Thermovaccination: Thermoheliox as an Immune Response Stimulant. Kinetics of Antibodies and C-Reactive Protein Synthesis in Coronaviral InfectionThermovaccination: 면역 반응 자극제로서의 Thermoheliox. 코로나바이러스 감염에서 항체의 동역학 및 C-반응성 단백질 합성Article Published on 2021-05-012022-09-12 Journal: Doklady. Biochemistry and biophysics [Category] 진단, [키워드] affected Analysis antibodies C-reactive protein C-reactive protein (CRP control group Coronaviral coronavirus Coronavirus infection COVID-19 CRP Efficiency eliminating experiment IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M Infection kinetic Kinetic model Kinetics oxygen Patient response shown specific antibody Stimulant synthesis thermoheliox thermovaccination. transfer Treatment [DOI] 10.1134/S1607672921010129 PMC 바로가기 [Article Type] Article
Semicovariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and Other Coronaviruses for Viral Evolution and Characteristics Associated with FatalityArticle Published on 2021-04-232022-10-31 Journal: Information Sciences [Category] COVID-19, [키워드] Algorithm amino acid residue Analysis analyzed B.1.1.7 Beijing canine characteristic Characteristics coefficient complex conserved Coronaviral coronavirus Coronaviruses correlation coefficient Critical domain Evolution example explain extension fatality Fatality rate fluctuations fractional complex moment Frequency GenBank GISAID help increasingly MERS MERS spike protein Mutation negative charge New York Other Pearson correlation coefficient positive positive-correlative and negative-correlative domains Protein provide reveal SARS-CoV-1 SARS-CoV-2 semicovariance coefficient similarity spike Spike protein Spike protein sequence stability statistical strain the spike protein UK variant B.1.1.7 unique variant variants viral evolution virulent virus viruses were used Wuhan Wuhan strain [DOI] 10.3390/e23050512 PMC 바로가기 [Article Type] Article
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signalingNAADP 유발 Ca 2+ 신호에서 JPT2에 대한 필수 요구 사항Article Published on 2021-03-232022-09-11 Journal: Science Signaling [Category] SARS, 유전자 메커니즘, [키워드] acidic organelle acidic organelles Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine component Coronaviral coronaviral entry coronavirus endolysosomal endolysosomal system Essential events homolog identity JPT2 Jupiter nicotinic acid phosphate Protein pseudovirus receptor complex regulate Release required SARS-CoV-2 second messenger sensitivity severe acute respiratory syndrome Coronavirus Signaling translocation [DOI] 10.1126/scisignal.abd5605 PMC 바로가기 [Article Type] Article
The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients회복기 COVID-19 환자의 펩티드 급증을 위한 범 코로나바이러스 항체 개발의 가능성Article Published on 2021-03-062022-09-12 Journal: Archivum immunologiae et therapiae experimentalis [Category] SARS, 진단, [키워드] antibodies bind binding Blood cell entry cellular receptor collected collected data control group control patients convalescent COVID-19 patient Coronaviral coronavirus COVID-19 COVID-9 Cross reactivity cross-reactive antibody cross-reactivity decrease described Developing domain effective ELISA help heptad repeat hidden homology IgG antibody immunogenic immunoglobulins Infection infections inhibitory membrane membrane fusion MERS-CoV Middle East non-infected opposite peptide polyclonal antibody Population Potential presence of antibody raise reactivity recognize respiratory syndrome coronavirus S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection sera seropositive severity similarity spike Spike protein tested the spike protein Vaccine Viral mutations were used [DOI] 10.1007/s00005-021-00607-8 PMC 바로가기 [Article Type] Article
Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus InfectionsArticle Published on 2021-02-172022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Activation alleviate blocking candidate catalytic activity caused complement conducted Consequences conserved contribute Coronaviral coronavirus Coronavirus infections Coronaviruses drug Drug repurposing enzyme human coronavirus Hyperactivation in silico in vitro in vivo Infection inhibitor inhibitory activity Interaction lectin pathway lung Lung injury MASP-2 MERS-CoV Molecular modelling monoclonal antibody N proteins nucleocapsid patients Prevent Protein protein-protein interaction Proteins reduce mortality rate SARS-CoV SARS-CoV-2 screened selected serine protease severe complication Strategy Support targeting tested Treatment triggered [DOI] 10.3390/v13020312 PMC 바로가기 [Article Type] Article
Recombination events are concentrated in the spike protein region of Betacoronaviruses재조합 이벤트는 Betacoronaviruses의 스파이크 단백질 영역에 집중되어 있습니다.Research Article Published on 2020-12-172022-08-13 Journal: PLoS Genetics [Category] Biochemistry, COVID-19, SARS, [키워드] accumulate Alter Analysis analyzed approach Author betacoronaviruses change circulating Coronaviral disease severity engage event events gene flow Genome genomic region genomic variation high mutation rate high mutation rates homoplasies homoplasy host cells host tropism human disease implicated include Interaction likelihood limit limits MERS Mutation mutation rate Mutation rates mutations null model occur polymorphism Polymorphisms Population Positive selection random Recombination recombination event Region RNA virus RNA viruses SARS-CoV-2 sequence similarities sequence similarity shown Spike protein strain Strains subject tested the Sarbecovirus the spike protein variant Viral viruses [DOI] 10.1371/journal.pgen.1009272 PMC 바로가기 [Article Type] Research Article
Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development코로나바이러스 질병 2019-역사적 맥락, 바이러스학, 발병기전, 면역요법 및 백신 개발Review Published on 2020-12-012022-08-31 Journal: Human vaccines & immunotherapeutics [Category] MERS, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus approach Asymptomatic carrier circulating clinical feature Clinical features combating Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease effort epidemiological survey Evidence Human human coronavirus humans immunotherapies Immunotherapy origin other treatment other treatments pandemic pathogen Pathogenesis physician Pneumonia populations prevention of COVID-19 public health researcher respiratory respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread the disease Vaccine Vaccine development viral disease Virology while [DOI] 10.1080/21645515.2020.1787068 PMC 바로가기 [Article Type] Review
Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine ModelReview Published on 2020-11-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome animal animal model betacoronaviruses bovine cause Coronaviral coronavirus CoV CoVs disease dissimilarity Endemic Focusing gastrointestinal disease Gastrointestinal infection Health Host human CoVs knowledge Model Naturally OC43 one health pandemic of COVID-19 respiratory infection review SARS-CoV-2 similarity suggested virus [DOI] 10.3390/pathogens9120991 PMC 바로가기 [Article Type] Review
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1Kallikrein 13은 인간 코로나바이러스 HKU1에 감염되는 동안 프라이밍 프로테아제 역할을 합니다.Research Article Published on 2020-11-242022-09-25 Journal: Science Signaling [Category] 유전자 메커니즘, 진단, [키워드] blocked cause Cell cell culture system cell line cells cellular cleavage cleave cleaved complex Coronaviral coronavirus demonstrated determine distribution effort elements enzyme facilitate HCoV-HKU1 help HKU1 Host host receptor Human human airway epithelial in vitro model Infection Interaction Kallikrein KLK13 mechanism mild respiratory overexpression prevalent primary determinant priming protease Protein receptor regulate required Respiratory disease respiratory epithelial cell S protein S1/S2 SARS-CoV-2 specificity target cells the spike protein These data tissue Transmission viral entry viral pathogenesis viral replication viral S protein virus [DOI] 10.1126/scisignal.aba9902 PMC 바로가기 [Article Type] Research Article
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential201 Published on 2020-11-182022-10-29 Journal: Open Biology [Category] COVID-19, [키워드] (ADP-ribosyl)hydrolase ADP-ribosylation adverse effect alphavirus Analysis Antiviral antiviral poly(ADP-ribosyl)polymerases binding cellular conserved Coronaviral coronavirus COVID-19 cross-reactivity disease drug design evaluate Features homology Host human macrodomain hydrolysis immune response implicated infections kidney Ligand macrodomain Necrosis non-structural protein 3 PARP14 pharmacological post-translational modification raised Regulation SARS-CoV-2 spleen the Coronaviridae therapeutic targets Togaviridae Viral macrodomain Virus Disease were used X domain [DOI] 10.1098/rsob.200237 PMC 바로가기 [Article Type] 201