A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19SARS-CoV-2와 hemophagocytic lymphohistiocytosis 유전자의 상호 작용에 대한 네트워크 기반 분석은 COVID-19의 혈전증 매개체로서 호중구 세포외 트랩을 가리킵니다.Research Article Published on 2021-03-082022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] abnormal coagulation acting Adults Algorithm Algorithms Analysis approach children circulating co-morbidities co-morbidity Coagulation concert condition consequence COVID-19 described disease Diseases Endothelium environmental condition environmental conditions Epidemic extracellular trap extracellular traps favor feature Genetic genetic information H1N1 H1N1 influenza hematologic hemophagocytic lymphohistiocytosis HLH Host host gene hyperinflammation Hypothesis identify Immune cell immune cells increase increased risk individual inflammatory condition inflammatory conditions inflammatory process inflammatory signal inflammatory signals Influenza information Interaction life-threatening likelihood manuscript mechanism mediators Metabolic disorders morbidities NET NETs network neutrophil Neutrophils Pathogenesis pathogenic pathway Pathways potential mechanism potential molecular predict presenting problem Pulmonary thromboembolism regulate responsible risk SARS-CoV-2 serious complication severe COVID-19 severely ill patient severely ill patients similarities similarity tested Thromboembolism thrombosis thrombotic thrombotic complication Thrombotic complications trajectory underlying condition underlying conditions vascular thrombosis Viral protein Viral proteins [DOI] 10.1371/journal.pcbi.1008810 PMC 바로가기 [Article Type] Research Article
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new IssueCOVID-19 관련 사이토카인 폭풍 증후군 및 진단 원칙: 오래된 문제와 새로운 문제Review Published on 2021-02-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen Autoimmune disease Autoimmune diseases autologous benefit Bone marrow CAR-T Characteristics chimeric chimeric antigen receptor claimed clinical experience Clinical sign Clinical signs clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRS CSS cytokine cytokine release Cytokine release syndrome Cytokine storm Cytokine storm syndrome Cytokines Deterioration diagnosed diagnoses diagnosing Diagnosis diagnostic Diagnostic Criteria disease early stage early stages Evolution familial/primary hemophagocytic lymphohistiocytosis hemophagocyte hemophagocytic lymphohistiocytosis hemophagocytic syndrome HLH include issue less limitation Macrophage macrophage activation macrophage activation syndrome malignancy mechanisms non-specific paper Pathogenesis Patient Research respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis sensitivity severe acute respiratory syndrome Coronavirus sHLH Signs and symptoms Symptoms T-cell T-cell receptor therapy [DOI] 10.1080/22221751.2021.1884503 PMC 바로가기 [Article Type] Review
COVID-19: High-JAKing of the Inflammatory “Flight” by Ruxolitinib to Avoid the Cytokine StormOncology Published on 2021-01-082022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] Activation admitted to ICU approach approved CAR-T caused COVID-19 COVID-19 mortality COVID-19 patient CRS cytokine cytokine release deleterious effect dendritic cells evaluated events ferritin fibrosis graft-versus-host-disease hematologic hematological high mortality HLH Hospitalization hyperinflammation ICU IL-6 immune-cell Immunotherapy impacted IMPROVE Italy Jak JAK1 JAK2 janus kinase limit lymphocyte Macrophage management Migration molecular molecular mechanism multi-organ failure myelofibrosis outbreak outcome overcome pathogenic Patient Proinflammatory cytokine reducing Respiratory failure ruxolitinib SARS-CoV-2 selective Signaling solid tumor storm syndrome tissue damage TNFα treated Treatment turn virus [DOI] 10.3389/fonc.2020.599502 PMC 바로가기 [Article Type] Oncology
Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinibarticle Published on 2020-11-302024-09-01 Journal: International journal of infectious diseases : IJID : official publication [Category] 말라리아, [키워드] Hemophagocytosis HLH JAK/STAT JAK1/2 inhibition Malaria tropica [Article Type] article
Title: Cytokine release syndrome is not usually caused by secondary hemophagocytic lymphohistiocytosis in a cohort of 19 critically ill COVID-19 patientsArticle Published on 2020-10-262022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 임상, [키워드] absence Admission Analysis appear approach ARDS assessment caused Clinical course Cohort Course courses COVID-19 COVID-19 patient criteria Critically ill CRS Cytokine release syndrome Cytokines death declining Diagnostic Criteria discharge dominant feature Fever HLH hyperinflammation Hyperinflammatory ICU immunology immunosuppressive implication IMPROVE independent Infection Inflammation Innate immune cells Innate immunity macrophage activation syndrome median neutrophil neutrophilic observation period outcomes over Patient reached Respiratory failure secondary hemophagocytic lymphohistiocytosis severe disease sHLH subgroups of patient syndrome tested therapy Trajectories Treatment virus were assessed [DOI] 10.1038/s41598-020-75260-w PMC 바로가기 [Article Type] Article
Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case reportCase Report Published on 2020-10-152022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] abrogated Admission biochemical blockade C-reactive protein Case report clinical picture coronavirus disease COVID-19 criteria decrease described develop eight elevated ferritin Fever FIVE hemophagocytic lymphohistiocytosis HLH hyperinflammation Hyperinflammatory IL-6 Immune thrombocytopenia Immune-mediated IMPROVE induce inflammatory parameter intensive care interleukin-6 interleukin-6 receptor lactate dehydrogenase majority Manifestations measurement monoclonal antibody Patient patient with COVID-19 performed Pulmonary function purpura quantification Randomized controlled trials Respirator Respiratory failure Respiratory illness severe COVID-19 Specific syndrome therapeutic thrombotic Tocilizumab treated Treatment [DOI] 10.1186/s13256-020-02503-9 PMC 바로가기 [Article Type] Case Report
Assessment of the Haemophagocytic lymphohistiocytosis HScore in patients with COVID-19Article Published on 2020-09-282023-06-18 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, [키워드] COVID-19 Cytokine storm HLH HScore [DOI] 10.1093/cid/ciaa1463 PMC 바로가기
Natural Killer Cell Dysfunction and Its Role in COVID-19Review Published on 2020-09-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated acute respiratory distress acute viral infection ARDS Autoimmunity Cancer cardiovascular disease cardiovascular diseases Cell cells clearance clinical manifestation Complication COVID-19 COVID-19 case COVID-19 patient Critical Cytokine storm died Elderly patient extreme Factor function HLH immune immune dysregulation immune response immune system inflammation markers Inflammatory cytokine inflammatory phenotype instance majority Mild modulating natural Natural killer cells NK cell overcome pathogen Patient patient groups Precision reduction in required restoration resulting role SARS-CoV-2 SARS-COV-2 infection severe disease syndrome viral infection [DOI] 10.3390/ijms21176351 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection–Associated Hemophagocytic Lymphohistiocytosis An Autopsy Series With Clinical and Laboratory CorrelationArticle Published on 2020-07-182023-07-01 Journal: American journal of clinical pathology [Category] SARS, [키워드] 2019-nCoV Autopsy coronavirus COVID-19 hemophagocytic lymphohistiocytosis Hemophagocytosis HLH SARS-CoV-2 [DOI] 10.1093/ajcp/aqaa124 PMC 바로가기
Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?Opinion Published on 2020-07-152022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] “cytokine storm” acute respiratory distress acute respiratory syndrome ARDS caused characterized Clinical characteristics clinical symptom conditions coronavirus Coronavirus disease 2019 cough Course COVID-19 cytokine release death disease Diseases Dyspnea fatigue Fever hemophagocytic lymphohistiocytosis HLH hyperinflammation Hyperinflammatory syndrome identify immunosuppressive IMPROVE Infection infections Inflammatory Inflammatory response Laboratory test life-threatening majority malignancies mild symptoms multi-organ failure myalgia outcomes Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 Pneumonia rheumatological SARS-CoV-2 screened Severe case severe COVID-19 syndrome therapy triggered [DOI] 10.1186/s12916-020-01682-y PMC 바로가기 [Article Type] Opinion