human body – Page 4 – Communicable Diseases Research

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway

SARS-CoV-2는 JAK-STAT 경로에서 근위 요소를 방해합니다

Article

Published on 2021-09-092022-09-11
Journal: Journal of Virology
[Category] Coronavirus, SARS, 유전자 메커니즘, 진단,

“Molecular Masks” for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry

SARS-CoV-2 바이러스 진입을 효과적이고 안전하게 차단하는 ACE2용 "분자 마스크"

Article

Published on 2021-08-202022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applicability block blocked blood pressure cause Cell cell surface receptor Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G decrease derivative dimeric enzyme enzyme activity Health Health crisis Human human body human cell human cells Infection Interaction mutant normal blood pressure peptoids pseudovirus Regulation respiratory resulting Safe SARS-CoV-2 SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein surface receptor these compound these compounds unique Vaccine virus
[DOI] 10.3390/ijms22168963 PMC 바로가기 [Article Type] Article

Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro Systems

SARS-COV-2 펩티드 및 LPS- 활성화 된 인간 시험 관내 시스템에서 살릭 피질 추출물 및 아세틸 살리실산의 비교 항 염증 효과

Comparative Study

Published on 2021-06-232022-08-31
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 치료제,

[키워드] Salix species Acetylsalicylic acid acetylsalicylic acid (ASA) acid activated Anti-inflammatory anti-inflammatory drug Anti-inflammatory drugs Anti-inflammatory effects anti-inflammatory treatment Cell cells co-culture Comparative compounds cortex COVID-19 patient Culture cytokine Cytokines Effect Efficacy enzyme activity Extract Fever Human human body human PBMC IL-10 IL-1β IL-6 IMPROVE in vitro in vitro data Inflammation Inflammatory ingredient intestinal liver cell LPS-activated mediator metabolism outcome Pain PBMCs peptide peptides PGE PGE₂ precursor prostaglandin prostaglandin E2 protein expression retained salicin salicylic acid SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides suppressed suppression System therapy Willow willow bark
[DOI] 10.3390/ijms22136766 PMC 바로가기 [Article Type] Comparative Study

Interpretation of laboratory tests for prevention of the SARS-CoV-2 transmission

SARS-CoV-2 전파 방지를 위한 실험실 검사 해석

Article

Published on 2021-06-012022-09-11
Journal: Journal of anesthesia
[Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol applied Care cause Chain Reaction Clinical practice Cluster coronavirus coronavirus disease Coronavirus disease 2019 detect discharge disease enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays Epidemiology higher infectivity hospital hospitals human body Infection Laboratory test Laboratory tests lung nose polymerase chain polymerase chain reaction positive Prevent Probability provided reduce reproductive Research reverse transcription reverse transcription polymerase chain reaction SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 stability sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specificity Spread Statistics Statistics. the patient the SARS-CoV-2 Transmission transmission of SARS-CoV-2 understanding uninfected Universal
[DOI] 10.1007/s00540-020-02872-x PMC 바로가기 [Article Type] Article

Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

면역 체계 강화에 Nagella sativa(블랙 커민)의 잠재적인 영향: COVID-19 전염병을 늦추기 위한 희망

Review

Published on 2021-05-012022-08-31
Journal: Phytomedicine : international journal of phytother
[Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory distress syndrome Anti-inflammatory antioxidant ARDS benefit black Black seed component components coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical Cytokines disease severity Effect Evidence FDA approved Drugs human body immune immune modulation immune regulation immune response immune system immunomodulation indicated infected with COVID-19 intensive care intensive care unit modulation molecular molecular docking Molecular docking study Mortality Nagella sativa New coronavirus Nigella Sativa Nigellidine Obstructive pandemic pathophysiology Patient Potential pro-inflammatory cytokine pro-inflammatory cytokines provided respiratory respiratory disorders respiratory distress Respiratory distress syndrome severe cases severity Symptom the disease thymoquinone treat Treatment Vaccine α-hederin α-hederin.
[DOI] 10.1016/j.phymed.2020.153277 PMC 바로가기 [Article Type] Review

Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils

호중구의 항바이러스 능력에 대한 I형 인터페론 매개 조절

Review

Published on 2021-04-292022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 치료제,

[키워드] acute respiratory syndrome Antigen presentation Antiviral antiviral immune response antiviral responses antiviral therapeutics balance Cell complex contribute coronavirus coronavirus disease COVID-19 damage Defense Epidemic Evidence example Host host antiviral response host defense human body IFN IFNs immune resistance immune responses Inflammation initiate Interaction interferons interferons (IFNs) Like mechanism mechanisms neutrophil Neutrophil extracellular trap Neutrophils pandemic receptor receptors regulate Research respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 tissue tissue damage Tolerance TRAP Treatment Type type I interferon Viral viral infection viral infections virus viruses
[DOI] 10.3390/ijms22094726 PMC 바로가기 [Article Type] Review

Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

COVID-19 환자의 SARS-CoV-2 RNA의 사후 사후 매핑 및 조직 손상과의 상관 관계

Research Article

Published on 2021-03-302022-09-10
Journal: eLife
[Category] SARS, 진단, 치료기술, 치료제,

[키워드] accumulate addition Autopsies Autopsy Blood blood clotting bloodstream cause caused circulating clinical clinical observations coronavirus correlation COVID-19 Deceased detect died disease dissemination distribution drug treatment drug treatments early post-mortem interval effective example experiment extrapulmonary tissue feature help histology host response human body Hypothesis immune reaction impacted Infection Inflammation involved leads lung tissue Lungs more difficult Multiorgan dysfunction New coronavirus observation organ organs other organ other organs pathophysiology Patient patients with COVID-19 performed postmortem examination postmortem examinations postmortem interval Protein provide question regions remained Research SACs sampling SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Support systemic disease tissue tissue damage tissue degradation tissues transmission electron microscopy Travel Viral Viral load viral particle Viral RNA Viremia virus were used while
[DOI] 10.7554/eLife.60361 PMC 바로가기 [Article Type] Research Article

The Double Edge Sword of Testosterone’s Role in the COVID-19 Pandemic

COVID-19 팬데믹에서 테스토스테론의 역할이라는 양날의 검

Review

Published on 2021-03-162022-09-11
Journal: Frontiers in Endocrinology
[Category] MERS, 유전자 메커니즘,

COVID-19 Detection from Chest X-ray Images Using Feature Fusion and Deep Learning

기능 융합 및 딥 러닝을 사용하여 흉부 X선 이미지에서 코로나19 감지

Article

Published on 2021-02-202022-09-12
Journal: Sensors (Basel, Switzerland)
[Category] MERS, 진단,

[키워드] Accuracy Algorithm Analysis anisotropic diffusion ANN approach caused chest X-ray Chest X-ray images China CNN Convolutional neural network convolutional neural network (CNN) coronavirus COVID-19 Cross-validation death rate deaths decrease deep deep learning demonstrated detect detection develop Diagnosis diffusion disease feature Fracture fused fusion histogram histogram-oriented gradient (HOG) human body Image impair input learning Novel coronavirus number of deaths obvious symptoms overfitting patient’s death provided reduced Research responsible sensitivity specificity Spread SVM thought was used watershed segmentation Wuhan X-ray X-ray image
[DOI] 10.3390/s21041480 PMC 바로가기 [Article Type] Article

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다

Research Article

Published on 2021-01-252022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent
[DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article