Efficacy and harms of tocilizumab for the treatment of COVID-19 patients: A systematic review and meta-analysis코로나19 환자 치료를 위한 토실리주맙의 효능과 유해성: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] 임상, 진단, [키워드] 95%CI adverse event adverse events AEs all-cause mortality analyses antibody Arm ARMS benefit bleeding Clinical improvement Clinical outcome Cohort cohorts Controlled trial COVID-19 COVID-19 adult patient COVID-19 adult patients database disease severity Effect evaluated Evidence Hospitalized hospitalized COVID-19 patients IL-6 impacted inverse main analyses mechanical ventilation Meta-analysis methodology moderate neutropenia nine no significant difference Other outcome performed Placebo Primary outcomes Probability Quality Random-effects meta-analysis Randomized controlled trials RCT RCTs receptors reduced risk risk of bia RoB searched severe AEs significant difference significantly Standard of care Subgroup analyses subgroup analysis systematic review TCZ thrombotic thrombotic event Thrombotic events Tocilizumab Treatment Weighting worsening [DOI] 10.1371/journal.pone.0269368 PMC 바로가기 [Article Type] Meta-Analysis
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patientsSARS-CoV-2의 지속적인 바이러스 RNA 방출은 입원한 COVID-19 환자의 섬망 발병률 및 6개월 사망률과 관련이 있습니다Article Published on 2022-06-012022-09-12 Journal: GeroScience [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI age BMI Chronic kidney disease Corticosteroid COVID-19 COVID-19 hospitalization delirium Diabetes Mellitus diagnosis of COVID-19 dysfunction Factor hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient implication In-hospital incidence increasingly initial Logistic regression Male sex Medicine Mortality occur Occurrence outcome Patient persistent positive predictor remained SARS-CoV-2 SARS-CoV-2 RT-PCR severity shedding significantly Viral RNA shedding viral shedding [DOI] 10.1007/s11357-022-00561-z PMC 바로가기 [Article Type] Article
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients입원한 COVID-19 환자의 혈장에서 프롤린 특이적 펩티다제 활성(DPP4, PRCP, FAP 및 PREP)Article Published on 2022-06-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] MERS, 바이오마커, 진단, [키워드] Activation activities activity Alpha Biomarker changes in collected coronavirus COVID-19 COVID-19 patient COVID-19 patients decrease dipeptidyl peptidase Dipeptidyl peptidase 4 discharge DPP4 dysregulated dysregulation elevated FAP feature fibroblast Fibroblast activation protein alpha Follow-up healthy control healthy controls Hospital admission Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients immune system investigated pathophysiological patients peptidase plasma PRCP PrEP proline Prolyl oligopeptidase Prolylcarboxypeptidase. Protein remained Sepsis Septic shock significantly significantly increased significantly lower utility were measured while [DOI] 10.1016/j.cca.2022.03.005 PMC 바로가기 [Article Type] Article
Risk of Death in Comorbidity Subgroups of Hospitalized COVID-19 Patients Inferred by Routine Laboratory Markers of Systemic Inflammation on Admission: A Retrospective Study입원 시 전신 염증의 일상적인 실험실 지표에 의해 추론된 입원한 COVID-19 환자의 동반 질환 하위 그룹의 사망 위험: 후향적 연구Article Published on 2022-05-312022-09-11 Journal: Viruses [Category] MERS, 바이오마커, [키워드] Admission Analysis AUC Cluster cluster analysis Comorbidities Comorbidity confounding factor confounding factors correlation correlations COVID-19 COVID-19 mortality COVID-19 patients disease severity Factor hierarchical cluster analysis hospitalized COVID-19 patients Inflammatory inflammatory markers Laboratory laboratory parameter lymphocyte marker Model Mortality mortality risk neutrophil Neutrophil-to-lymphocyte ratio NLR on admission parameter Platelet positive positive correlations predict predictors recorded Regression model risk risk of death ROC Curve routine severity severity predictors. shown SII single-center study subgroup subgroups systemic systemic immune-inflammation index systemic inflammation WBC [DOI] 10.3390/v14061201 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients입원한 COVID-19 환자의 호기에서 SARS-CoV-2 RNAArticle Published on 2022-05-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition breath contagiousness contribute COVID-19 demonstrated distress droplets epidemiological studies feasible hospitalized COVID-19 patient hospitalized COVID-19 patients Infection management nasopharyngeal pandemic Patient patients required respiratory distress Saliva SARS-CoV-2 RNA SARS-CoV-2 transmission Spread throat swab Transmission Viral Viral detection virus [DOI] 10.1038/s41598-022-13008-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severityArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] Adaptive immunity Affect Blood cellular COVID-19 COVID-19 patients cytokine response Dexamethasone disease severity domain Hospital stay hospitalized COVID-19 patients humoral Humoral response IFN-α2 IgA IgG IgM IgM and IgG IL-12p70 immune immune component immune parameter immune response immunopathology infection with SARS-CoV-2 Inflammation mechanism neutralization Neutrophils not affect Peripheral blood plasma Prognosis respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization activity Seroconversion sputum subset therapy Treatment viral infection [DOI] 10.1038/s41467-022-30088-y PMC 바로가기 [Article Type] Article
Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study기계 학습 기반 병원 내 COVID-19 질병 결과 예측기(CODOP) 개발 및 평가: 다대륙 후향적 연구Article Published on 2022-05-172022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] allocation AUROC breakthrough infections calibrated Clinical outcome clinical parameter clinical utility clinically Cohort cohort of patient Computational biology country COVID-19 COVID-19 disease COVID-19 patient deaths development disperse effective heterogeneous hospital Hospital admission hospital resources Hospitalization hospitalizations hospitalized COVID-19 patients Human In-hospital Latin Latin America machine-learning maintain Medicine New offer outcome pandemic patient cohort patient cohorts prediction Predictive Retrospective study risk stratification SARS-CoV-2 variants sensitivity Spain specificity Systems biology tested Triage USA vaccination vaccination rate Vaccination Status variant virus waning immunity [DOI] 10.7554/eLife.75985 PMC 바로가기 [Article Type] Article
Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes-A Single-Center Experience and a Brief Review of the LiteratureCOVID-19 환자의 낮은 혈청 비타민 D는 염증 마커 및 환자의 결과와 관련이 없습니다-단일 센터 경험 및 문헌에 대한 간략한 검토Review Published on 2022-05-102022-09-11 Journal: Nutrients [Category] MERS, 바이오마커, [키워드] Admission age association C reactive protein Comorbidities Comorbidity correlation COVID-19 CRP disease disease severity evaluate except for experience ferritin fibrinogen form forms groups highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers IQR Laboratory laboratory procedures leukocytes literature median Mild Mild disease moderate Patient Peripheral blood peripheral blood leukocytes Prospective Study review Serum level serum levels severe COVID-19 significantly significantly higher significantly lower stratified subject Vitamin D vitamin D level vitamin D levels vitamin D serum Vitamin D status was collected was performed were assessed [DOI] 10.3390/nu14101998 PMC 바로가기 [Article Type] Review
Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19Research article Published on 2022-05-012022-10-05 Journal: Clinical neurophysiology : official journal of the [Category] 바이오마커, 유전자 메커니즘, [키워드] abnormality Cohort collected Comorbidities COVID-19 COVID-19 pandemic COVID-19 patient Critical died discharge EEG electroencephalogram Electroencephalography epileptiform Factor Hemorrhagic Stroke hospital hospitalized COVID-19 patient hospitalized COVID-19 patients increasing age indication Injury MOST NeuroCOVID New York City nonspecific objective occurred outcome Patient patients patients with COVID-19 performed Result retrospective Risk factors Seizure Seizures severe COVID-19 Significance stroke Treatment [DOI] 10.1016/j.clinph.2022.03.001 [Article Type] Research article
Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia입원한 COVID-19 환자와 정상 인지, 경도 인지 장애 또는 알츠하이머 치매가 있는 비 COVID-19 환자의 혈청 신경퇴행성 바이오마커 비교Article Published on 2022-05-012022-09-11 Journal: Alzheimer's & dementia : the journal of the Alzhei [Category] MERS, 바이오마커, [키워드] Acidic Alzheimer's disease amyloid beta Biomarker Biomarkers Cognitive impairment Complication Control correlated COVID COVID patient Covid patients COVID-19 COVID-19 patient Dementia died discharge home discharged home disease elevated Encephalopathy GFAp Glial fibrillary acidic protein hospitalized COVID-19 patient hospitalized COVID-19 patients In-hospital In-hospital death light chain marker Mild Mortality neurodegeneration neurodegenerative neurofilament light chain Neurological complications outcome Patient phosphorylated Protein SARS-CoV-2 serum severity significantly significantly lower subject survival tau. UCHL1 [DOI] 10.1002/alz.12556 PMC 바로가기 [Article Type] Article