Alternative therapies for Covid-19Research article Published on 2021-08-052022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, 치료제, [키워드] Alternative treatment Antiviral bloodstream caused clinical trials coronavirus COVID-19 effective Health killing mechanism outbreak overcome Radiation radiation therapy therapy treatment for COVID-19 virus [DOI] 10.1016/j.matpr.2021.07.501 [Article Type] Research article
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairmentSARS-CoV-2는 인간 췌장 β 세포를 감염시키고 β 세포 손상을 유발합니다Article Published on 2021-08-032022-09-11 Journal: Cell Metabolism [Category] SARS, 바이오마커, [키워드] ACE2 Apoptosis apoptotic attenuate beta cell Cell Cell signaling cells coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity demonstrated diabete diabetes elicit Evidence expressed expression Factor impairment in vitro indicate induce infect insulin islet killing neuropilin neuropilin 1 NRP1 pancreatic pancreatic beta cell pandemic Pathway analysis Patient Phosphoproteomics receptor rescued SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2 spike protein secretion severe COVID-19 Signaling Spike protein T1D tested the SARS-CoV-2 TMPRSS2 Type 1 diabetes while [DOI] 10.1016/j.cmet.2021.05.013 PMC 바로가기 [Article Type] Article
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology
CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In VitroCAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화Immunology Published on 2021-07-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2 [DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology
CAR Macrophages for SARS-CoV-2 ImmunotherapyImmunology Published on 2021-07-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] CAR CD3ζ Cell-based therapy cellular phagocytosis chimeric antigen receptor coronavirus disease COVID-19 COVID19 cytosolic Defense domain domains Effects expression function high risk human macrophage hyperinflammation in vitro individuals with COVID-19 invading pathogens killing Macrophage macrophages MEGF10 MERTK Phagocytic activity Proinflammatory cytokine receptor reduced SARS-CoV-2 SARS-CoV-2 clearance Severe case severe cases Treatment unique upregulation virion [DOI] 10.3389/fimmu.2021.669103 PMC 바로가기 [Article Type] Immunology
Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19Pharmacology Published on 2021-07-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] anti-inflammatory effect can be used candidate caused China Comorbidities complications Compound country COVID-19 COVID-19 pandemic cumulative death deaths drug Effect effective experience glycyrrhizic acid glycyrrhizin human disease immune immune synergy immune system indicate inhibit killing macromolecular natural Patient patients with COVID-19 plant positive Protein reduce replication of SARS-CoV-2 Research SARS virus SARS-CoV-2 Stage steroid metabolism Structure synergy the epidemic the SARS-CoV-2 virus therapeutic drug Traditional Chinese medicine treat treating COVID-19 Treatment Vaccination strategy virus [DOI] 10.3389/fphar.2021.707205 PMC 바로가기 [Article Type] Pharmacology
The real seroprevalence of SARS-CoV-2 in France and its consequences for virus dynamics프랑스에서 SARS-COV-2의 실제 혈청 유병률과 바이러스 역학에 대한 결과Article Published on 2021-06-152022-09-01 Journal: Scientific Reports [Category] MERS, 진단, [키워드] assumed consequence effective epidemiological Epidemiology expected France geographical distribution killing lockdown parameter predict SARS-CoV-2 SARS-CoV-2 virus serological test Serological tests Seroprevalence Spread Statistical methods statistical model Symptom virus virus transmission [DOI] 10.1038/s41598-021-92131-0 PMC 바로가기 [Article Type] Article
To Trap a Pathogen: Neutrophil Extracellular Traps and Their Role in Mucosal Epithelial and Skin DiseasesReview Published on 2021-06-112022-10-31 Journal: Cells [Category] COVID-19, [키워드] cationic Cell circulating component composed COVID-19 cytokine secretion death degranulation disease DNA enzyme epithelia extracellular trap extracellular traps gonorrhea granular Health hydrolase immune defense in vitro in vivo Infection Inflammation Inflammatory bowel disease inflammatory disease inhibiting innate immune cell killing Local mechanism mucosal mucosal epithelium myeloperoxidase NET NETs neutrophil Neutrophil extracellular traps Neutrophils Pathogens peptides phagocytosis promote recruited Regulation role skin skin disease systemic inflammation systemic lupus erythematosus tissue damage [DOI] 10.3390/cells10061469 PMC 바로가기 [Article Type] Review
The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19Review Published on 2021-05-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activate aggregation cell damage chemokine circulation contributing to COVID-19 COVID-19 patients Endothelitis highlighting IL-8 immunothrombosis Infection Innate immunity killing mechanism mechanisms morbidity and mortality NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogenesis pathogenesis of COVID-19 Pathogens Platelet previous study promote prothrombotic regulated Research role SARS CoV-2 shown Thromboinflammation Thrombotic complications White blood cell [DOI] 10.3390/ijms22105368 PMC 바로가기 [Article Type] Review
Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatmentSARS-CoV-2에 대한 항체의 통합 개요와 COVID-19 예방 및 치료에 대한 가능한 응용Review Published on 2021-04-222022-09-12 Journal: Microbial Cell Factories [Category] MERS, SARS, 진단, [키워드] accelerated Activation antibodies antibody caused Cell characterization Clinical studies convalescent sera COVID-19 COVID-19 pandemic disease effective Efficacy expected humoral immune response immune response infecting killing mitigate nanobodies nanobody Neutralizing Other Viral Diseases pandemic disease producing Prophylactic Prophylaxis SARS-CoV-2 SARS-COV-2 infection Spread supplementary material synthesis the antibody therapeutic Treatment variety Viral diseases β-coronavirus [DOI] 10.1186/s12934-021-01576-5 PMC 바로가기 [Article Type] Review