T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Admission Analysis B cell CD4+ T cell circulating Course COVID-19 creatinine Critical Critical disease decrease disease elevated higher risk Hospitalized hospitalized COVID-19 patient identify IL-6 immune response increased risk Infection marker men no significant difference Older Patient patients hospitalized percentage plasma predict progressed progression Result risk SARS CoV2 subset T cell T-cell Th17 cell Th17 cells therapy These data Tocilizumab two group women worsening [DOI] 10.1016/j.ejim.2022.06.001 [Article Type] Research article
Acute delirium as an initial manifestation of COVID-19 patients with acute ischemic stroke: Report on two casesCase report Published on 2022-08-012022-10-05 Journal: Journal of the Formosan Medical Association = Taiw [Category] COVID19(2023년), SARS, 진단, [키워드] Acute delirium acute ischemic stroke acute respiratory syndrome affective AIS Brain Complication coronavirus coronavirus disease COVID-19 COVID-19 patient D-dimer level delirium diagnose Diagnosis diagnostic diffusion disorder elevated Hospitalized hospitalized COVID-19 patient Hypercoagulopathy Infection initial magnetic resonance imaging management manifestation Neurological complication Neuropsychiatric Patient Psychiatric Psychiatric symptom reperfusion report SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum stroke Symptom Symptoms therapeutic therapy time-consuming [DOI] 10.1016/j.jfma.2022.01.025 [Article Type] Case report
Impact of surgical mask on performance and cardiorespiratory responses to submaximal exercise in COVID-19 patients near hospital discharge: A randomized crossover trialRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Clinical rehabilitation [Category] 임상, [키워드] activity Borg cardiorespiratory Care coronavirus coronavirus disease COVID-19 COVID-19 and coronavirus disease COVID-19 patient COVID-19 patients discharge Dyspnoea evaluate had no hospital hospital discharge hospitalized COVID-19 patient hospitalized patient Impact mandatory measure mitigate not significant parameter Patient performed physical physical activity raise Randomized recovering from COVID-19 recruited rehabilitation repetition response Safe significantly higher sit-to-stand test submaximal exercise test surgical surgical mask Transmission Trial wearing were measured were recorded [DOI] 10.1177/02692155221097214 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pulmonary embolism severity index predicts adverse events in hospitalized COVID-19 patients: A retrospective observational study: PESI/sPESI and COVID-19 StudyResearch article Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 진단, 치료기술, [키워드] 95% confidence interval acute respiratory distress Admission adverse event adverse events age Analysis can be used cause clinically clinically suspected COVID-19 death evaluated hospital hospitalized COVID-19 hospitalized COVID-19 patient in-hospital mortality in-hospital mortality rate incidence independent risk factor intensive care invasive investigated measurement mechanical ventilation multivariate logistic regression noninvasive objective Odds ratio participant patients with COVID-19 polymerase chain positive predict Pulmonary embolism pulmonary embolism severity index (PESI) Respiratory distress syndrome Result retrospective scoring system sensitivity setting severity simplified PESI (sPESI) specificity study population syndrome the median Thromboembolic event venous Venous Thromboembolism women [DOI] 10.1053/j.jvca.2022.08.009 [Article Type] Research article
Characteristics of procalcitonin in hospitalized COVID-19 patients and clinical outcomes of antibiotic use stratified by procalcitonin levels입원한 코로나19 환자에서 프로칼시토닌의 특성과 프로칼시토닌 수치로 계층화된 항생제 사용의 임상적 결과Article Published on 2022-08-012022-09-11 Journal: Internal and Emergency Medicine [Category] 바이오마커, [키워드] antibiotic antibiotic use Antibiotics Bacterial bacterial co-infection baseline characteristics Characteristics clinical Clinical outcome clinical outcomes Cohort COVID-19 COVID-19 patient COVID-19 severity Critically ill Cutoff disease do not intubate do not resuscitate elevated examined excluded Factor group hospital hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU patient Infection intensive care mechanical ventilation median microbiologically non-critically ill patient non-critically ill patients non-ICU NPV oxygen Oxygen requirement Patient PCT performed PPV pro-calcitonin procalcitonin procalcitonin level renal renal disease retrospective review significantly significantly higher status stratified Tocilizumab use of antibiotics utility [DOI] 10.1007/s11739-022-02955-5 PMC 바로가기 [Article Type] Article
Hypocalcemia: A key biomarker in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: Biomedical journal [Category] SARS, 바이오마커, [키워드] addition Admission adult subject Arterial hypertension association Biochemical biomarkers Biomarker blood biochemical calcium calcium concentration Cancer cardiovascular diseases China Chronic diseases Chronic kidney disease chronic obstructive CKD clinical complication Cohort collected Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CVD diabetes effective enrolled evaluated hospital hospitalizations hospitalized COVID-19 patient Hypocalcemia identify indicated ionized calcium mandatory material mechanical ventilation obesity outcome parameter Pathologies pathology patients poor prognosis positive correlation presence of comorbidity Previous studies profile Prognosis prognostic biomarker pulmonary disease Result SARS-CoV2 serum severity syndrome the disease [DOI] 10.1016/j.bj.2022.08.005 [Article Type] Research article
Obesity and clinical outcomes in COVID-19 patients without comorbidities, a post-hoc analysis from ORCHID trialClinical Trial Published on 2022-07-292022-10-04 Journal: Frontiers in Endocrinology [Category] 임상, [키워드] 95% CI adjusted Analysis BMI Clinical outcome Comorbidities Comorbidity COVID-19 COVID-19 in patient COVID-19 patient Cox regression Cox regression analysis death deaths defined described died discharge Effect Evidence hazard ratio hospital hospitalized COVID-19 patient individual Inpatient multivariate obese obesity occurred post-hoc analysis Prognosis Prospective trial required significantly Trial was used with COVID-19 worse prognosis [DOI] 10.3389/fendo.2022.936976 PMC 바로가기 [Article Type] Clinical Trial
A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients입원한 코로나19 환자의 면역 체계 반응 및 I형 인터페론 신호 전달 경로에 대한 종합 평가Article Published on 2022-07-162022-09-12 Journal: Cell Communication and Signaling : CCS [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract association autoantibody B lymphocyte CD4 CD8 conditions conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine decrease downstream dysregulation ELISA enrolled enzyme-linked immunosorbent evaluate evaluated expression expression level Factor flow cytometry Frequency healthy controls healthy individual hospitalized COVID-19 patient IFN-I IFN-I signaling IFN-α IFN-β IL-10 IL-17 IL-1β IL-6 illness Illness severity Immune cell immune system Immune-phenotype investigated IRF life-threatening material Mild Mild symptom NK cell NK cells Numerous Pathogenesis pathway Patient positive Protein protein levels Real-time PCR reduced Regulatory RNA SARS-CoV2 sera severity signaling molecule signaling molecules signaling pathway significant decrease Th17 TNF-α Treatment Treg Treg cell Vaccines virus [DOI] 10.1186/s12964-022-00903-6 PMC 바로가기 [Article Type] Article
Antiphospholipid antibodies and vitamin D deficiency in COVID-19 infection with and without venous or arterial thrombosis: A pilot case-control study정맥 또는 동맥 혈전증이 있거나 없는 COVID-19 감염의 항인지질 항체 및 비타민 D 결핍: 파일럿 사례 대조 연구Article Published on 2022-07-142022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] antibody Anticoagulant anticoagulation antiphospholipid antibody Autoimmune disorders case-control study Chronic kidney disease Control COVID-19 COVID-19 infection COVID-19 patient deficiency Effect End-stage renal disease enrolled evaluate Future hospitalized COVID-19 patient hospitalized COVID-19 patients in both groups malignancy measure mechanisms Myocardial infarction Patient positive reducing Sex significantly more stroke syndrome therapy Thromboembolic event Thromboembolic events Thromboembolism thrombosis venous vitamin D deficiency vitamin D level were excluded were measured [DOI] 10.1371/journal.pone.0269466 PMC 바로가기 [Article Type] Article
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent Corona virus coronavirus disease Coronavirus-2 COVID-19 COVID-19 disease COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine RAS pathway receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article