clinical disease – Page 4 – Communicable Diseases Research

Distinctive Biomarker Features in the Endotheliopathy of COVID-19 and Septic Syndromes

COVID-19 및 패혈성 증후군의 내피병증에서의 독특한 바이오마커 특징

Comparative Study

Published on 2022-01-012022-09-11
Journal: Shock (Augusta, Ga.) [Category] 바이오마커,

Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection

SARS-CoV-2 감염에 대한 자가항체 반응의 역설적인 성별 특정 패턴

Research

Published on 2021-12-302022-09-10
Journal: Journal of Translational Medicine [Category] SARS, 진단, 치료법,

[키워드] AABs absence Activation acute response age analyses antibody Antigen antigens assigned asymptomatic infection autoantibody autoantigen Autoantigen selectivity Autoimmune Autoimmune disease Autoimmune diseases autoreactivity blood draw breadth classic clinical disease Clustering Cohort collected COVID-19 COVID-19 illness demographic data effective intervention effective interventions Evidence evidence of exhibit extreme greater healthy control homology Immune-mediated inflammatory activity lead men men and women modulating molecular multivariable analyses nucleocapsid protein number of symptom participant presence or absence Prevalence reactivity reported symptom reported symptoms Result SARS-CoV-2 SARS-COV-2 infection serological severe COVID-19 illness Sex difference sex differences socio-demographic supplementary material susceptibility Symptom symptomatic infection Symptoms trajectory triggered within 6 months women
[DOI] 10.1186/s12967-021-03184-8 PMC 바로가기 [Article Type] Research

Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID

제2형 당뇨병, 후기 발병 알츠하이머병 및 장기 코로나에서 엽산 매개 단일 탄소 대사 장애

Review

Published on 2021-12-232022-09-10
Journal: Medicina [Category] SARS, 유전자 메커니즘,

[키워드] Abnormalities Alzheimer’s disease Alzheimer’s disease biochemical Biomarker biosynthetic biosynthetic pathways carbon clinical disease COVID COVID-19 cytoplasm developmental diabetes Diabetes Mellitus Diseases elevated epigenetics folate functional homocysteine hyperhomocysteinemia Impaired incorporation knowledge Long Long COVID mechanism metabolic network metabolic pathway metabolic pathways metabolism Mitochondria MTHFR gene mutations nucleus nutritional B vitamin deficiencies PASC pathology pathway progression Repurposed drugs responsible SARS-CoV-2 Stress the reader Therapeutics Treatment Type type 2 diabete Type 2 diabetes mellitus Vitamin vitamins
[DOI] 10.3390/medicina58010016 PMC 바로가기 [Article Type] Review

Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses

Minireview

Published on 2021-12-212022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome antiviral drugs approach approved category A-C pathogens caused clinical disease Clinical efficacy clinical testing clinical trial Combination Contact coronavirus coronavirus disease countermeasures COVID-19 develop drug drug combination drug resistance drug synergy early treatment Ebola virus effective Efficacy effort emerging virus endpoints ENhance highest in vitro indications infected individual lack likelihood limit LINE model-driven approach Novel coronavirus Other pandemic pandemic preparedness Pandemics Prophylaxis regimen SARS-CoV-2 synergistic therapeutic Toxicity treatments for COVID-19 Vaccine viral pandemic viral pathogen viral pathogens virus while
[DOI] 10.1128/mbio.03347-21 PMC 바로가기 [Article Type] Minireview

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

인간 COVID-19 회복기 혈장으로 조기에 치료된 붉은털 원숭이의 SARS-CoV-2 감염

Research Article

Published on 2021-11-242022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered administration animal models of infectious diseases benefit Blood blood clotting clinical disease Clinical studies clinical study collected contribute Control convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease early infection Efficacy Endpoint had no Human Human plasma immune pressure immunization Immunotherapy IMPROVE in vivo include Infection Inflammation information Interpretation lung macaque macaques mechanism medium microbial pathogenesis nasal Neutralizing antibodies neutralizing antibody nonhuman primate normal human plasma normalization not reduce pandemic Pandemics passive immunization plasma produced provided question receiving reduce respiratory SARS-CoV-2 SARS-COV-2 infection secretion sequence severe acute respiratory syndrome Coronavirus symptom onset tested therapeutic Treatment Vaccine variant Viral viral loads viral shedding viral variant Virology Virus neutralization
[DOI] 10.1128/Spectrum.01397-21 PMC 바로가기 [Article Type] Research Article

Targeting the Endothelium in the Treatment of COVID-19 Early Clinical Stages: Results of a Randomized Placebo-Controlled Trial

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 임상,

[키워드] 95% CI 95% confidence interval analyzed Antithrombotic assigned benefit bleeding C reactive protein C-reactive protein calculated calculator Care caused clinical clinical disease Clinical stage Cluster Comorbidity Complication concerning conducted COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer D-dimer level D-dimer value determine difference Disease progression dose Effect Endothelial cell Endpoint evaluate the effect evaluated Fewer patient First wave Follow-up healthcare high risk hospital Hospital admission Inclusion inclusion criteria induce Intervention Kaplan-Meier curve limitation lockdown major bleeding medication Mortality normally distributed oral anticoagulant oxygen support participant Patient patients required hospitalization per-protocol analysis percentage performed physician Placebo pleiotropic Primary outcome progression randomized placebo-controlled trial Randomly receive reduced required responsible Result risk SARS-CoV-2 Serum level serum levels Seven Side effects significantly higher Standard of care student suggested sulodexide supplemental oxygen supplemental oxygen support synergistic t-test T-tests target targeting the placebo group Thromboembolic events treat analysis Treatment Trial Vascular Vascular endothelium was used were assessed were blinded Wilcoxon test
[DOI] 10.1182/blood-2021-151814 [Article Type] Conference abstract

An outbreak of SARS-CoV-2 with high mortality in mink ( Neovison vison) on multiple Utah farms

여러 유타 농장에서 밍크(Neovison vison)의 사망률이 높은 SARS-CoV-2 발생

Research Article

Published on 2021-11-122022-09-12
Journal: PLoS Pathogens [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Animal host animal hosts animals anorexia bat bats breadth caused Chain Reaction clinical disease collected coronavirus damage death demonstrated disease distribution early phase edema effort epithelial F486L FIVE Gross high mortality hosts Human humans In situ hybridization indicate information interstitial pneumonia Localization localized infection lower respiratory system lung Lymph node measure mink moderate molecular Mortality multiple organ multiple organs Mutation nasal turbinates necropsy Neovison Novel coronavirus occurred outbreak pathology perivasculitis polymerase chain polymerase chain reaction Polymorphisms potential transmission PPE Prevent provided pulmonary congestion Pulmonary edema RBD mutation reported reservoir reservoirs Respiratory disease respiratory tract reveal reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 viral RNA sequenced severe acute respiratory syndrome Coronavirus severe respiratory disease Spread strain susceptible symptomatic the disease The United States tissue tissues tracheobronchial Transmission unique United States upper respiratory tract Utah Vasculitis viral infection Viral RNA Viral transmission virus virus transmission while whole genome Whole genome sequencing Y453F
[DOI] 10.1371/journal.ppat.1009952 PMC 바로가기 [Article Type] Research Article

A regulatory T cell signature distinguishes the immune landscape of COVID-19 patients from those with other respiratory infections

Research Article

Published on 2021-11-102022-11-01
Journal: Science Advances [Category] COVID-19,

[키워드] Activation acute respiratory syndrome changes in circulating clinical disease coronavirus correlated COVID-19 patient COVID-19 patients COVID-19 severity Critical defined description flu Frequency Hospitalized hospitalized patient identify immune immune response immune signature Immunity indicate infected with SARS-CoV-2 Influenza knowledge marker Migration other respiratory infection other respiratory infections overlapping Patient patients patients hospitalized Regulatory respiratory syncytial virus RSV RSV infection SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2–infected patient severe inflammation T cell T cell phenotype therapy Treatment strategies
[DOI] 10.1126/sciadv.abj0274 PMC 바로가기 [Article Type] Research Article

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

Research Article

Published on 2021-10-222022-10-28
Journal: Science Advances [Category] COVID-19,

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Article

Published on 2021-10-202022-10-30
Journal: NPJ Vaccines [Category] COVID-19,

[키워드] addition Animal host Antigen approach B.1.1.7 variant clinical disease close contact Critical detrimental develop effective Epidemiology expressing Human induce Infection infection with SARS-CoV-2 Infectious diseases Infectious virus mutations nasal swab Neutralizing antibody response neutralizing antibody responses Oropharyngeal pandemic Particle Prevent protective immunity raised reduce replicon reported required risk RNA vaccines Safe SARS-CoV-2 SARS-COV-2 infection spike Spread spread to susceptible the SARS-CoV-2 Transmission transmission of SARS-CoV-2 Vaccine vaccine candidate variety Venezuelan equine encephalitis virus
[DOI] 10.1038/s41541-021-00390-9 PMC 바로가기 [Article Type] Article