CD71 + Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal MiceImmunology Published on 2020-11-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] abrogated activated Against age apocynin appear Asymptomatic Bacteria Blood Bone marrow Brain CD14 CD45 CD71+ erythroid cells compromise control group COVID-19 COVID-19 infection cytokine production Diseases erythroid explain expressing Frequency highlight Human Immune cell immune system Immunosuppression immunosuppressive in vitro Infant Infants Infection Listeria monocytogene liver mechanism mice Mild monocyte Neonatal neonatal infections Neonate Newborn Newborns Older Peripheral blood physiological potential mechanism precursor property proportion reactive oxygen specy reduction in regulated response ROS ROS production significantly higher spleen suppressed survival rate susceptibility susceptible systemic T cells these cell [DOI] 10.3389/fimmu.2020.597433 PMC 바로가기 [Article Type] Immunology
Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations인간 말초 혈액 백혈구 개체군에 대한 COVID-19의 면역학적 각인Original Article Published on 2020-11-222022-09-01 Journal: Allergy [Category] SARS, 진단, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition antibody antibody levels B cells CD25 CD3 CD31 CD38 CD4 CD45 CD45RA CD8 Cell cells cellular Cellular immune response cellular immune responses central memory clinical immunology Cohort convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients determined by disease domain effector memory elevated ELISA expression flow cytometry FOXP3 healthy control HLA‐DR immune responses immune system immunological immunological change immunological changes immunosorbent Infection infections innate immune system investigated leukocyte population Lymphocytes Mild Mild disease multiparametric flow cytometry neutrophil Neutrophils nucleocapsid pandemic parameters Patient patients Peripheral blood qPCR Quantitative quantitative PCR RBD receptor receptor‐binding domain Recombination reduction reflected regression analysis respiratory responses Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‑CoV2 SARS‐CoV‐2 sense sense of taste severe acute respiratory syndrome Coronavirus significantly Spike protein subject T cell T cells T regulatory cell T regulatory cells T‐cell Taste thymic emigrant thymic emigrants transitional B cell transitional B cells triggered Viral [DOI] 10.1111/all.14647 PMC 바로가기 [Article Type] Original Article
CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patientsResearch Paper Published on 2020-10-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] accompanied Affect age CD3 CD45 CD8 Clinical characteristics Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 vaccines Critical CRP cut-off cut-off value deficiency diagnostic dysfunction early diagnosis early infection Effectiveness Factor IL-1β IL-6 level IL-8 Immune cell Immune system dysfunction immunopathology lymphocyte memory T Mortality naïve Non-severe case non-severe cases non-severe patient non-severe patients outbreak Patient Pneumonia predict public health emergency SARS-COV-2 infection sensitivity Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe pneumonia World Health Organization [DOI] 10.18632/aging.103941 PMC 바로가기 [Article Type] Research Paper
Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine CoronavirusPathogenesis and Immunity Published on 2020-09-302022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Adaptive immune response addition Analysis Antiviral approach Brain C57BL/6 CD45 Cell cellular pathway Central nervous system Central nervous system infections CNS contributing to coronavirus Critical Defense defined Demyelination disease Diversity effective evaluate expressed expressing heterogeneity Host host defense identify Immune cell immune response Immune-mediated immunological immunological mechanism immunology infecting Infection Intracranial involved landscape macrophages mice microglia molecular molecular network mouse hepatitis virus mRNA expression profile murine nervous nervous system Neuroimmunology neurologic neurotropic pathway RNA scRNAseq Single-cell RNA sequencing Stage subset susceptible System the Coronaviridae understanding unique viral infection viral persistence viral replication virus [DOI] 10.1128/JVI.01295-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity
A descriptive study of random forest algorithm for predicting COVID-19 patients outcomeEmergency and Critical Care Published on 2020-09-092022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 95% CI age Algorithm Analysis analyzed applied AUC can be used CD45 CD8 Clinical characteristics clinical information Clinical outcome clinical risk collected coronavirus disease COVID-19 COVID-19 patient COVID-19 patients descriptive study diagnosed with COVID-19 diagnostic died discharged distribution Dyspnea early stage endpoints Factor global public health high accuracy hospital identify in-hospital mortality increase in Laboratory lactate dehydrogenase LDH Logistic Mortality NLR occurred outbreak outcome parameters Patient patient outcome patients patients hospitalized potential risk predict predictor predictors random Random Forest algorithm Result RFE risk ROC Curve selected Specific subset the disease Treatment univariable was used were excluded Wuhan Wuhan, China [DOI] 10.7717/peerj.9945 PMC 바로가기 [Article Type] Emergency and Critical Care
SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 − Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 InflammasomeArticle Published on 2020-07-202022-10-28 Journal: Stem cell reviews and reports [Category] COVID-19, MERS, [키워드] ACE2 ACE2 receptor activate Ang II CD133 CD34 CD45 Cell cell death cell lysis cells COVID19 Cytokine storm damaged described Effect endothelial entry receptor enzyme Express expressed functional Genes hematopoietic Hematopoietic stem cell hematopoietic stem cells human cells hyperactivate indicate induce infect Inflammasome Interaction murine NLRP3 inflammasome progenitor cell protease TMPRSS2 protective effect pyroptosis RAAS raise receptor response SARS-CoV-2 SARS-CoV2 shown spike Spike protein stem cell stem cells the SARS-CoV-2 these cell tissue transmembrane umbilical cord blood viral spike protein virus VSELs [DOI] 10.1007/s12015-020-10010-z PMC 바로가기 [Article Type] Article
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant HepatitisResearch Article Published on 2015-09-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type [DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays고처리량 삼색 유세포 분석 기술을 이용한 생물학적 시험에서 말라리아 원충 플라스모디움 팔시파룸 감염 평가Methodology Published on 2014-10-202024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] ADCI bioassay CD45 Coriphosphine-O flow cytometry malaria Mitotracker red Plasmodium falciparum Tri-colour [DOI] 10.1186/1475-2875-13-412 PMC 바로가기 [Article Type] Methodology
MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem CellsResearch Article Published on 2009-11-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus [DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article