Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus InfectionOriginal Research Published on 2021-12-092023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] complement evasion complement system Cytokine storm human properdin influenza A virus innate immune system RNA viruses [DOI] 10.3389/fimmu.2021.747654 PMC 바로가기 [Article Type] Original Research
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
Chapter One: Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeuticsBook chapter Published on 2021-11-262022-10-05 Journal: Advances in Immunology [Category] 비임상, [키워드] Activation Adaptive immune response approach approved Avacopan C3 C5 Cell clinical evidence clinical trial complement complement inhibitors complement system Complosome component components conserved Critical Defense deposition eculizumab Evidence greater hallmark Host immune immunology inhibitor Innate immunity investigated Kidney disease Kidney diseases management Pathogens pathophysiological pathway Pathways phylogenetically renal disease required therapeutic agent this system tissue homeostasis tissue injury variety [DOI] 10.1016/bs.ai.2021.09.001 [Article Type] Book chapter
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital DischargeImmunology Published on 2021-11-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] analyzed anaphylatoxin C5a association C5a circulating clinical evolution clinical risk collected complement complement system correlated COVID-19 COVID-19 infection COVID-19 severity Effect eight elevated Evolution Follow-up hospital hospital discharge Hospitalization Hospitalized hospitalized patient infected with SARS-CoV-2 information Innate immunity Level negative correlation pathophysiology Patient reduction respiratory symptom respiratory symptoms SARS-CoV-2 serum Severe case severity Support symptom onset the disease [DOI] 10.3389/fimmu.2021.767376 PMC 바로가기 [Article Type] Immunology
COVID-19, Pre-Eclampsia, and Complement SystemImmunology Published on 2021-11-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 characterized Coagulation system Coagulopathy complement system consequence Contact contribute COVID-19 cross-talk dysregulation endothelial Endothelial cell Endothelial dysfunction Hyperactivation hypercoagulability hyperinflammation immunopathological inflammatory reaction inhibitors Injury MASP-2 mechanism mother multi-organ failure normal pregnancy overlap pre-eclampsia Pregnancy progression prothrombotic provoke receptor ACE2 SARS-CoV-2 SARS-COV-2 infection severity significantly syndrome System Thrombotic events TMPRSS2 treating COVID-19 treatment regimen Vascular virus [DOI] 10.3389/fimmu.2021.775168 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin SystemsSARS-CoV-2는 보체 및 키닌 시스템의 활성화를 통해 COVID-19 병리를 악화시킵니다Immunology Published on 2021-11-052022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] activate Activation acute respiratory syndrome best binding blockade bradykinin C1q classical pathway complement complement system contribute COVID-19 Efficiency ELISA ENCODE generate Genome globular head Human plasma include inflammatory pathway Kallikrein Kallikrein-kinin system Kinin kinin-kallikrein system membrane molecular weight multi-organ failure normal human plasma nucleocapsid peptide peptides platform post COVID “long-haulers” Protein receptor Recombinant protein respiratory SARS-CoV-2 Severe acute respiratory syndrome solid phase SPR structural protein structural proteins surface plasmon resonance System the SARS-CoV-2 therapeutic Treatment treatment of COVID-19 Trigger triggers turn Vasoactive Viral viral particle [DOI] 10.3389/fimmu.2021.767347 PMC 바로가기 [Article Type] Immunology
Functional Activity of the Complement System in Hospitalized COVID-19 Patients: A Prospective Cohort StudyObservational Study Published on 2021-10-282022-10-04 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] 95% CI Activation activity acute lung injury acute phase Admission Alternative pathway Analysis autopsy studies C1 esterase inhibitor collected complement complement system Concentration confounding factors correlated COVID-19 COVID-19 patient Critically ill death Disease progression disease severities disease severity Factor ficolin-3 Follow-up hospitalized COVID-19 patient hospitalized patient ICU admission implicated in vitro in vivo In-hospital death Inflammation Inflammatory marker IQR lectin pathway male mannose-binding lectin mechanical ventilation median multiple comorbidities no significant difference occurred Pathogenesis pathway Patient PCR-confirmed Primary outcome progression Prospective prospective observational study Protein reduced required Result resulting ROC Curve SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 severe disease significantly significantly lower single-center System the patient threshold Ventilation [DOI] 10.3389/fimmu.2021.765330 PMC 바로가기 [Article Type] Observational Study
Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized PatientsArticle Published on 2021-10-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress Admission Algorithm ARDS Biomarker Biomarkers caused Clinical severity complement system Coronavirus disease 2019 Course COVID-19 COVID-19 patients COVID-19 symptomatic patient Critically ill patient death Disease progression evaluated facilitate global pandemic health care systems healthy controls hospital resources Hospitalized ICU intensive care management marker Mild Mild symptom moderate molecular multiple organ failure outcome Patient prediction receptor risk risk stratification in the emergency room SARS-CoV-2 SARS-COV-2 infection Sepsis serum severe cases severe disease severely ill patients spread to suPAR syndrome thrombotic complication urokinase with COVID-19 with mild disease [DOI] 10.3390/jcm10214914 PMC 바로가기 [Article Type] Article
Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals대체 보체 경로 억제가 백신 미접종자에서 폐렴구균 옵소노포고시토시스를 중단시키지만, 백신 접종자에서는 그렇지 않다.Original Research Published on 2021-10-112024-07-30 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] alternative pathway inhibitor complement system Innate immunity microbial immunology Opsonophagocytosis Streptococcus pneumoniae [DOI] 10.3389/fimmu.2021.732146 PMC 바로가기 [Article Type] Original Research
Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections막 보조인자 단백질(MCP; CD46): 결핍 상태 및 병원체 연결Review Published on 2021-10-012022-09-11 Journal: Current opinion in immunology [Category] SARS, 변종, [키워드] 2019 autophagy C3b Cancer cancers CD46 cleave cofactor complement complement system connection contribute coronavirus disease COVID-19 deficiency disease-causing expressed function host cells inflammatory disorders member modulating overexpression pathogen Pathogens Protein receptor Regulatory Serine serine protease T cell T cell activation therapeutic Vaccines variant vectors while [DOI] 10.1016/j.coi.2021.04.005 PMC 바로가기 [Article Type] Review