Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization항체 중화에 대한 SARS-CoV-2 람다 변이체의 내성 증가Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition affecting antibody Antibody neutralization binding class Combination contributed convalescent plasma country defined elicited evaluated immunization Inactivated vaccine Increased Lambda Lambda variant monoclonal antibody NAb natural infection neutralization neutralization test plasma polyclonal antibodies polyclonal antibody RBD of SARS-CoV-2 reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sensitivity significantly Spike protein spread to Structure Substitution suggested the RBD variant Viral viral mutation [DOI] 10.1016/j.jcv.2022.105162 PMC 바로가기 [Article Type] Article
Engineering defensin α-helix to produce high-affinity SARS-CoV-2 spike protein binding ligands고친화성 SARS-CoV-2 스파이크 단백질 결합 리간드를 생성하기 위한 디펜신 α-나선 공학Article Published on 2022-06-012022-09-11 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid amino acid residue amino acid residues angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacterial binding binding ligand blocked class competitive inhibition coronavirus COVID-19 Critical defensin demonstrated diagnostic diagnostics disrupt Disulfide Engineering exceptional expressed expression high-affinity binding homogeneity host cell host cells initial Interaction kDa Ligand ligands Protein protein-protein interaction purified receptor residue SARS-CoV-2 SARS-CoV-2 diagnostics SARS-CoV-2 neutralizing antibodies SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus soluble ACE2 Spike protein spike-protein the SARS-CoV-2 the spike protein therapy viral infection were used α-helix [DOI] 10.1002/pro.4355 PMC 바로가기 [Article Type] Article
Effectiveness of a Self-Management Program to Improve Cognition and Quality of Life in Epilepsy: A Pragmatic, Randomized, Multicenter TrialRandomized Controlled Trial Published on 2022-05-242022-10-05 Journal: Neurology [Category] 임상, [키워드] age Analysis baseline Care change class classification Cognition Cognitive impairment conducted Control controls COVID-19 pandemic demonstrated determine Effectiveness Efficacy England epilepsy Evidence feasibility female Future group Health IMPROVE improvement Intervention intervention group life Long-term follow-up measure Modification multisite New outcome Pairwise comparison participant Pragmatic Program provide Quality Quality of life recruited replicated Replication Research significantly training Treatment Trial were assessed [DOI] 10.1212/WNL.0000000000200346 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 in silico binding affinity to human leukocyte antigen (HLA) Class II molecules predicts vaccine effectiveness across variants of concern (VOC)인간 백혈구 항원(HLA) 클래스 II 분자에 대한 SARS-CoV-2 in silico 결합 친화도는 관심 변이체(VOC) 전반에 걸쳐 백신 효과를 예측합니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody production Antigen arising Beta binding affinity caused class clinical effectiveness concern Delta Effectiveness Gamma HLA Human human leukocyte antigen in silico Lancet leukocyte offer omicron overlap pool predict predicted Predictive SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein statistically significant Vaccine variant variants of concern VoC widespread Williams [DOI] 10.1038/s41598-022-11956-5 PMC 바로가기 [Article Type] Article
The global impact of COVID-19 on drug purchases: A cross-sectional time series analysisCOVID-19가 의약품 구매에 미치는 글로벌 영향: 횡단면 시계열 분석Article Published on 2022-05-012022-09-11 Journal: Journal of the American Pharmacists Association : [Category] 치료제, [키워드] Action adrenergic drug Analysis antiviral drugs average change changes in class conducted coronavirus disease Coronavirus disease 2019 correction country COVID-19 COVID-19 pandemic cross-sectional determine Disruption distribution drug events Evidence evidence of greater Health Organization increase in inhaler inhalers IQVIA medication Medicine Medicines moving average pandemic Pandemics ranged risk subsequent Supply chain tested United Nation United Nations were assessed World Health Organization [DOI] 10.1016/j.japh.2021.12.014 PMC 바로가기 [Article Type] Article
Psychological Health and Sleep Quality of Medical Graduates During the Second Wave of COVID-19 Pandemic in Post-epidemic Era포스트 전염병 시대의 COVID-19 팬데믹의 두 번째 물결 동안 의대 졸업생의 심리적 건강과 수면의 질Article Published on 2022-04-072022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted odds ratio affected Analysis anonymously Anxiety class collected consequence coping COVID-19 COVID-19 virus cross-sectional Depression Factor Guangzhou Guangzhou, China Health increased risk index information Local Logistic regression analyses medical graduates mental health mental health problem mental health problems multivariate logistic regression outbreak pandemic Panic participant performed Pittsburgh positive Prevalence problems protective factor Psychological Quality questionnaire SAS SDS second second wave Self-Rating Anxiety Scale Self-Rating Depression Scale Sleep sleep quality Spread student vaccination Vaccination Status variant Wave were assessed were measured [DOI] 10.3389/fpubh.2022.876298 PMC 바로가기 [Article Type] Article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape새로운 SARS-CoV-2 계통에서 돌연변이 에피토프의 실리코 분석은 전 세계적으로 향상된 CD8+ T 세포 반응성과 면역 반응 탈출의 징후를 시사합니다Article Published on 2022-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Analysis antibody B.1.1.7 B.1.351 binding Binding prediction Brazil CD8+ CD8+ T cell CD8+ T cell response CD8+ T cells change class Class I HLA conserved country Coverage COVID-19 E484K epitope Epitopes evade Evidence exhibiting expected fraction highlight HLA allele HLA alleles HLA binding immune response immunogenic in silico individual investigated Lineage lineages mutant Mutation N501Y new SARS-CoV-2 P.1 P.2 peptide peptides predicted provided reactivity reference sequence respond response SARS-CoV-2 SARS-CoV-2 variants silico predictions South Africa spike T cell T cell epitopes T cells TCR Transmissibility variant variants variants of concern Viral load [DOI] 10.1016/j.meegid.2022.105236 PMC 바로가기 [Article Type] Article
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patientsShort communication Published on 2022-04-012022-10-05 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied association class correlation COVID-19 COVID-19 hospitalization Critically ill genetic marker Genome GWAS Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients independent initiative instrumental variable mendelian randomization obesity objective Patient platform reported Research design Result risk risk factor shown T2D type 2 diabete type 2 diabetes was performed [DOI] 10.1016/j.metabol.2022.155156 [Article Type] Short communication
Efficient COVID-19 CT Scan Image Segmentation by Automatic Clustering Algorithm자동 클러스터링 알고리즘을 통한 효율적인 COVID-19 CT 스캔 이미지 분할Article Published on 2022-03-302022-09-11 Journal: Journal of Healthcare Engineering [Category] 변종, [키워드] Accuracy Algorithm automated Automatic carried chest CT scan class classification COVID-19 COVID-19 disease COVID-19 treatment criteria CT scan detect develop disease Efficiency efficient ENhance experiment False negative faster feature Features function help Image Image segmentation input introduced iteration iterations Local machine-learning measure Population size Precision random Random forest recall reported RT-PCR test Segmentation specificity SSA test result tested threshold value time-consuming Treatment Trial variant [DOI] 10.1155/2022/9009406 PMC 바로가기 [Article Type] Article