drugs Effect Efficacy enzalutamide epithelial cells evaluated Evidence explain expression Gene regulation global public health hACE2 human lung human lung cell human lung cells human lung organoid human lung organoids in vivo inhibited knockout mice lack locus lung cancer lung cell lung cells mechanism mediator mice organ-specific organoids pandemic Prostate Prostate cancer protective role reduce reducing Regulatory Repurposed drug respiratory SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus significantly Support therapeutic efficacy TMPRSS TMPRSS2 TMPRSS2 expression Tmprss2 knockout transmembrane serine protease transmembrane serine protease 2 treating COVID-19
[DOI] 10.1038/s41467-021-21171-x PMC 바로가기 [Article Type] Article

Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors

SARS-CoV-2 감염에 대한 숙주 전사 반응의 메타 분석은 인간 종양에서의 발현을 나타냅니다

Meta-Analysis

Published on 2021-01-282022-09-01
Journal: Scientific Reports [Category] 유전자 메커니즘, 진단,

[키워드] A549 activated adenocarcinoma bronchial epithelial cell Calu Calu-3 Cancer cancer cell Cancer cells Cell cell line cell line data common Data integration defined eight epithelial cells Gene regulatory networks histopathological Host immune response host response host responses Host transcriptional response IL-6 immune Immune cell infiltration immune response immune responses implicated Infection Inflammation interferon signaling lung adenocarcinoma lung cancer manifested model system Molecular biology NF-κB NHBE pathway Pathways Patient reveal SARS-CoV-2 SARS-COV-2 infection similarity subset the cell the SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional transcriptomic Tumor Tumour immunology type II interferon Viral viral infection viral infections virus viruses
[DOI] 10.1038/s41598-021-82221-4 PMC 바로가기 [Article Type] Meta-Analysis

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

인간 게놈 다양성 데이터는 L564P가 우세한 TPC2 변이체이며 M484L 기능 획득 효과와 관련된 금발 머리의 전제 조건임을 보여줍니다

Research Article

Published on 2021-01-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence addition affected Analysis analyzed association Bacterial infections bacterial toxin bacterial toxins Cancer cancer cell Cancer cells cation channel changes in characterized cholera toxin cholesterol data set database Degradation described diabete diabetes disease Diseases distribution drug target Ebola Ebola virus Effect example functional gain-of-function Genome Genome-wide association studies Genome-wide association study geographical distribution glucagon hair color Human human disease Human genome human population human populations implicated Infectious disease Infectious diseases investigated isoform likelihood melanin Meta-analysis metabolic disease mice nucleotide obesity overlapping Parkinson’s disease pathophysiological pharmacological physiological pigmentation defect pigmentation defects polymorphism Polymorphisms populations predominant Protein provide reduced resulting secretion Single nucleotide polymorphism single nucleotide polymorphisms systematic analysis traits Treatment variant Variation variations virus viruses was performed were assessed
[DOI] 10.1371/journal.pgen.1009236 PMC 바로가기 [Article Type] Research Article

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

DNA 복구-복제 인터페이스 및 SARS CoV-2를 표적으로 하는 핵산 효소에 대한 구조 기반 억제제에 대한 효율적인 화학적 스크리닝 방법

Article

Published on 2021-01-012022-09-11
Journal: Molecules [Category] Coronavirus, 유전자 메커니즘,

[키워드] Absorption ADME ADP-ribose affinity approach approved Cancer cancer cell Cancer cells Cassandra CASSIE Cell Chemical Chemical library Chemistry classical Compound defined distribution DNA DNA replication DNA replication and repair docking drug drug design Drug discovery effective effort enzyme excretion facilitate human protein human proteins increasingly inhibitor inhibitors iterative Mac1 macrodomain mechanism metabolism molecular nonstructural protein 3 Nsp3 nucleic acid optimization PARG Pathogenesis pathway predicted problem profiles protein 3 Proteins provide repair ribose RNA SARS CoV SARS CoV-2 SARS-CoV2 Screen screening method specific inhibitor specific inhibitors Structure structures target to define
[DOI] 10.1016/bs.mie.2021.09.003 PMC 바로가기 [Article Type] Article

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

SARS-CoV-2 감염 시 인간의 기도 및 폐포 오르가노이드에서 숙주 대사 조절 장애 및 세포 친화성 식별

Research Article

Published on 2020-12-122022-09-10
Journal: Protein & Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway alveolar animals AT2 Cancer cells caused Cell cell line cell lines cell tropism cells cellular metabolism ciliated club Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture distal downregulation Drug discovery dysregulation embryonic embryonic stem cells human airway human lung organoid human lung organoids humans immune response in vitro infect infected cell infected cells Infection inhibited lipid metabolism lung organoids Lungs mechanism metabolic processes metabolism neutralizing antibody Organoid organoids organs pandemic pathophysiological physiological condition physiological conditions proximal Remdesivir replicated respiratory respiratory droplet Respiratory droplets RNA-Seq route SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Spread stem cell supplementary material therapeutic drug upregulation virus infection
[DOI] 10.1007/s13238-020-00811-w PMC 바로가기 [Article Type] Research Article

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

Research Article

Published on 2020-11-232022-10-31
Journal: eLife [Category] Coronavirus, SARS,

[키워드] activated Affect allergy Allostery antibodies approved Asthma B cell B-cell B-cells bind binding Blood bruton tyrosine kinase BTK BTK inhibitor BTK inhibitors Cancer Cancer cells cancers catalytic activity change Chemotherapy conformational consequence COVID-19 Diseases disorder disrupt disrupting domain domains drug drug resistance drugs Effect effective enzyme examined FIVE full-length full-length protein Future help hydrogen/deuterium exchange mass spectrometry Ibrutinib inactive increase inhibitor inhibitors Interaction Joseph Kinase inhibitor leukemia lymphoma lymphomas maintain mechanism modify Mutation None not affect nuclear magnetic resonance other compound other disease phosphate Previous effort Protein Proteins Region regions Regulatory regulatory domain regulatory region Research responsible shifting treat treated treating COVID-19 Treatment treatment strategy tyrosine understanding while White blood cell
[DOI] 10.7554/eLife.60470 PMC 바로가기 [Article Type] Research Article

Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

Review

Published on 2020-11-022022-10-28
Journal: Biomolecules [Category] COVID-19, SARS,

Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities

Article

Published on 2020-10-082022-10-30
Journal: Molecules [Category] Coronavirus, MERS,

The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity

Review

Published on 2020-10-012022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] amoeba anti-apoptotic association bind binding biogenesis Cancer cells chaperone Contact cytosolic docking E3 ubiquitin ligase Endoplasmic reticulum fungi Genome implicated Innate Innate immunity involved IP3R3 kDa Lam6 Ltc1 Macrophage mammalian cells MAVS membrane contact sites Mitochondria mitochondrial mitochondrial antiviral-signaling protein mitochondrial carrier family mitochondrial protein import motifs outer membrane Parkinson’s disease Pathogens PINK1 promote Protein receptor recruitment resolved SARS-CoV-2 Site SLC25 TOM70 TPR Traffic transfer type I interferons viral infections yeast
[DOI] 10.3390/ijms21197262 PMC 바로가기 [Article Type] Review