Decreased Low-Density Lipoprotein Cholesterol Level Indicates Poor Prognosis of Severe and Critical COVID-19 Patients: A Retrospective, Single-Center StudyMedicine Published on 2021-05-262022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Acute cardiac injury Admission Analysis cardiac injury Characteristics Comorbidity Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient critical COVID-19 patients Critically ill patient CRP level death Decreased dysfunction dyslipidemia enrolled four group four groups global public health group Hospitalization ICU immune increased risk Inflammation Injury intensive care LDL-C Level lipoprotein liver dysfunction Low-density lipoprotein Low-Density Lipoprotein cholesterol Lymphocyte count mechanical ventilation Mortality not differ Patient Pearson correlation Poor poor prognosis positively correlated Prognosis proportion reduction renal dysfunction severe and critical COVID-19 patients severe patients Shock shown Symptom treated [DOI] 10.3389/fmed.2021.585851 PMC 바로가기 [Article Type] Medicine
Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019호중구는 코로나바이러스 질병 2019에서 폐를 손상시키기 위해 세포외 트랩을 설정합니다Editorial Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar ARDS Blood chemokine chemokines contribute correlated Course COVID-19 COVID-19 patients critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients deteriorate disease disease severity fatal COVID-19 ICU admission implicated Inflammatory marker inflammatory markers investigated Lower respiratory tract LRT lung tissue marker NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Pathogenesis pathology patients peaked plasma produced respiratory distress retained SARS-CoV-2 SARS-CoV-2 RNA sputum syndrome thrombosis [DOI] 10.1093/infdis/jiab053 PMC 바로가기 [Article Type] Editorial
Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019T 헬퍼 17 및 T 헬퍼 1 세포의 빈도 감소 및 중요한 코로나바이러스 질병 2019와의 연관성Article Published on 2021-05-012022-09-12 Journal: Apmis [Category] SARS, 진단, [키워드] association Cell cellular immunity Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical critical COVID-19 patient difference disease dysregulated evaluate flow cytometry Frequency healthy controls healthy subject immune responses knowledge moderate-to-severe patient not significant Patient Peripheral blood severity of COVID-19 significant difference significantly subject Subtypes T helper T helper 1 T helper 17 Th1 Th17 Th17 cell Treg Treg cell Treg cells were measured [DOI] 10.1111/apm.13129 PMC 바로가기 [Article Type] Article
The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients입원 시 실험실 검사의 특성과 중증 및 중증 코로나19 환자의 불리한 임상 결과에 대한 위험 요인Research Article Published on 2021-04-202022-09-01 Journal: BMC Infectious Diseases [Category] MERS, 진단, [키워드] 95% CI Admission age blood cell Characteristics Clinical characteristics Clinical outcome coronavirus disease Coronavirus disease 2019 correlated COVID-19 Cox proportional hazard Cox proportional hazards model Critical critical COVID-19 patient critical COVID-19 patients demonstrated diagnosed died Disease progression enrolled evaluate high mortality rate hospital increased mortality independent risk factor independent risk factors indicated Invasive mechanical ventilation involved Laboratory results Laboratory test Laboratory tests morbidity morbidity and mortality Mortality multivariable Older age oxygen Oxygen therapy Patient patients with COVID-19 performed proportional hazards model public health emergency required Result Retrospective study risk risk factor Risk factors White blood cell white blood cell count Wuhan Wuhan, China [DOI] 10.1186/s12879-021-06057-z PMC 바로가기 [Article Type] Research Article
The effectiveness of continuous renal replacement therapy in critical COVID-19 patients with cytokine release syndrome: a retrospective, multicenter, descriptive study from Wuhan, ChinaResearch Paper Published on 2021-04-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury Adsorption AKI C-reactive protein consolidation Continuous Continuous renal replacement therapy convalescent plasma COVID-19 COVID-19 patient critical COVID-19 patient CRRT CRS cytokine release Cytokine release syndrome D-dimer death decrease develop dialysis disease Effectiveness elevated evaluated Factors Fatality rate filtration hospital Inflammation Inflammatory cytokine Inflammatory marker kidney LASSO Lung CT multicenter neutrophil count neutrophil counts organ Patient Protective reduced renal replacement therapy Respiratory failure Result retrospective risk factor severe complication significantly Spread syndrome the patient Wuhan Wuhan, China [DOI] 10.18632/aging.202838 PMC 바로가기 [Article Type] Research Paper
Exploration of prognostic factors for critical COVID-19 patients using a nomogram model노모그램 모델을 사용한 중증 코로나19 환자의 예후 요인 탐색Article Published on 2021-04-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료법, [키워드] advanced age Analysis analyzed blood cell C-reactive protein coronavirus disease Coronavirus disease 2019 COVID-19 Critical critical COVID-19 patient critical COVID-19 patients death death group demographic data Diseases exploration Factor finding High-sensitivity C-reactive protein hs-CRP Intervention laboratory biomarker laboratory biomarkers Logistic regression analysis lymphocyte Lymphocyte count mortality risk multiple logistic regression Multiple logistic regression analysis nomogram Patient Platelet Platelet count predict Prognosis Prognostic factor ranged reduce mortality regression analysis risk factor Risk factors screened survival was performed WBC White blood cell [DOI] 10.1038/s41598-021-87373-x PMC 바로가기 [Article Type] Article
Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells내피 전구체의 다차원 단백질체 접근은 CD19 세포로 제한된 KDR의 발현을 보여줍니다Clinical Trial Published on 2021-04-012022-08-31 Journal: Stem cell reviews and reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] absence Abstract approach artificial heart B-lymphocyte B-lymphocytes Bioprosthetic total artificial heart Blood C-kit cadherin candidate cardiovascular disease cardiovascular diseases CD133 CD14 CD19 CD34 CD45 Cell cell population cells cellular circulating circulation classic complementary Cord blood COVID-19 COVID-19 severity Critical critical COVID-19 patient cytometric Cytometry demonstrated described Elimination endothelial Endothelial progenitor cell Endothelial progenitor cells Endothelial progenitors evaluate events expresse expressed expressing expression Flow flow cytometry healthy imaging immature induce involved KDR lead Lineage Lymphocytes marker moderate monocyte Monocytes multidimensional one patient Patient performed Peripheral blood phenotype Population positive cell progenitor progenitor cell progenitor cells proteomic quantified redistribution Restricted Single Cell STEM stem cell stem cells subpopulation subset Subtypes vasculogenesis VE-cadherin VEGFR-2/KDR. [DOI] 10.1007/s12015-020-10062-1 PMC 바로가기 [Article Type] Clinical Trial
Computing infection distributions and longitudinal evolution patterns in lung CT images폐 CT 이미지에서 감염 분포 및 종단 진화 패턴 계산Research Published on 2021-03-232022-09-01 Journal: BMC Medical Imaging [Category] 진단, [키워드] Absorption Algorithm automatically average calculated change collected Community community acquired community acquired pneumonia computing consolidations coronavirus disease Coronavirus disease 2019 Coronavirus infections Course COVID-19 Critical critical COVID-19 patient critical COVID-19 patients dataset Dice disease disease course distribution effective enlargement Evolution GGO groups Infection Inpatients intensive care lesion lower lobe lung Lung CT Lung infection Onset patients performed Pneumonia Probability progression provide Quantitative radiologist Region Registration Result right lower lobe Segmentation severe COVID-19 severe COVID-19 patient severe COVID-19 patients significant difference Spread statistically subpleural subsequent supplementary material Template the disease Visualization [DOI] 10.1186/s12880-021-00588-2 PMC 바로가기 [Article Type] Research
Judicious use of low-dosage corticosteroids for non-severe COVID-19: A case reportCase Report Published on 2021-03-192022-10-28 Journal: Open Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome Administered administration of corticosteroid antiviral drugs ARDS attenuate Case report chest CT scan China complete recovery Coronavirus disease 2019 Corticosteroid corticosteroid therapy COVID-19 COVID-19 case COVID-19 disease critical COVID-19 patient Cytokine storm death Disease progression dosage Efficacy Evidence facilitated immunosuppressive infection with SARS-CoV-2 Inflammatory lack lung Lung inflammation Lung injury Methylprednisolone Personalized medicine progression reduction in Regular Respiratory failure retrospective Safe SARS-CoV-2 Severe case supportive care syndrome systemic corticosteroid Therapeutic approach therapy Treatment use of corticosteroid was recorded WHO [DOI] 10.1515/med-2021-0250 PMC 바로가기 [Article Type] Case Report
Proteomic blood profiling in mild, severe and critical COVID-19 patients경증, 중증 및 중증 COVID-19 환자의 단백질체 혈액 프로파일링Comparative Study Published on 2021-03-182022-08-31 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome analyses ARDS Autoimmune Biomarker Blood blood protein blood proteins changes in CKAP4 Control COVID-19 COVID-19 cases COVID-19 disease COVID-19 positive patient Critical critical COVID-19 patient death Differential expression analysis disease Disease progression disease severity generate group identify IL-1ra IL6 in some individual individuals infected individuals Infection Inflammation LILRB4 Mild mild respiratory mild respiratory tract infection MONITOR multi-organ failure nine Olink PD-L1 potential therapeutic targets progression Protein proteomic proteomics respiratory respiratory distress respiratory tract infection SARS-CoV-2 pandemic severe pneumonia significantly syndrome the disease viral infection Visualization was performed [DOI] 10.1038/s41598-021-85877-0 PMC 바로가기 [Article Type] Comparative Study