Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity Research Published on 2022-07-152022-10-05 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] 28-day mortality acute respiratory syndrome Admission affected baseline Blood BMI body mass index C-reactive protein C-terminal caused changed chronic inflammation Clinical outcome collected Concentration concentrations coronavirus Coronavirus disease 2019 Critically ill Critically ill patient CRP disease course higher risk ICU Inflammatory biomarker intensive care investigated marker mechanisms MR-proADM Netherland no significant difference not different obesity Observational cohort study outcome Patient patients with obesity PCT procalcitonin Result retrospective SARS-CoV-2 SARS-CoV-2 pneumonia significantly suggested the disease ventilator WBC [DOI] 10.1038/s41366-022-01184-2 [Article Type] Research
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19Observational Study Published on 2022-07-012022-10-04 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] 임상, [키워드] Admission C-reactive protein Characteristics characteristics of patient characterized cohorts collected constipation coronavirus disease COVID-19 COVID-19 patient Critical Critically ill patient defined demographic data diarrhea energy balance energy deficit Enteral faster gastrointestinal function Hospital stay hypophosphatemia ICU ICU protocol in both group Infection intestinal intubation less Lipid men Mortality mortality rate neuromuscular blockade non-respiratory organ nutrition obese obese patients Patient patients patients with COVID-19 patients without COVID-19 Prone position propofol proportion prospective observational study Protein reduced refeeding syndrome risk Screening Sedation severity scores significantly more SOFA score SOFA scores Specific syndrome target underfeeding. variables with COVID-19 [DOI] 10.1002/jpen.2334 PMC 바로가기 [Article Type] Observational Study
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness케모카인, 가용성 PD-L1 및 면역 세포 저반응은 SARS-CoV-2 중병의 뚜렷한 특징입니다Article Published on 2022-07-012022-09-12 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ARDS C-reactive protein CCL17 CCL26 cellular checkpoint pathway chemoattractant comparison coronavirus disease Coronavirus-2 COVID-19 Critical Critically ill patient CRP CXCL10 demographics enrolled feature hyporesponsiveness identify IFN-γ IL-10 IL-17A IL-6 IL-8 immune Immune cell immune signature in vitro Interaction less lymphocyte Migration molecular monocyte mortality rate multisite not significantly different p value Patient patients patients without COVID-19 PD-L1 plasma Pneumonia profile prospective cohort Regulatory SARS-CoV-2 SARS-CoV-2-positive patient SARS-CoV-2-positive patients Sepsis severe respiratory failure severity subject subjects T cell T-cell TNF-α two groups ventilator-free day with COVID-19 [DOI] 10.1152/ajplung.00049.2022 PMC 바로가기 [Article Type] Article
Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational StudyObservational Study Published on 2022-07-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] abnormality acute respiratory distress age clinical Coma COVID-19 COVID-19 ARDS patients COVID-19 patients Critical care Critically ill patient delayed awakening delirium dominant dysfunction France Frequency ICU Ill interquartile range male measurement median Mortality neurologic Neurologic examination outcome Paris Patient patients Prevalence Prognostic value Prospective reactivity respiratory Sedation syndrome ventilator-free day with COVID-19 [DOI] 10.1097/CCM.0000000000005491 PMC 바로가기 [Article Type] Observational Study
Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19Research article Published on 2022-07-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상, [키워드] addition amoxicillin Anti-bacterial agents Antibiotics benefit CD4+ CD8+ clarithromycin Clinical effect Co-incubation confounder COVID COVID-19 COVID-19 patients Critical care Critically ill patient Cytokines decrease Effect Ex vivo had no healthy hospital ICU patient IFN-alpha IL-10 IL-2 IL-6 immunomodulation immunomodulatory immunomodulatory properties immunomodulatory property in viral increase in infections intensive care intracellular cytokine investigated lymphocyte Macrolide monocyte no effect PBMC phagocytosis reduction in mortality Result retrospective cohort study SARS-CoV-2 Spike protein stimulated synergistic T cell response TNF-alpha Univariate analysis was performed with COVID-19 [DOI] 10.1016/j.jiac.2022.04.001 [Article Type] Research article
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review
Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patientsResearch article Published on 2022-07-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 바이오마커, [키워드] acute respiratory syndrome addition ARDS association cause caused Clinical sign COVID-19 Critically ill Critically ill patient critically ill patients cross-sectional death Disseminated intravascular coagulopathy distress evaluate group hemorrhage Hospitalized hospitalized patients hypoxia Infection Laboratory lung dysfunction occurred outcome parameter Patient patients with COVID-19 Pneumonia radiological evidence Respiratory failure risk Severe acute respiratory syndrome Severe patient severity severity of COVID-19 statistically statistically significant difference symptomatic patient syndrome systemic illness thrombocytopenia virus was done [DOI] 10.1016/j.amsu.2022.103973 [Article Type] Research article
Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort studyResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 바이오마커, [키워드] 28-day mortality assumed benefit Clinical outcome Cohort cohort study comparable cost-effectiveness Covid cytokine storm COVID-19 COVID-19 patient Critically ill Critically ill patient CRP demonstrated Dexamethasone dose equity family feasible finding fixed dose foundation funding groups Inflammation inhibitor interleukin-6 no significant difference pair-wise comparison Patient patients physiological response receiving reduce mortality reduction response Scholarship severe COVID-19 supported Taylor the patient threshold Tocilizumab treated with COVID-19 [DOI] 10.1016/j.lana.2022.100228 [Article Type] Research article