ISG15

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research