Clinical outcomes of patients hospitalized for COVID-19 and evidence-based on the pharmacological management reduce mortality in a region of the Colombian CaribbeanObservational Study Published on 2021-06-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 임상, [키워드] Admitted Patient advanced age analyzed ARDS average carried Characteristics clinical Clinical management Colchicine Combination Comorbidities Comorbidity Complication Corticosteroid Corticosteroids COVID-19 COVID-19 drug treatment diagnosis of COVID-19 disease Emerging infectious disease evidenced Factor Health hospitalized patient implementation infections Kidney disease LMWH low molecular weight medication Mortality Mortality determinant mortality rate obesity outcome Patient patients hospitalized pharmacological management Public public health surveillance reduce reduce mortality reducing mortality regimen respiratory SARS-COV-2 infection Sepsis significant difference Sociodemographic characteristics the disease therapeutic Therapeutics Treatment Volume with COVID-19 [DOI] 10.1016/j.jiph.2021.02.013 PMC 바로가기 [Article Type] Observational Study
Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumoniaArticle Published on 2021-05-312022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] 95% CI Admission clinical trial Coagulopathy COVID-19 COVID-19 disease death dosage Effect evaluate evaluated female Hospital admission Interaction intubation IQR LMWH low molecular weight median age Mild Moderate COVID-19 PaO Patient patients with COVID-19 Pneumonia primary endpoint Probability progression Prophylactic receiving reduce Respiratory function risk Rome SARS-CoV-2 SARS-COV-2 infection significantly Stage therapeutic translate viral infection [DOI] 10.1038/s41598-021-90713-6 PMC 바로가기 [Article Type] Article
Anti–SARS-CoV-2 Natural Products as Potentially Therapeutic AgentsPharmacology Published on 2021-05-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 inhibitor agent Antiviral artificial candidate Cell Compound Coronavirus-2 COVID-19 drug effective host cells Influenza information inhibitor inhibitory compound investigated low molecular weight Membrane proteins mitigate molecular simulations natural natural products outbreak pandemic performed product recognize Replication replication inhibitor Respiratory disease SARS-CoV-2 SARS-COV-2 infection screened Specificities the disease treat virus virus entry virus entry blocker β-coronavirus [DOI] 10.3389/fphar.2021.590509 PMC 바로가기 [Article Type] Pharmacology
Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2SARS-CoV-2에 대한 항바이러스 펩티드의 활성에 대한 강력한 증거Opinion Published on 2021-05-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AMP AMPs anticancer antimicrobial peptide antimicrobial peptides antiparasitic Antiviral antiviral activities antiviral drugs antiviral peptides approved Bacteria caused clinical development clinical trial clinical trials coronavirus COVID-19 Defensins deficiency disease Ebola virus Efficacy Epidemic eukaryotic Evidence Evolution human cell human cells include insecticidal leads low molecular weight mechanism Multiple occurred optimization Organisms outbreak pandemic peptide peptide-based peptides produced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus specificity therapeutic Toxicity treat viral disease Viral diseases Zika virus [DOI] 10.3390/v13050912 PMC 바로가기 [Article Type] Opinion
Hypoxia may be a determinative factor in COVID-19 progressionShort communication Published on 2021-05-092022-10-05 Journal: Current Research in Pharmacology and Drug Discovery [Category] 신약개발, [키워드] affected amantadine anticoagulation treatment country Course COVID-19 COVID-19 early treatment COVID-19 mortality COVID-19 pathogenesis COVID-19 patients COVID-19 progression Critical D-dimer develop disease downstream drug Effect effective events example fluvoxamine Hospitalization host-directed therapy Hypothesis hypoxia indicated initiated Leukocytosis low molecular weight Low molecular weight heparins Mortality N-acetylcysteine observation predictor Prophylaxis repurposing SARS-COV-2 infection SARS-CoV-2 post-exposure prophylaxis SARS-CoV-2 virus infection sleep apnea the disease Treatment [DOI] 10.1016/j.crphar.2021.100030 [Article Type] Short communication
Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points말초혈액 microRNA와 COVID-19 환자: 방법론적 고려사항, 기술적 과제 및 실천 포인트Review Published on 2021-05-012022-09-11 Journal: RNA Biology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addressed among others Analysis angiotensin Angiotensin-converting enzyme ARDS Biomarker biopsies Blood circulating circulating miRNA profile circulating miRNA profiles Clinical practice coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 emergency COVID-19 patients detection Early detection experimental design heparin infection with SARS-CoV-2 Interpretation liquid biopsy LMWH low molecular weight low molecular weight heparin management methodological Methods microRNA MicroRNAs miRNA miRNA signature miRNAs ncRNA noncoding RNA pandemic peripheral public health qPCR reproducibility respiratory respiratory distress resulting rigour robust RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus transcriptomic translation variable [DOI] 10.1080/15476286.2021.1885188 PMC 바로가기 [Article Type] Review
Cellular Immune Response to COVID-19 and Potential Immune ModulatorsCOVID-19 및 잠재적 면역 조절제에 대한 세포 면역 반응Review Published on 2021-04-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Administered Anergy Antibiotics anticoagulation caused Cellular immune response characteristic characterized Clinical outcome Contact coronavirus Coronavirus disease 2019 COVID-19 Critical died Diseases droplet Factor Factors glucocorticoid heterogeneous Host Hyperactivation IFN immune immune response include Intravenous immunoglobulin LMWH low molecular weight Mild modulator no symptom outcome Patient patients Potential potential immune modulators previous study respiratory infectious disease response SARS-CoV-2 severe COVID-19 severity of COVID-19 the disease the patient therapy transmission of SARS-CoV-2 type I interferon viral infection virus [DOI] 10.3389/fimmu.2021.646333 PMC 바로가기 [Article Type] Review
Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential항고혈압 및 항-COVID-19 잠재성을 지닌 높은 용해도 및 내구성을 갖는 공동-비정질 발사르탄/니코틴아미드 조성물의 형성에서 수소 결합의 역할Article Published on 2021-04-012022-08-31 Journal: Molecular Pharmaceutics [Category] 치료제, [키워드] (nicotinamide) acting active pharmaceutical ingredient analyses angiotensin Angiotensin II anti-hypertensive applied approaches Bioavailability bond caused characterized co-amorphization conformational change conformational changes coronavirus COVID-19 Density functional theory Donor drug drugs Effects Efficacy exhibit flexible Formation functional heterodimeric hydrogen Hydrogen bond hydrogen bonds hypertension ingredient Interaction key factor liquid low molecular weight lung market molecules NIC nicotinamide pandemic coronavirus Physicochemical properties Potential quantum theory receptor receptor blocker responsible role SARS-COV-2 infection solid dispersion solubility treat valsartan X-ray [DOI] 10.1021/acs.molpharmaceut.0c01096 PMC 바로가기 [Article Type] Article
The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcomeCOVID-19 결과 예측에서 심장 손상, 염증 및 응고 사이의 관계Article Published on 2021-03-222022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] abnormality adverse outcome anticoagulation treatment association attenuate attenuation benefit change Coagulation Coagulopathy Complication confounders consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CRP D-dimer determinant Effect Endpoint enrolled greater heparin Hospitalized In-hospital individuals Inflammation Inflammatory Inflammatory response Injury low molecular weight low molecular weight heparin mechanism Mortality observational study outcome PaO pathway Pneumonia Predictive markers primary endpoint Prognostic markers risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia sensitivity severity single-center subject therapy Treatment troponin T [DOI] 10.1038/s41598-021-85646-z PMC 바로가기 [Article Type] Article
Self-injectable extended release formulation of Remdesivir (SelfExRem): A potential formulation alternative for COVID-19 treatment렘데시비르(SelfExRem)의 자가 주사 가능한 연장 방출 제형: COVID-19 치료를 위한 잠재적 제형 대안Article Published on 2021-03-152022-08-31 Journal: International journal of pharmaceutics [Category] MERS, SARS, 신약개발, 진단, 치료법, 치료제, [키워드] administer analyzed approach approval autoinjector benefit biodegradable polymer Care carried Concentration coronavirus Coronavirus 2019 COVID-19 COVID-19 patients COVID19 drug Drug administration effective evaluated face-to-face contact FDA food force Frequency globe Health Health care help Hospitalization In situ depot formulations indicated injection Intravenous injection Intravenous remdesivir Long-acting injectables low molecular weight mass vaccination pandemic Patient phosphate phosphate buffer PLGA Polymer provided RDV receiving reducing Remdesivir required Research SARS-CoV2 subcutaneous injection therapeutic Treatment treatment of COVID-19 tween vaccination w/v [DOI] 10.1016/j.ijpharm.2021.120329 PMC 바로가기 [Article Type] Article