Immunogenicity and Safety of a 3-Dose Regimen of a SARS-CoV-2 Inactivated Vaccine in Adults: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial성인을 위한 SARS-CoV-2 비활성화 백신의 3회 용량 요법의 면역원성 및 안전성: 무작위, 이중 맹검, 위약 대조 2상 시험Clinical Trial Published on 2022-05-162022-09-12 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 3-dose regimen acute respiratory syndrome Adults Adverse AEs antibody Antibody Response Control coronavirus dose doses double-blind Effective vaccines elicited event geometric mean titer GMT GMTs immune response immunogenicity Immunoglobulin inactivated Inactivated vaccine Injection-site pain intensity Neutralizing Neutralizing antibodies Older pandemic percentage Phase 2 Placebo placebo-controlled trial predominant pseudovirus Randomized receive Receptor binding domain robust Safety safety profile SARS-CoV-2 SARS-CoV-2 inactivated vaccine second dose separated serious AE tested the vaccine vaccination Vaccine virus were recorded [DOI] 10.1093/infdis/jiab627 PMC 바로가기 [Article Type] Clinical Trial
Sex-associated differences between BMI and SARS-CoV-2 antibody titers following the BNT162b2 vaccineBNT162b2 백신 후 BMI와 SARS-CoV-2 항체 역가 간의 성별 관련 차이Article Published on 2022-05-012022-09-12 Journal: Obesity (Silver Spring, Md.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI anti-SARS-CoV-2 antibody Antibody Response Antibody titer asked BMI BMI category BNT162b2 BNT162b2 vaccine COVID-19 vaccine decrease dose Efficacy geometric mean titer GMT Health care worker high risk IgG IgG antibody titer information Interaction investigated Linear regression analysis men obesity outcomes participated Pfizer questionnaire SARS-CoV-2 antibody SARS-CoV-2 spike serological survey severe COVID-19 Sex significantly spike spike IgG tested vaccination Vaccine was used women [DOI] 10.1002/oby.23417 PMC 바로가기 [Article Type] Article
Immunogenicity and Safety of the COVID-19 Vaccines Compared With Control in Healthy Adults: A Qualitative and Systematic ReviewRandomized Controlled Trial Published on 2022-05-012022-10-04 Journal: Value in health : the journal of the International [Category] 비임상, 유전자 메커니즘, 임상, [키워드] 6 hour acute respiratory syndrome adverse event adverse events all-cause mortality antibody conducted Control control arm control group Controlled trial coronavirus COVID-19 COVID-19 vaccine death disease dose elicited emergence evaluate examined fatigue females Fever for inclusion geometric mean titer GMT GMTs group headache highest immune response immunogenicity Immunoglobulin Infection local reaction Mild mRNA-1273 neutralizing antibody Pain pandemic Placebo postvaccination profiles Qualitative ranged reaction reported retrieved review Safety seroconversion rates severe adverse event subject systematic review the healthy tolerable vaccination Vaccine Vaccines while [DOI] 10.1016/j.jval.2021.09.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida플로리다의 암 환자에서 SARS-CoV-2 mRNA-1273 백신 접종에 대한 항체 반응 평가Article Published on 2022-05-012022-09-12 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI age anti-CD20 anti-CD20 treatment antibody Antibody Response applied blood test calculated Cancer cancer diagnosis cancer type cohort study diagnose dose doses English enzyme-linked immunosorbent Factor geometric mean titer hematologic Hispanic IgG IgG level Immunosuppressive treatment individual lowest lymphocyte lymphoid monoclonal antibody treatment morbidity and mortality mRNA-1273 Older outcome participant Patient patients treated Patients with cancer receipt receiving response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Seroconversion Seropositivity significantly lower small molecule solid tumor Spanish T Test treated Treatment vaccination vaccine dose vaccine response white [DOI] 10.1001/jamaoncol.2022.0001 PMC 바로가기 [Article Type] Article
Correlation of Immunogenicity and Reactogenicity of BNT162b2 and CoronaVac SARS-CoV-2 VaccinesBNT162b2와 CoronaVac SARS-CoV-2 백신의 면역원성과 반응성의 상관관계Article Published on 2022-04-272022-09-12 Journal: mSphere [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval adverse event AEs analyzed Antibody Response antibody response against BNT162b2 BNT162b2 vaccine CoronaVac correlation COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Day Efficacy elicit female females Fever Frequency Gender geometric mean titer GMT headache Health help immunogenicity Infection injection site injection site pain itching joint Live virus local reaction male males men microneutralization Neutralizing Neutralizing antibodies neutralizing antibody of BNT162b2 Pain pandemic participant population immunity reactogenicity receiving recorded SARS-CoV-2 Side effect Side effects tiredness vaccination Vaccine Vaccine hesitancy Vaccines was determined while women [DOI] 10.1128/msphere.00915-21 PMC 바로가기 [Article Type] Article
Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccinationSARS-CoV-2에 대한 백신 유도 체액 반응은 급격히 감소했지만 세포 면역은 BNT162b2 백신 접종 후 6개월까지 유지되었을 가능성이 있습니다.Article Published on 2022-04-262022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 50% neutralization titer 95% CI 95% confidence interval age alcohol alcohol consumption BNT162b2 Cell cell count Cell-mediated immunity cellular immunity completion coronavirus coronavirus disease coronavirus disease-2019 correlated declined dose elevated ELISPOT ELISpot assay evaluate evaluated Gender geometric mean geometric mean titer geometric mean titers healthy subject humoral IgG Immunoglobulin Immunoglobulin G interferon interferon-γ Interferon-γ releasing ELISpot assay median age neutralization neutralization titer neutralizing antibody of BNT162b2 parameter patients remained SARS-CoV-2 SARS-CoV-2 spike protein SFC Spike protein subjects vaccination vaccine-induced antibodies vaccine-induced antibody variant variant of concern [DOI] 10.1016/j.vaccine.2022.03.057 PMC 바로가기 [Article Type] Article
Neutralization and durability of 2 or 3 doses of the BNT162b2 vaccine against Omicron SARS-CoV-2Omicron SARS-CoV-2에 대한 BNT162b2 백신 2~3회 중화 및 내구성Article Published on 2022-04-132022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Antibody neutralization BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine dose effective geometric mean geometric mean titer GMT GMTs neutralization neutralization durability neutralize of BNT162b2 omicron Pfizer Pfizer vacine SARS-CoV-2 serum spike glycoprotein Support tested USA-WA1/2020 vaccinated individual vaccinated individuals Vaccination strategy variants virus viruses wild-type wild-type SARS-CoV-2 [DOI] 10.1016/j.chom.2022.02.015 PMC 바로가기 [Article Type] Article
Evaluation of Immunogenicity by Pseudovirus Neutralization Assays for SARS-CoV-2 Variants after Primary and Booster Immunization1차 및 추가 접종 후 SARS-CoV-2 변이체에 대한 슈도바이러스 중화 분석에 의한 면역원성 평가Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] baseline blood sample Blood samples booster booster dose collected COVID-19 COVID-19 vaccine determine disease dose Effectiveness enrolled evaluate Follow-up geometric mean geometric mean titer geometric mean titers GMT GMTs immune response immune responses immunization immunogenicity IMPROVE inactivated Inactivated COVID-19 vaccine instance NAb NAbs neutralization Neutralizing antibodies neutralizing antibody other variant other variants participant Participants peaked Primary and booster immunization Pseudovirus neutralization assay Pseudovirus neutralization assays reached Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose seroconversion rate seroconversion rates Spike protein status strain the spike protein the vaccine titers vaccination variant variants were measured within 6 months Wuhan Wuhan-Hu-1 [DOI] 10.1016/j.ijid.2022.01.068 PMC 바로가기 [Article Type] Article
BNT162b2 Third Booster Dose Significantly Increases the Humoral Response Assessed by Both RBD IgG and Neutralizing Antibodies in Renal Transplant RecipientsBNT162b2 3차 부스터 용량은 신장 이식 수혜자의 RBD IgG 및 중화 항체 모두에 의해 평가된 체액 반응을 상당히 증가시킵니다Article Published on 2022-03-212022-09-11 Journal: Transplant International [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Allograft antibody Antibody Response BNT162b2 BNT162b2 vaccine booster COVID-19 COVID-19 vaccine develop Diabetic diabetic nephropathy Dilution domain dose effective ESRD geometric mean geometric mean titer geometric mean titers GMT GMTs group had no humoral Humoral response IgG Immunosuppression increase independent predictor independent predictors mycophenolic acid negative and positive nephropathy Neutralizing antibodies neutralizing antibody non-responder non-responders of BNT162b2 Patient positive predictor pseudo-virus RBD RBD IgG Receptor-binding domain recipient recipients remained renal Renal transplantation Responder responders response response rate SARS-CoV-2 secondary to seroconverted significant increase stratified systemic systemic AEs the vaccine Transplant Vaccine were recorded [DOI] 10.3389/ti.2022.10239 PMC 바로가기 [Article Type] Article
Immune response to one dose of BNT162b2 mRNA Covid-19 vaccine followed by SARS-CoV-2 infection: An Italian prospective observational studyObservational Study Published on 2022-03-152022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] anti-SARS-CoV-2 Antibody Response Biological biological risk BNT162b2 mRNA vaccine carried categories control group COVID-19 dose European country first dose geometric mean titer GMT HCW HCWs Health healthcare worker Healthcare workers immunization immunized individual Infection initiated Italian Italy mRNA Observational cohort study of BNT162b2 positive PPE prospective observational study risk SARS-CoV-2 serological statistically significant difference surveillance data tested the antibody response the vaccine Two-arm vaccination Vaccinations Vaccine vaccine group was determined were infected [DOI] 10.1016/j.vaccine.2022.02.002 PMC 바로가기 [Article Type] Observational Study