Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?Covid-19 예후 및 감수성과 숙주 유전적 연관성에 대한 체계적인 검토: 2020년에 우리는 무엇을 배웠습니까?Review Published on 2022-03-012022-09-11 Journal: Reviews in Medical Virology [Category] SARS, 변종, [키워드] ABO ACE1 ACE2 analyzed ApoE association associations available data candidate candidate gene candidate genetic variants claimed clinical manifestation complex interaction COVID-19 COVID-19 prognosis COVID-19 severity database disease Effects eligible environmental factors evaluated examined Exome exome sequencing FIVE furin Genes Genetic genetic association Genetic association studies genetic variants GWAS Health healthcare heterogeneous HLA Host IFITM3 IFNL3 IFNL4 IMPROVE indicated Infection locus Meta-analysis moderate outcome outcomes pathophysiology performed Polymorphisms predict Prognosis recommendations reduce replicate Replication reported Research SARS-CoV-2 SARS-COV-2 infection Sequencing severity susceptibility TMPRSS2 whole-genome [DOI] 10.1002/rmv.2283 PMC 바로가기 [Article Type] Review
Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks인공신경망을 이용한 코로나19 환자 중환자실 입원 및 사망률의 유전적 예측Article Published on 2022-03-012022-09-11 Journal: Journal of Cellular and Molecular Medicine [Category] 변종, [키워드] absence ADAMTS13 age age and gender ANN artificial intelligence Artificial neural network C3a CD46 CD55 CFB CFD CFH CFHR1 CFI Clinical outcome clinical outcomes complement complement inhibition coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical death death in COVID-19 develop disintegrin dysregulation examined Gender Genes Genetic genetic susceptibility genetic susceptibility. Genetic variant genetic variants Hospitalization Hospitalized ICU identified variant identify metalloproteinase morbidity morbidity and mortality Mortality motif Next-generation sequencing outcome Patient patients phenotype presence or absence recruited SARS-CoV2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly increased THBD thrombomodulin Thrombospondin unmet need variant variants [DOI] 10.1111/jcmm.17098 PMC 바로가기 [Article Type] Article
Computational investigation reveals that the mutant strains of SARS-CoV2 have differential structural and binding properties전산 조사에 따르면 SARS-CoV2의 돌연변이 균주는 차등적인 구조 및 결합 특성을 가지고 있습니다Article Published on 2022-03-012022-09-11 Journal: Computer methods and programs in biomedicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] approaches binding binding affinity caused computational method Computational methods Course docking exhibited functional genetic variants host protein Infection manifested MD simulation mechanism molecular molecular basis molecular dynamics mutant mutant strain Mutant strains network network analysis over pandemic Pathogenesis persistent infection Protein protein structure protein-protein interaction RBD Receptor binding domain reveal SARS-CoV2 Scientific community Severe acute respiratory syndrome strain Structure Transmission utility V367F V483A variant variants virus wildtype [DOI] 10.1016/j.cmpb.2021.106594 PMC 바로가기 [Article Type] Article
ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in MenACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant [DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology
Worldwide SARS-CoV-2 haplotype distribution in early pandemicResearch Article Published on 2022-02-162022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Analysis characterized clade clades Clustering concomitance confirmed case COVID-19 COVID-19 disease COVID-19 pandemic dataset deaths described distribution early phase early stage Effect effort evaluated Evolution fatality Genetic genetic variants genomic geographical distribution globe Haplotype Infection large-scale analysis majority Missense Mutation occur other variants pandemic patients reported SARS-CoV-2 selective sequence single mutation Spread synergistic the S protein to define Transmission variant viral outbreak viral strain virus Wuhan [DOI] 10.1371/journal.pone.0263705 PMC 바로가기 [Article Type] Research Article
Effectiveness of inactivated SARS-CoV-2 vaccine (CoronaVac) on intensive care unit survival중환자실 생존에 대한 비활성화된 SARS-CoV-2 백신(CoronaVac)의 효과Original Paper Published on 2022-02-092022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] Admission admitted to ICU arterial blood arterial blood gas Blood blood gas clinical CoronaVac coronavirus disease Coronavirus disease 2019 Course COVID-19 eligible enrolled evaluated ferritin ferritin level ferritin levels genetic variants group had no hospital Hospital mortality Hospital stay ICU inactivated intensive care intensive care unit investigated Laboratory Lactate lactate dehydrogenase Length Mortality National no effect not different on admission parameters Patient patients protective effect radiological Radiological parameters SARS-CoV-2 pandemic SARS-CoV-2 vaccine Sinovac survival target population vaccination vaccination schedule Vaccine [DOI] 10.1017/S0950268822000267 PMC 바로가기 [Article Type] Original Paper
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
An update on host immunity correlates and prospects of re-infection in COVID-19Review Published on 2021-12-282023-07-02 Journal: International reviews of immunology [Category] SARS, [키워드] COVID-19 genetic variants Reinfection SARS-CoV-2 Vaccines [DOI] 10.1080/08830185.2021.2019727 PMC 바로가기 [Article Type] Review
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study멘델식 무작위 배정 연구에서 지질 저하 약물과 COVID-19 결과의 연관성Research Article Published on 2021-12-062022-09-10 Journal: eLife [Category] 변종, 신약개발, 치료제, [키워드] 95% CI 95% confidence interval Analysis approach association associations benefit Blood calculate carried causal relationship caused cholesterol clinical trial confounding bias COVID-19 COVID-19 hospitalization COVID-19 pandemic death decrease drug drugs eLife estimates Evidence expression expression quantitative trait loci faster fat funding genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study higher risk HMGCR Hospitalization Hospitalized Human Hypothesis identify in viral infected with SARS-CoV-2 Infection infections LDL cholesterol Lipid lipid metabolism lipid-lowering drugs loci low-density Low-density lipoprotein mendelian randomization Mendelian randomization studies Mendelian randomization study metabolism Mortality MR study NPC1L1 Odds ratio outcome Patient PCSK9 positive protective effect Quantitative reduce reduced risk SARS-CoV-2 SARS-COV-2 infection severe disease SMR statins suggested susceptibility target gene Target genes treating COVID-19 university variable Viral viral infections virus were used with COVID-19 [DOI] 10.7554/eLife.73873 PMC 바로가기 [Article Type] Research Article
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers고도로 노출되었지만 감염되지 않은 의료 종사자 사이에서 SARS-CoV-2에 대한 감수성에서 ACE2 유전적 다형성의 역할Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] A allele ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 COVID-19 COVID-19 patients drug target evaluate Evaluating Genetic Genetic polymorphism Genetic variant genetic variants healthcare worker help hospitalized patient identify increased risk individual polymorphism role SARS-CoV-2 SARS-COV-2 infection selected single-nucleotide single-nucleotide polymorphism SNP susceptibility susceptible T allele uninfected variant with COVID-19 [DOI] 10.1080/22221751.2021.1902755 PMC 바로가기 [Article Type] Article