Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes임상적으로 승인된 약물인 클로르프로마진, 인간 단핵구에서 SARS-CoV-2 뉴클레오캡시드 매개 IL-6 유도 억제Article Published on 2022-06-072022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Acute respiratory failure Affect Antiviral caused chlorpromazine Course COVID-19 COVID-19 pandemic COVID-19 symptom COVID-19 symptoms creating cytokine Cytokine storm Cytokines drug expression human monocyte hyperinflammatory state IL-6 immunomodulatory activity in some induction inhibit interleukin interleukin 6 macrophages monocyte Monocytes neuroleptic NF-κB nucleocapsid protein overcome patients with COVID-19 Pneumonia proinflammatory Respiratory failure resulting Safe SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus nucleocapsid protein secreted secretion Severe infection severe infections Signaling Support target the disease therapy Vaccine [DOI] 10.3390/molecules27123651 PMC 바로가기 [Article Type] Article
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-06-062022-10-05 Journal: Trials [Category] 임상, [키워드] Affect anti-inflammatory agent approved biochemical blood glucose changes in clinical Clinical symptoms clinical trial complete blood count cough COVID-19 COVID-19 complications COVID-19 pandemic creating CRP Curcumin disease double-blind dry cough Dyspnea effective Efficacy headache Health Health status Inflammatory factor Kidney function liver enzymes medication muscular pain not significantly different Outpatient p value parameters patients with COVID-19 piperine Piperine. Placebo placebo group placebo-controlled trial positive Protein Randomized Randomly receive reduce registry severity significantly sore throat sputum the disease two groups weakness with COVID-19 [DOI] 10.1186/s13063-022-06375-w PMC 바로가기 [Article Type] Randomized Controlled Trial
A privacy-aware method for COVID-19 detection in chest CT images using lightweight deep conventional neural network and blockchain경량 심층 기존 신경망과 블록체인을 사용하여 흉부 CT 이미지에서 COVID-19 탐지를 위한 개인 정보 인식 방법Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] 진단, 치료기술, [키워드] Accuracy addition average Blockchain Care Chest CT Chest CT image CNN CNNs COVID-19 COVID-19 epidemic COVID-19 patients creating datasets deep deep learning dissemination evaluated experiment FIVE Health Health care hospital hospitals lack learning network Neural organization organizations platform positive patients Precision privacy professional provide Python Randomly recall receive required Reza Scikit-Learn Spread Tabriz TensorFlow transfer learning virus [DOI] 10.1016/j.compbiomed.2022.105461 PMC 바로가기 [Article Type] Article
Communicating doctors’ consensus persistently increases COVID-19 vaccinations Research Published on 2022-06-012022-10-05 Journal: Nature [Category] 치료법, [키워드] approach associations Consensus COVID-19 COVID-19 vaccination COVID-19 vaccine creating Czech Republic demonstrated effective elicit global public health Health help identifying Impact increase increase in information Intervention Longitudinal data media MONITOR overcome positive prevalent Randomized Spread Treatment vaccination Vaccine Vaccine hesitancy Vaccines widespread [DOI] 10.1038/s41586-022-04805-y [Article Type] Research
Relationship between Acute-Phase Symptoms and Immunoglobulin G Seropositivity up to Eight Months after COVID-19COVID-19 이후 최대 8개월까지 급성기 증상과 면역글로불린 G 혈청양성 간의 관계Article Published on 2022-05-262022-09-11 Journal: Medicina [Category] MERS, 진단, 치료제, [키워드] acute phase adjusted analyzed Anosmia antibody Antibody Response Antibody responses chance classification clinical manifestation COVID-19 creating cross-sectional cross-sectional study dependence determinants Dyspnea effective HCW HCWs healthcare worker highest IgG Immunoglobulin Immunoglobulin G knowledge Logistic regression material Month multiple logistic regression Occurrence Odds ratio post-symptom onset proportion relationship responses S1 and S2 serology testing seronegative Seropositivity significantly increased Spike protein Surveillance Symptom symptom onset tested the spike protein was increased [DOI] 10.3390/medicina58060708 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 Mutations on PCR Assay Sequence AlignmentSARS-CoV-2 돌연변이가 PCR 분석 시퀀스 정렬에 미치는 영향Article Published on 2022-04-282022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] alignment Analysis analyzed assays biosurveillance blind Chain Reaction clinical samples COVID-19 creating diagnosis of COVID-19 diagnostic diagnostics dominant Evidence evidence of failure False negative false negatives functional consequence functional consequences Genome genomic RNA growth highlight identify Impact in silico in viral molecular test Molecular tests Mutation mutations occurred pandemic PCR PCR assay PCR assays polymerase chain polymerase chain reaction preserved proportion Real-time monitoring Real-Time Reverse Transcription Polymerase Chain Reaction Region reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 sequences Sensitivity and specificity sequence sequence identity Sequencing signature statistically sustained therapeutic unique Vaccine variant Viral viral genomes whole genome whole genome sequence Whole genome sequencing [DOI] 10.3389/fpubh.2022.889973 PMC 바로가기 [Article Type] Article
Digital health literacy to share COVID-19 related information and associated factors among healthcare providers worked at COVID-19 treatment centers in Amhara region, Ethiopia: A cross-sectional surveyResearch article Published on 2022-04-142022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료법, [키워드] 95% CI acute respiratory syndrome Affect Analysis conducted CoV COVID-19 COVID-19 outbreak creating cross-sectional survey data entry Digital digital health literacy distribution E-health educational status Ethiopia Factor Health Healthcare provider help identify Improving indicated information less Logistic regression analysis P-value pandemic participated questionnaire reduce respiratory virus Result significantly SPSS statistical significance the vaccine Treatment was used were used [DOI] 10.1016/j.imu.2022.100934 [Article Type] Research article
How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?SARS-CoV-2 변종 RBD의 기본 특성을 향상시키는 점 돌연변이가 전염성과 감염력에 어떤 영향을 미칩니까?Review Published on 2022-04-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors arginine arginine residue arginine residues basic binding affinity cell receptors character charged residues contribute coronavirus coulombic charges COVID-19 creating delta variant difference Effect electrostatic Enhancing glutamic acid host cells increase in Infectivity lysine Mu variant mutations Omicron variant Point Point mutation point mutations RBD RBD-ACE2 Recognition residue Salt Bridge SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spike protein RBD Spike proteins Spread spreading capacity surface electrostatic potential the RBD the SARS-CoV-2 the spike protein Transmissibility variants [DOI] 10.3390/v14040783 PMC 바로가기 [Article Type] Review
Observational Study Exploring the Efficacy and Effectiveness of a New Model of Peer-Assisted Simulation-Based Learning Clinical PlacementObservational Study Published on 2022-04-082022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] adopted benefit Care clinical comparable competency COVID-19 pandemic creating effective evaluated Health learning Model New outcome outcomes participated peer-assisted learning Physiotherapy placement positive prospective observational study provided qualitative data ranged reflected Result Satisfaction simulated patients Simulation suggested translate university utilised was used [DOI] 10.3390/ijerph19084505 PMC 바로가기 [Article Type] Observational Study
In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료Article Published on 2022-04-012022-09-11 Journal: Human gene therapy [Category] COVID19(2023년), SARS, 변종, [키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin [DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article