Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal EnteroidsImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Antigen presentation antigen-presentation cellular tropism chemokine Clinical signs coronavirus Coronaviruses dataset DEGs demonstrated diarrhea differentially expressed gene discrepancy elevated elicited enteric epidemic diarrhea epithelial exhibited expression gastroenteritis help histocompatibility complex Host IFN IFN response in vivo infect Infection interactions interferons intestinal epithelia intestine ISG majority mechanism MHC-I Neonatal NLR NLRC5 pathogenicity PDCoV PEDV Porcine deltacoronavirus presentation public health receptor replicated response responses TGEV transcriptional profile transcriptomics Treatment type I unique upregulation virus watery while [DOI] 10.3389/fimmu.2021.826882 PMC 바로가기 [Article Type] Immunology
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2 감염 중 면역 역학의 연령 관련 차이Research Article Published on 2022-01-172022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] advanced age age aging Analysis animal animals Antiviral Bronchoalveolar lavage fluid Cellular immune response cellular immune responses clinical observations Clinical signs cohorts cytokine cytokine level cytokine levels difference disease eight evaluated exhibited flow cytometry immune Immune homeostasis immune response immune responses immunohistochemistry impair Increased inflammation-associated gene inflammation-associated genes Inflammatory Innate immune defense innate immune defenses inoculated lipid mediator Local macaque mediator multiplex Older outcomes pro-inflammatory response pulmonary infiltrates responses return rhesus rhesus macaque rhesus macaques risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single-cell Single-cell transcriptomics sustained T-cell Response T-cell responses Thoracic transcriptomics various tissues Viral viral RNA quantification virus replication [DOI] 10.26508/lsa.202101314 PMC 바로가기 [Article Type] Research Article
Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19COVID-19의 발달에서 숙주의 면역 다형성 및 SARS-COV-2의 유전 적 가변성의 의미Review Published on 2022-01-062022-09-10 Journal: Viruses [Category] SARS, 변종, [키워드] ACE2 ACE2 overexpression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting agent angiotensin Angiotensin-converting enzyme binding Characteristics claimed Clinical signs coagulation disorders coronavirus coronavirus disease Coronavirus-2 country COVID-19 develop development dry cough Epigenetic explain Factor Fever Genetic genetic factors genetic susceptibility headache immune polymorphism immune system Immunopathogenesis include increment infection rate involved Loss of Smell loss of smell or taste molecules Most patients pandemic patients polymorphism respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe pneumonia Symptoms Taste Variability Viral viral entry viral infection [DOI] 10.3390/v14010094 PMC 바로가기 [Article Type] Review
Optimization of Single-Dose VSV-Based COVID-19 Vaccination in Hamsters햄스터에서 단일 용량 VSV 기반 COVID-19 백신 접종의 최적화Immunology Published on 2022-01-062022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] CD4 CD8 Clinical sign Clinical signs Combination COVID-19 COVID-19 pandemic Ebola virus Effect Efficacy glycoprotein greater hamster hamsters Health highlight Highlights IgG response immunogenicity intramuscularly lung Lungs NK cell optimization Pneumonia Protective raise rVSV-ZEBOV GP SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS2 severe acute respiratory syndrome coronavirus-2 Spike protein stability stomatitis T cell T cell response the SARS-CoV-2 vaccination Vaccine vaccine candidate Vaccines vesicular stomatitis vesicular stomatitis virus Viral viral variant Viral variants VSV-EBOV VSV-SARS2 [DOI] 10.3389/fimmu.2021.788235 PMC 바로가기 [Article Type] Immunology
Surveillance of SARS-CoV-2 antibodies of patients in the local affected area during Wuhan lockdownWuhan Lockdown 동안 국소 영향을받는 지역에서 환자의 SARS-COV-2 항체 감시Research Article Published on 2022-01-042022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] affected age All participants clinic Clinical sign Clinical signs Comorbidity convalescent patient Convalescent patients COVID-19 COVID-19 outbreak COVID-19 pandemic fragment of gold herd immunity highest Humoral immunity IgG IgM IgM and IgG Immunity indicated individual individuals information Local lockdown medical staff men natural reservoir no significant difference nucleic acid nucleocapsid outbreak Outpatient participant Patient positive rate positive rates Prevalence prevalence rate provide qualitative test Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM SARS-CoV-2 infections sensitivity Seroprevalence Serosurveillance significant difference significantly higher specificity Spike protein syndrome the mean the SARS-CoV-2 Vaccination strategy Vaccine virus was measured were measured women Wuhan [DOI] 10.1186/s12879-021-07010-w PMC 바로가기 [Article Type] Research Article
Cerebral thrombophlebitis revealing SARS-CoV-2 infection: About one caseCase Report Published on 2021-12-212022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] Anticoagulant treatment association cerebral Cerebral thrombophlebitis Clinical signs Complication demonstrated increased risk Inflammatory intensive care less mechanism pandemic Patient SARS-CoV-2 SARS-COV-2 infection serious complication thromboembolic complication thromboembolic disease Thromboembolic event thrombosis [DOI] 10.1016/j.amsu.2021.103192 PMC 바로가기 [Article Type] Case Report
First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in SpainSARS-COV-2 델타 (B.1.617.2) 스페인의 임상 징후를 가진 개에서의 우려 변형의 첫 번째 탐지Case Reports Published on 2021-12-162022-09-01 Journal: Viruses [Category] Fulltext, SARS, 변종, 조류인플루엔자, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal B.1.617.2 caused clinical Clinical sign Clinical signs collected concern coronavirus COVID-19 Delta delta variant detection digestive dog indicated Infection Infectious disease Mild Neutralizing antibodies neutralizing antibody oropharyngeal swab pandemic pets predominant reported reservoir reservoirs respiratory reverse zoonosis SARS-CoV-2 SARS-CoV-2 variants Sequencing seroconverted severe acute respiratory syndrome Coronavirus SIGN Spain susceptibility Transmission variant variants of concern Viral Viral load VoC whole-genome sequencing [DOI] 10.3390/v13122526 PMC 바로가기 [Article Type] Case Reports
Viral Acute Anterior Uveitis: Clinical Signs Useful for Differential Diagnosis바이러스성 급성 전방 포도막염: 감별 진단에 유용한 임상 징후Article Published on 2021-11-172023-06-01 Journal: Ocular immunology and inflammation [Category] 대상포진, 두창, 수두, 홍역, [키워드] acute anterior uveitis Clinical signs sensitivity specificity viral etiology [DOI] 10.1080/09273948.2020.1751213
SARS-CoV-2 Infection in One Cat and Three Dogs Living in COVID-19-Positive Households in Madrid, SpainVeterinary Science Published on 2021-11-102022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] Alpha Alpha variant Analysis Asymptomatic B.1.1.7 lineage biochemical Blood bronchoalveolar cat Clinical signs collected Complete coughing COVID-19 COVID-19-positive households cycle threshold determine discharge dog Dyspnea exhibited Fever Genome healthy household IgG response Lineage B.1.1.7 lowest Mild nasal nasopharyngeal Oropharyngeal physical exam positive profiles Real-time reverse-transcription PCR rectal swab remained RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 genome sequencing SARS-COV-2 infection SARS-CoV-2 testing seroconverted serology seronegative Spain variant virus weakness [DOI] 10.3389/fvets.2021.779341 PMC 바로가기 [Article Type] Veterinary Science
Infectious SARS-CoV-2 Is Emitted in Aerosol Particles전염성 SARS-COV-2는 에어로졸 입자에서 방출됩니다Research Article Published on 2021-10-192022-08-31 Journal: mBio [Category] MERS, SARS, 치료제, [키워드] aerosol animal models average breathing carried Clinical sign Clinical signs coronavirus coughing demonstrated disease Evidence hamster hamsters hour Infectious virus majority Mild Particle Particles released respiratory respiratory droplet Respiratory droplets respiratory viruses SARS-CoV-2 sneezing Transmission transmission of SARS-CoV-2 transmitted Viral Viral RNA virus viruses [DOI] 10.1128/mBio.02527-21 PMC 바로가기 [Article Type] Research Article