Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies단순하고 민감한 특정 자체 샘플링 분석은 혈청-홍보 및 산후 연구에서 SARS-COV-2 항체 신호를 보호합니다.Article Published on 2022-02-032022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] 95% CI 95%CI Acute inflammation Analysis antibody Blood capture collected comparable correlation damaged DBS eluate DBS eluates diagnostic diagnostic sensitivity displaying ELISA ELISAs facilitate feasibility IgG and IgM IgM antibody individual Laboratory limits Limits of detection population level Post-vaccine post-vaccine response Prevalence provide recipient remained RNA vaccines robust SARS-CoV-2 SARS-CoV-2 antibody secure sensitivity sera serological serum simple specificity specimen specimen collection Vaccine viral infection WHO [DOI] 10.1038/s41598-022-05640-x PMC 바로가기 [Article Type] Article
Semantic segmentation of COVID-19 lesions with a multiscale dilated convolutional network멀티 스케일 확장 된 컨볼 루션 네트워크를 사용한 Covid-19 병변의 시맨틱 세분화Article Published on 2022-02-032022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, [키워드] aggregate Automatic automatic detection average best capture clinical analysis Computed tomography Computer science COVID-19 COVID-19 patient dataset Diagnosis Dice facilitate feature Features Follow-up Image processing information lesion lesions machine learning medium reduce Research Segmentation sensitivity similarity tissue tissues union [DOI] 10.1038/s41598-022-05527-x PMC 바로가기 [Article Type] Article
Rapid detection of novel coronavirus SARS-CoV-2 by RT-LAMP coupled solid-state nanoporesRT-LAMP 결합 고체 나노 기공에 의한 신종 코로나바이러스 SARS-CoV-2의 신속한 검출Article Published on 2022-02-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adopted Amplicon amplification capture caused clinical copy number Coronavirus-2 COVID-19 disease spread Early detection event rate Genes gold gold standard intrinsic Nanopore Nasopharyngeal swab novel coronavirus SARS-CoV-2 nucleocapsid pandemic of COVID-19 platform point-of-care positive public health raised Rapid respiratory RT-LAMP RT-PCR assay Saliva saliva samples SARS-CoV-2 SARS-CoV-2 detection sensitivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Solid-state nanopore. Spread the disease threshold [DOI] 10.1016/j.bios.2021.113759 PMC 바로가기 [Article Type] Article
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic발현이 강화된 SARS-CoV-2 바이러스 스파이크 모방체의 당화 및 혈청학적 반응성Research Article Published on 2022-01-302022-09-10 Journal: Journal of Molecular Biology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Abstract analysed Analysis antibody antigenic capture changes in clinical sample clinical samples COVID-19 patient COVID-19 patients detect discrepancies exhibit expression Extensive feature globe glycoprotein Glycoproteins glycosylation HexaPro IgA IgG IgM response IgM responses impacted include infected individual infected individuals Mimetic N-linked glycan N-linked glycans N-linked glycosylation observation performed Perturbation prefusion conformation proline proline substitution Protein protein structure reactivity S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike sera serological serological activity serological assessment serological studies serology spike stability Substitution substitutions trimeric spike Variation variations Viral viral glycoprotein viral glycoproteins virus viruses [DOI] 10.1016/j.jmb.2021.167332 PMC 바로가기 [Article Type] Research Article
Deep learning via LSTM models for COVID-19 infection forecasting in India인도에서 Covid-19 감염 예측을위한 LSTM 모델을 통한 딥 러닝Research Article Published on 2022-01-282022-09-10 Journal: PLoS ONE [Category] 변종, [키워드] Accuracy bidirectional capture complexity country COVID-19 infection COVID-19 pandemic Culture Data collection deep Economy Factor Health India Infection infections lack likelihood logistics mathematical Mathematical models memory population density predict Prominent regions reliability Reporting short term short term memory situation spatiotemporal Spread variant virus with COVID-19 [DOI] 10.1371/journal.pone.0262708 PMC 바로가기 [Article Type] Research Article
ASPICov: An automated pipeline for identification of SARS-Cov2 nucleotidic variantsASPICOV : SARS-COV2 뉴클레오티드 변이체 식별을위한 자동화 된 파이프 라인Research Article Published on 2022-01-262022-09-10 Journal: PLoS ONE [Category] SARS, 변종, [키워드] Analysis automated biologist capture Complete Data analysis Illumina Ion NGS variant [DOI] 10.1371/journal.pone.0262953 PMC 바로가기 [Article Type] Research Article
A Decade of Post-Intensive Care Syndrome: A Bibliometric Network Analysis10년의 중환자실 증후군: 서지 네트워크 분석Article Published on 2022-01-232022-09-10 Journal: Medicina [Category] SARS, 변종, [키워드] Analysis analyzed Annual article articles authors bibliometric analysis capture Care citation co-occurrence cognitive country COVID-19 Critical Critical illness database effort England English followed by functional Germany growth highlight impairment increase in index intensive care unit introduced knowledge material mental health MOST Netherlands network network analysis physical PICS post-intensive care syndrome Research research collaboration research output searched survivor survivorship syndrome Treatment variant Web Web of Science [DOI] 10.3390/medicina58020170 PMC 바로가기 [Article Type] Article
Stressors faced by healthcare professionals and coping strategies during the early stage of the COVID-19 pandemic in Germany독일의 Covid-19 Pandemic의 초기 단계에서 의료 전문가와 대처 전략이 직면 한 스트레스 요인Observational Study Published on 2022-01-182022-09-10 Journal: PLoS ONE [Category] SARS, 임상, 치료기술, [키워드] Asia average benefit buffer calmness capture Care coded concerning conducted Contact coping strategies Coping strategy country COVID-19 pandemic cross-sectional demonstrated detect early stage EFA Effect effective effective coping Effects Emergency Care examined exchange facilitate Factor Factor analysis Families fatigue friends Future Germany health systems healthcare Healthcare professional healthcare professionals Healthcare system Healthcare systems healthcare worker Healthcare workers hospital identify Interference International knowledge longitudinal design male Masks measure Measures medical staff moderate mood National pandemic Pandemics Patient Perceived stress prehospital emergency care professional Psychological psychological Impact Psychological stress question reduced Regulation reported resource response responses Result schedule SEM significantly significantly higher social distancing Social support Stress stress level Stressor stressors Support team utilization with COVID-19 workload Workplace [DOI] 10.1371/journal.pone.0261502 PMC 바로가기 [Article Type] Observational Study
Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopesEpistatic 모델은 SARS-CoV-2 단백질 및 에피토프에서 돌연변이 부위를 예측합니다530 Published on 2022-01-122022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anticipation appearance approach assist build capture characteristic complex concerning coronavirus COVID data-driven models database databases direct coupling analysis domain Efficacy Efficiency epistasis epitope exploration identify immune response immunological increasingly measure MOST mutability mutable mutagenesis data Mutation mutations observations observé other coronaviruses outbreak pandemic pathogenicity predict predicted prediction predictor profile protein stability receiver operating characteristic Receptor binding domain reduce respiratory resulting SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus Significance Spike protein Spread statistical model tested the spike protein therapeutic interventions Transmissibility Vaccine Variability variant variants variants of concern Viral Viral diseases viral evolution viral outbreak virus [DOI] 10.1073/pnas.2113118119 PMC 바로가기 [Article Type] 530