molecules – Page 4 – Communicable Diseases Research

Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses

COVID-19 Pandemic 및 주요 인간 병원성 바이러스에 비추어 천연 소스 유래 황산화 다당류를 사용한 항 바이러스 전략

Review

Published on 2021-12-242022-09-10
Journal: Viruses [Category] SARS, 치료제,

SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis

SARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.

Research Article

Published on 2021-12-222022-09-10
Journal: Microbiology Spectrum [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 ACE2 expression Activation adverse effect adverse effects Affect alveolar alveolar epithelial cell Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Apoptosis Aspirin bind blunt bradykinin calcium Calcium signaling caspase cause caused Cell Cell signaling cells Coagulopathies complex Concentration contribute contributing to COVID-19 COVID-19 disease decreased expression downregulation dysfunction Effect Endothelial cell endothelial cells Endothelial dysfunction enzymatic activity enzyme epithelial epithelial cells event Evidence exposure expressed Factor homeostasis immunofluorescence microscopy in vitro model increased expression indicated infects Inflammation Interaction Interference Intervention Krüppel limit lung lung tissue lung tissues Lungs mechanism molecules organ dysfunction Pathogenesis pathology primary human cells pro-inflammatory molecules rationale receptor reduce reduced Respiratory function SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection Signaling significantly spike Spike protein suggested tested these cell These cells thought thrombotic Thrombotic events understanding uninfected Vascular viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article

Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets

코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적

Review

Published on 2021-12-092022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review

Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

SARS-CoV-2에 대한 천연 약물로서의 세파란틴 유사체 평가

Research Article

Published on 2021-12-092022-09-10
Journal: FEBS Open Bio [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition alkaloid analogue analogues binding affinities binding affinity Cepharanthine Compound conformation coronavirus coronavirus disease Coronavirus disease 2019 database demonstrated DIPHENYL disease docking drug Drug repurposing drugs Efficacy evaluate evaluated Evaluating humans Infection molecular docking molecules natural drug NPC1 performed predicted protease respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV Spike protein suggested target proteins tetrandrine the spike protein these compound these compounds were assessed
[DOI] 10.1002/2211-5463.13337 PMC 바로가기 [Article Type] Research Article

dockECR: Open consensus docking and ranking protocol for virtual screening of small molecules

dockECR: 소분자의 가상 스크리닝을 위한 개방형 합의 도킹 및 순위 지정 프로토콜

Article

Published on 2021-12-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] SARS, 치료기술, 치료제,

Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 Infection

SARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석

Meta-Analysis

Published on 2021-12-012022-08-31
Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘,

[키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score
[DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis

C-reactive protein as an effector molecule in Covid-19 pathogenesis

Covid-19 발병 기전에서 이펙터 분자로서의 C 반응성 단백질

Article

Published on 2021-11-012022-09-11
Journal: Reviews in Medical Virology [Category] SARS, 바이오마커, 임상,

[키워드] activate Affect affected Apoptosis article Asymptomatic C-reactive protein C-reactive protein (CRP caused clinical trials complement contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 immunity CRP CRP level CRP levels Cytokines damage database decrease died disease drug evaluated Evolution Factor immune system Immunity induce Inflammatory response inflammatory status involved molecules organ system organ systems outcome pandemic Pathogenesis Patient pro-inflammatory cytokine pro-inflammatory cytokines Randomized SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection severe evolution. systematic review the disease Treatment virus virus infection was performed
[DOI] 10.1002/rmv.2221 PMC 바로가기 [Article Type] Article

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

COVID-19에 대한 활동을 입증 한 승인 된 약물의 선택과 관련된 독성 위험의 계산 결정

Research

Published on 2021-10-212022-08-31
Journal: BMC Pharmacology & Toxicology [Category] 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach approved approved drug Cardiotoxicity caused clinical assessment clinical trial clinical trials Compound computational tool coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment demonstrated disease drug Drug discovery excretion expected facilitate FIVE global pandemic healthcare in silico independent knowledge majority manuscript metabolism molecules non-toxic off-label Patient pharmacological Practitioner predict profile receive repurposing Repurposing drugs, hERG) researcher respiratory Result risk safety profile SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe pneumonia significantly Spread Stratification supplementary material therapeutic therapeutic agent therapy Toxicity treating COVID-19 Treatment treatment for COVID-19 Usage Vaccine Vaccines
[DOI] 10.1186/s40360-021-00519-5 PMC 바로가기 [Article Type] Research

SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment

RNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수

Review

Published on 2021-10-132022-09-10
Journal: Immunity, Inflammation and Disease [Category] 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus
[DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

약물-유도인지 지질증은 SARS-CoV-2에 대한 약물 용도를 혼란스럽게한다

Article

Published on 2021-10-032022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 신약개발, 치료기술, 치료제,