Gene ontology – Page 4 – Communicable Diseases Research

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다

Article

Published on 2022-01-292022-09-11
Journal: Cardiovascular Research [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular Docking

Medicine

Published on 2022-01-202022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE2 ACE2 binding ADRB2 Against Analysis anti-SARS-CoV-2 baicalein China Chinese Chinese medicine component Compound COVID-19 cross database differentially expressed gene enrichment analysis expression FOS Frequency Gene ontology GeneCards highest HMOX1 Hydrogen bond hydrophobic ICAM1 identify IL6 immune immune function immune-related gene immunization ingredient Interaction JUN KEGG Kyoto lung adenocarcinoma molecular docking molecular target National Health Commission network network pharmacology NFKBIA NHC nine objective Occurrence overlapped overlapping performed Pharmacology platform positively correlated Potential potential mechanism prescription Result screened selected Stat1 target target gene TCM TCMSP therapeutic target UniProt viral transcription was used were used with COVID-19
[DOI] 10.3389/fmed.2021.813119 PMC 바로가기 [Article Type] Medicine

Identification of the Key Immune-Related Genes in Chronic Obstructive Pulmonary Disease Based on Immune Infiltration Analysis

면역 침윤 분석을 기반으로 한 만성 폐쇄성 폐 질환의 주요 면역 관련 유전자 식별

Article

Published on 2022-01-042022-09-11
Journal: International journal of chronic obstructive pulmo [Category] SARS, 유전자 메커니즘,

[키워드] activated AHNAK Algorithm Analysis biological processe Biomarker cause of death chronic chronic obstructive chronic obstructive pulmonary disease CIBERSORT complex mechanism conducted COPD coronavirus disease coronavirus disease COVID-19 correlation Correlation analysis correlations CXCR1 CXCR2 database dataset death defined DEGs dendritic cell dendritic cells Diagnosis diagnostic biomarker Diagnostic biomarkers differentially expressed gene Differentially expressed genes downloaded enrichment analysis expressed FCGR3B follicular fraction Fractions Functional enrichment analyses Functional enrichment analysis Gene ontology Genes greater helper T cell hub genes identification Immune cell immune cells immune-related gene immune-related genes immune-related genes. Ingenuity Pathway Analysis Interaction investigated IPA IRGs KEGG Kyoto lung tissue morbidity neutrophil Neutrophils NK cells Obstructive obstructive pulmonary disease pathway Pathways Patient potential mechanism PPI progression proportion proportions protein-protein interaction pulmonary pulmonary disease significantly SLIT2 subset T cells Treatment
[DOI] 10.2147/COPD.S333251 PMC 바로가기 [Article Type] Article

Systems Biology and Bioinformatics approach to Identify blood based signatures molecules and drug targets of patient with COVID-19

Research article

Published on 2021-12-302022-10-05
Journal: Informatics in Medicine Unlocked [Category] 바이오마커,

[키워드] acute respiratory syndrome approach association AURKB bioinformatics Biology Biomarker Biomarker signatures Blood blood cell Blood cells Blood common gene BUB1B CCNB1 Cell connection contagious Coronavirus-2 COVID-19 dataset DEGs diagnose differentially expressed gene Differentially expressed genes disease DLGAP5 drug target effective Gene Expression Gene ontology HJURP hub protein Identified identify infected with SARS-CoV-2 Infection KIF11 Microarray molecular MONITOR mononuclear cell NCAPG New coronavirus Ontology pathophysiology pathway patient with COVID-19 patients with COVID-19 PBMCs PBMCs cell performed Peripheral blood prevalence of COVID-19 progression Research SARS-CoV-2 signaling pathways subjects System therapeutic intervention TOP2A TPX2 transcript transcriptomic Treatment TTK with COVID-19
[DOI] 10.1016/j.imu.2021.100840 [Article Type] Research article

Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling Pathways

COVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석

Research Article

Published on 2021-12-242022-09-10
Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization
[DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article

An integrative bioinformatics analysis for identifying hub genes associated with infection of lung samples in patients infected with SARS-CoV-2

SARS-CoV-2에 감염된 환자의 폐 샘플 감염과 관련된 허브 유전자 식별을 위한 통합 생물정보학 분석

Research

Published on 2021-12-172022-09-11
Journal: European Journal of Medical Research [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach approaches Bioinformatics analysis biological processe biological processes BPS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set DDX58 DEGs differentially expressed gene Differentially expressed genes EGR1 function functions Gene ontology Genes genomes GO analysis GSE147507 Guidance Health Organization hub genes human body identify IFIH1 IFITM1 immune responses infected with SARS-CoV-2 Infection International Intersection ISG15 KEGG Kyoto lung OASL online tool pathophysiological mechanism Patient performed PHEIC PPI PPI network processed programming Protein–protein interaction Protein–protein interactions network public health emergency respiratory Result SAMD9 SAMD9L SARS-CoV-2 SARS-COV-2 infection screened selected severe acute respiratory syndrome Coronavirus severity STRING supplementary material TNFSF10 turn Viral viral infection WHO World Health Organization XAF1
[DOI] 10.1186/s40001-021-00609-4 PMC 바로가기 [Article Type] Research

Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis

차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견

Case Study

Published on 2021-11-172022-09-01
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome
[DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study

Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis

유전자 공동 발현 네트워크 분석에 기초한 코로나 바이러스 (SARS-COV-2)에 대한 약물 재생

Article

Published on 2021-11-082022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute respiratory syndrome analyses Analysis applied approach Asia candidate drug candidate drugs cisplatin co-expression Computational models contagious coronavirus Cyclophosphamide database disease drug Drug repurposing Drug screening drugs drugs targeting effective drug effective drugs FIVE FLUOROURACIL gene co-expression network Gene ontology Genes Genome Interaction list METHYLDOPA Microarrays miRNA miRNAs reconstructed respiratory Respiratory illness retrieved SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 disease Severe acute respiratory syndrome Sirolimus Systems biology target gene the SARS-CoV-2 transcription factor transcription factors treat Treatment Viral viral respiratory virus
[DOI] 10.1038/s41598-021-01410-3 PMC 바로가기 [Article Type] Article

Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection

Research article

Published on 2021-11-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종,

[키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread
[DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article

Network-driven analysis of human– Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets

네트워크 기반의 인간-플라스모디움 파르시파룸 상호작용체 분석: 말라리아 약물 발견 및 인 실리코 타겟 추출을 위한 과정

Research

Published on 2021-10-262024-08-08
Journal: Malaria Journal [Category] 말라리아,

[키워드] drug resistance Gene ontology Genomics malaria Multi-omics Protein–protein interaction
[DOI] 10.1186/s12936-021-03955-0 PMC 바로가기 [Article Type] Research