Clinical treatment – Page 4 – Communicable Diseases Research

Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19

게놈 전체 프로파일링, COVID-19 환자에서 선천적 면역 관련 mRNA의 대체 폴리아데닐화 밝혀냄

Immunology

Published on 2021-10-272022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative polyadenylation alternative splicing APA APA regulator Biomarker cascade category caused Clinical treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production dataset de novo death Diseases effective event highlight human gene human genes human peripheral blood mononuclear cell Immune escape Immunity Infection Infectious diseases Innate innate immune response Innate immunity Interferon-gamma MAPK mechanism mechanisms mononuclear cell mRNA neutrophil neutrophil activation Ontology pandemic patients PBMC performed Peripheral blood Polyadenylation potential therapeutic target Profiling Regulation reported respiratory RNA RNA-seq data SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Variation Viral
[DOI] 10.3389/fimmu.2021.756288 PMC 바로가기 [Article Type] Immunology

ACE2 and Innate Immunity in the Regulation of SARS-CoV-2-Induced Acute Lung Injury: A Review

Review

Published on 2021-10-252022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Research article

Published on 2021-10-222022-10-05
Journal: Cell chemical biology [Category] SARS, 치료제,

[키워드] ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral immunity biotinylated caused Clinical treatment Compound coronavirus coronavirus disease Coronavirus-2 COVID-19 domain drug Epidemic Human human cell humans identify immune responses Infection inhibit Interaction interactome ITGB1 knowledge labeling lysine MAVS mechanism membrane protein methyltransferase mitochondrial mitochondrial antiviral-signaling protein pathway Protein provide proximal proximity labeling replication of SARS-CoV-2 resource reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SET SETD2 significantly the interferon Treatment TurboID viral infection Viral protein
[DOI] 10.1016/j.chembiol.2021.10.008 [Article Type] Research article

Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis-Associated Mechanisms

Review Article

Published on 2021-10-062022-10-29
Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19,

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants

항체 칵테일은 SARS-CoV-2 및 SARS-CoV-2 변이체에 대해 광범위한 중화 활성을 나타냅니다.

Article

Published on 2021-10-012022-09-11
Journal: Virologica Sinica [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 binding activity acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) antibodies antibody antibody cocktail B.1.1.7 B.1.351 B.1.617 binding binding activity binding antibodies Broad neutralization Clinical treatment cocktail conformational convalescent coronavirus COVID-19 patient domain Donor E484K Endemic enzyme epitope immune India indicated L452R linear multiple mutation multiple mutations Mutation N501Y neutralization neutralize Neutralizing activity outbreak overlapped precipitated provided RBD RBD-binding antibody residue residues respiratory risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutic therapeutic antibodies variant variants Viral viral escape
[DOI] 10.1007/s12250-021-00409-4 PMC 바로가기 [Article Type] Article

COVID-19 Mortality Prediction From Deep Learning in a Large Multistate Electronic Health Record and Laboratory Information System Data Set: Algorithm Development and Validation

Original Paper

Published on 2021-09-282022-10-30
Journal: Journal of Medical Internet Research [Category] COVID-19, SARS,

[키워드] 95% CI age Algorithm America Analysis approach AUROC Cardiopulmonary caused characteristic clinical manifestations Clinical treatment Cohort Comorbidity covariate COVID-19 data set death deep deep learning development disease EHR Electronic health record evaluated feature fibrinogen first positive follow-up time hazard ratio Health heterogeneous indicated individual information Kera Laboratory laboratory measurement Laboratory test learning machine learning machine learning model Mayo Clinic Mild Missing data Mortality Neural network nucleic acid test objective oxygen saturation Patient patient population performed predicted prediction provide provided Record recurrent neural networks reducing reported Result retained robust SARS-COV-2 infection serum statistically significant difference Stratification survival Symptom System TensorFlow the SARS-CoV-2 virus the United State Time series Traditional treated validation
[DOI] 10.2196/30157 PMC 바로가기 [Article Type] Original Paper

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

ACE2의 S19W, T27W 및 N330Y 돌연변이는 SARS-CoV-2 S-RBD가 야생형 및 항체 내성 바이러스에 대한 결합과 분자 기반을 강화합니다.

Article

Published on 2021-09-162022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단,

Application of omics technology to combat the COVID‐19 pandemic

Review

Published on 2021-09-162022-10-30
Journal: MedComm [Category] COVID-19,

Follow-Ups on Persistent Symptoms and Pulmonary Function Among Post-Acute COVID-19 Patients: A Systematic Review and Meta-Analysis

Medicine

Published on 2021-09-032022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell lines

Research article

Published on 2021-09-012022-10-05
Journal: Life sciences [Category] 신약개발,

[키워드] ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome calu-3 cells Cell cell line cleavage Clinical treatment Combination coronavirus disease downregulate Effect Emetine enzyme expression flow cytometry human lung human lung cells hydrogen peroxide Infection inhibitor inhibitors knockdown knocked down modulated NAC NF-kappa B NF-κB NF-κB signaling P50 PARP protein expression protein levels pyrrolidine dithiocarbamate reactive oxygen specy receptor reduced renin-angiotensin system reversed ROS RT-qPCR SARS-CoV-2 Significance siRNA suppressed surface Treatment Triclabendazole utility was increased were measured western blotting Zinc zinc supplementation
[DOI] 10.1016/j.lfs.2021.119752 [Article Type] Research article