mononuclear cell – Page 4 – Communicable Diseases Research

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients

Research

Published on 2022-07-132022-10-05
Journal: Cell Death Discovery [Category] 치료법,

Immunogenicity and Reactogenicity of Ad26.COV2.S in Korean Adults: A Prospective Cohort Study

한국 성인에서 Ad26.COV2.S의 면역원성과 반응성: 전향적 코호트 연구

Article

Published on 2022-07-112022-09-11
Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S Adenovirus Adenovirus Vector Adverse adverse event adverse events AEs anti-S IgG Anti-spike baseline cellular immunity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Delta Dilution enrolled enzyme enzyme-linked immunospot assay evaluated fatigue Fever followed by geometric mean geometric mean titers GMT GMTs GRADE Humoral immunity IgG antibody immunogenic immunogenicity injection site pain interferon interferon-γ Korean mononuclear cell MOST myalgia NAb titer Neutralizing Neutralizing activity neutralizing antibody responses omicron Omicron variant Omicron variants outcome pandemic participant Peripheral blood Prospective prospective cohort study resolved respiratory Safe SARS-CoV-2 serious AEs severe acute respiratory syndrome Coronavirus Single-dose South Korea T-cell immunity T-cell Response T-cell responses the median U/mL university hospital vaccination Vaccines variant variants Viral Viral variants waning immunity wild-type WT SARS-CoV-2
[DOI] 10.3346/jkms.2022.37.e210 PMC 바로가기 [Article Type] Article

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다

Article

Published on 2022-07-092022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19
[DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article

Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections

Delta SARS-CoV-2 감염이 있는 백신을 접종한 개인의 임상 특성 및 면역 프로필 변경

Article

Published on 2022-07-092022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, 치료기술,

[키워드] absorbance accelerated alteration Breakthrough infection breakthrough infections Characteristics clinical clinical recovery comparable Course cytokine Cytokine storms Delta delta variant facilitate groups Guangzhou Immune profile immunization Inactivated vaccine Inactivated Vaccines Inflammation Local median mononuclear cell observé outbreak PBMCs Peripheral blood Peripheral blood mononuclear cells Pneumonia protective effect Protective effects reduce reduced reported SARS-COV-2 infection significantly the disease transcription profile Transmission unique vaccinated individual vaccinated individuals vaccination Vaccine vaccine group Viral pneumonia viral RNA clearance viral titer VoC
[DOI] 10.1038/s41467-022-31693-7 PMC 바로가기 [Article Type] Article

Immune Responses Against SARS-CoV-2 WT and Delta Variant in Elderly BNT162b2 Vaccinees

노인 BNT162b2 백신의 SARS-CoV-2 WT 및 Delta 변이체에 대한 면역 반응

Article

Published on 2022-06-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] Against age Age-dependent immune responses after BNT162b2 analyzed antibody Antibody titer Antibody titers B.1.617.2 Blood BNT162b2 booster cellular cohorts coronavirus COVID-19 Delta delta variant elderly ELISPOT group groups highlighting humoral immune response IFNγ IgG titers immune response immune responses Immunoglobulin Immunoglobulin G mononuclear cell mononuclear cells neutralization ability neutralization activities neutralization activity neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies nursing homes overcome pandemic participant peripheral Peripheral blood Peripheral blood mononuclear cells resident response rising SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 WT second vaccination significantly increased specific antibodies Spike protein syndrome T cell T cell immunity T cell response vaccination vaccine dose vaccinee vaccinees Vaccines variants variants of concern variants of concern (VOCs) variants of SARS-CoV-2 Virus neutralization VOCs wild-type
[DOI] 10.3389/fimmu.2022.868361 PMC 바로가기 [Article Type] Article

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals

단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제,

[키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus
[DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article

Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes

Research article

Published on 2022-06-242022-10-05
Journal: Heliyon [Category] 바이오마커, 치료기술,

[키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed
[DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article

Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release in human peripheral blood mononuclear cells

Olverembatinib은 인간 말초 혈액 단핵 세포에서 SARS-CoV-2-Omicron 변이체 매개 사이토카인 방출을 억제합니다

Article

Published on 2022-06-082022-09-11
Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종,

SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity

SARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다

Article

Published on 2022-06-072022-09-12
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단,

Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysis

Research article

Published on 2022-06-022022-10-05
Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발,

[키워드] affected Analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 Therapeutic approach Transcriptome viral replication viral strain virus
[DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article