Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh방글라데시 SARS-CoV-2 게놈의 돌연변이 빈도의 시간적 풍경: 방글라데시에서 진행 중인 발병의 가능한 의미Article Published on 2021-10-012022-09-11 Journal: Virus Genes [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] age Analysis association Bangladesh change circulating condition conserved country COVID-19 D614G D614G mutation envelope envelope protein Evolution facilitate Factor Frequency function Genome GISAID Helicase implication intrinsic majority Model molecular phylogeny Mutation N protein nonspecific NSP11 NSP2 Nsp3 Nsp9 nucleocapsid protein ORF ORF3a ORF7b outbreak P323L performed platform Protein protein structure RdRP reference genome S2 domain SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 propagation SARS-CoV-2 strain selective sequenced Sex Spike protein strain susceptibility Temporal the Spike unique Vaccine development [DOI] 10.1007/s11262-021-01860-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19 Research Published on 2021-10-012022-10-05 Journal: Nature Immunology [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome Algorithms antibody Antibody binding assays children clinical disease control patient coronavirus correlated COVID-19 cytokine demonstrated disease severity epitope Frame fusion peptide heptad repeat Hospitalized Illness severity immune Infection Inflammatory MIS-C nucleocapsid ORF ORF3a ORF8 parameter pediatric prefusion prognostic Protein representing responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 protein SARS-CoV-2-neutralizing antibody serodiagnostic severe coronavirus disease severe COVID-19 syndrome targets Vaccine viral antibody Virus neutralization [DOI] 10.1038/s41590-021-01051-8 [Article Type] Research
Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In VitroResearch Article Published on 2021-09-282022-10-31 Journal: Disease Markers [Category] COVID-19, SARS, [키워드] A549 A549 cell acute respiratory syndrome caused CCL2 Cell chemokine chemotaxis component coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm demonstrated Effect exacerbate examined expression Frame function Genome IL-6 IL-8 Immune cell immunological change Infection infiltration local inflammation lung Lung inflammation monocyte Monocytes Neutrophils ORF pathogenesis of COVID-19 Pneumonia promote public health threat recruit recruitment reduced SARS-CoV-2 severe COVID-19 Specific specific effect suggested the SARS-CoV-2 virus tissue Type II pneumocyte [DOI] 10.1155/2021/6803510 PMC 바로가기 [Article Type] Research Article
Validation of GeneXpert testing for SARS-CoV-2 RNA in eight hospital laboratories in Oman오만의 8 개의 병원 실험실에서 SARS-COV-2 RNA에 대한 유전자 테스트 검증Comparative Study Published on 2021-09-012022-09-01 Journal: The Pan African Medical Journal [Category] SARS, 진단, 치료기술, [키워드] aims Cepheid comparison coronavirus country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cross-sectional cross-sectional study Ct values diagnostic diagnostic testing E gene eight evaluate highlight hospital Kingfisher Laboratory Liferiver molecular N gene Nasopharyngeal swab nasopharyngeal swabs National Oman ORF ORF gene Patient performed point of care presenting Public public health emergency Roche routine diagnostic testing RT-PCR RT-PCR kit RT-PCR kits SARS-CoV-2 SARS-CoV-2 RNA Sensitivity and specificity specimens Swab Testing TIB MOL BIOL validation Viral Viral load viral loads was tested was used [DOI] 10.11604/pamj.2021.40.2.27224 PMC 바로가기 [Article Type] Comparative Study
A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptomeSARS-CoV-2 트랜스라톰 및 트랜스크립톰의 고해상도 시간 지도Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused coronavirus COVID-19 deaths downstream enhancer evaluate function genomic help High-resolution human cells Human genome identify infecting initiate leader sequence mRNA ORF ORFs provide regulated Regulation respiratory resulting SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus sRNA subgenomic RNA subgenomic RNAs suppressor the SARS-CoV-2 Transcriptome translation translation initiation unique [DOI] 10.1038/s41467-021-25361-5 PMC 바로가기 [Article Type] Article
Revelation of Potent Epitopes Present in Unannotated ORF Antigens of SARS-CoV-2 for Epitope-Based Polyvalent Vaccine Design Using Immunoinformatics Approach면역정보학 접근법을 사용한 에피토프 기반 다가 백신 디자인을 위한 SARS-CoV-2의 주석이 없는 ORF 항원에 존재하는 강력한 에피토프의 계시Immunology Published on 2021-08-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 신약개발, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis antigen expression antigenic B-cell B-cell epitope B-cell epitopes canonical Canonical protein epitopes carried CD4+ T-cell CD8+ T-cell conformational coronavirus Coverage eight epitope epitope-based polyvalent vaccine Epitopes expressed FIVE followed by highest HLA I supergroups immunodominant immunogenic kill linear linear B-cell epitope linear B-cell epitopes linkers Mutation mutations N-protein Open reading frame open reading frames ORF ORF3c ORF7a Orf9b overlap Polyvalent potent present Protein Region regions respiratory revelation SARS-CoV-2 scenario severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein T-cell T-cell epitope T-cell epitopes the spike protein uORFs Vaccine variant variants [DOI] 10.3389/fimmu.2021.692937 PMC 바로가기 [Article Type] Immunology
A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse ModelArticle Published on 2021-08-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 5′ UTR Antigen antigenic C-terminus Cell Cell-mediated immunity chimeric cytoplasmic demonstrated domain elicited exhibited expressed expressing Frame gene encoding hosts humoral immune response immunized increasingly infected cell Influenza Influenza virus inoculated MDCK cell Model mouse mucosal Neutralizing activity ORF passages peptide-based platform potent prime-boost regimen producing Protein Pseudotyped virus RBD response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine sera Seven single-cycle influenza virus-based vaccine spike RBD spike-pseudotyped virus the RBD the SARS-CoV-2 the vaccine Vaccine Vaccine development variants virus [DOI] 10.3390/vaccines9080850 PMC 바로가기 [Article Type] Article
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinResearch article Published on 2021-08-012022-10-05 Journal: Vaccine: X [Category] 치료제, [키워드] Anti-viral anti-viral antibody antibody Antibody Response antigen-specific T cell Antiviral approach auxiliary B cell repertoire Cell characterized components convalescent COVID-19 patient convalescent patient convalescent plasma COVID-19 COVID-19 convalescent patient COVID-19 patient demonstrated effective expected full-length full-length protein humoral identify Immunoglobulin majority membrane memory B memory B cell monoclonal antibody nucleocapsid ORF performed produced Protein Proteins Pseudovirus neutralization assay RBD reveal S protein SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection Somatic hypermutation specific antibody spike the antibody the receptor-binding domain the Spike the spike protein Viral proteins [DOI] 10.1016/j.jvacx.2021.100098 [Article Type] Research article
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses코로나바이러스의 오픈 리딩 프레임(ORF)에서 게놈 순서와 관련성을 체계화Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Accessory Accessory genes accessory protein accessory proteins agent analyzed Cluster complex conserved Coronaviridae coronavirus coronavirus disease coronavirus disease-2019 CoV CoVs effort ENCODE envelope focus Frame gene clusters Genes Genome genomes genomic genus greater mechanisms membrane naming nucleocapsid Open reading frame ORF ORF gene ORF3a ORF3b ORF3c ORF3d ORF5 ORFs pandemic Phylogeny polypeptide Protein Proteins Referral RNA genome RNA genome. RNA virus RNA viruses SARS-CoV-2 structural proteins the Spike transcriptional translational viral genome [DOI] 10.1016/j.meegid.2021.104858 PMC 바로가기 [Article Type] Article
SARS-CoV-2: from its discovery to genome structure, transcription, and replicationReview Published on 2021-07-192022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] abundance ACE2 acute respiratory syndrome Atypical cleaved complex conducted contagious coronavirus COVID-19 COVID-19 pandemic Efficiency ENCODE exhibit expressing full-length function Genetic Genome genome structure genomic RNA gRNA infected cell infected cells Interaction isolates motif mRNA non-structural protein Nsp12 nsp13 Nsp9 ORF ORF1a ORF1b Pneumonia polyprotein positive-sense protease Proteins Replication respiratory virus responsible RNA RNA primer RNA synthesis RTC SARS-CoV-2 SARS-CoV-2 genome sgRNA sgRNAs single-stranded subgenomic RNA susceptible cell synthesis the SARS-CoV-2 genome TMPRSS2 Transcription transcription regulatory sequence translate translation TRS upstream Vesicle viral genome viral genome replication viral replication [DOI] 10.1186/s13578-021-00643-z PMC 바로가기 [Article Type] Review