Rapid behavioural response of urban birds to COVID-19 lockdownCOVID-19 잠금에 대한 도시 조류의 신속한 행동 대응Ecology Published on 2021-03-102022-09-10 Journal: Proceedings of the Royal Society B: Biological Sci [Category] SARS, 치료기술, [키워드] activities adjust animals baseline baseline data behavioural behavioural plasticity Biodiversity birds citizen science collected conditions coronavirus disease country COVID-19 COVID-19 pandemic detectability Early Morning Effect environmental conditions growth Hypothesis increase in involved less lockdown measure mechanism natural environments Occurrence plasticity Probability provide Rapid reduction Spain unique urban areas Urban ecology [DOI] 10.1098/rspb.2020.2513 PMC 바로가기 [Article Type] Ecology
Clinical and molecular aspects of veterinary coronavirusesReview Published on 2021-03-082022-11-01 Journal: Virus research [Category] COVID-19, 조류인플루엔자, [키워드] Characteristics clinical Clinical sign Clinical signs coronavirus Coronavirus infection Coronaviruses Cross-species transmission diagnosed disease Diseases event highly pathogenic Host Human infect knowledge Middle East Modification molecular molecular basis Mutation New coronavirus one health ORFs Pathogenesis plasticity Prevent promote public health receptor Recombination Replication respiratory RNA virus SARS-CoV-2 spreads turn veterinary medicine [DOI] 10.1016/j.virusres.2021.198382 PMC 바로가기 [Article Type] Review
Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexesResearch Article Published on 2021-03-032022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome amino acid changes Cluster complementary complex complexes coronavirus enzyme exhibiting hallmark humans infect non-structural protein Nsps pandemic pathway plasticity protein concentrations regulate replication-transcription complex residue RTC SARS-CoV-2 Seven three groups topologies Topology zoonotic coronaviruses [DOI] 10.1126/sciadv.abf1004 PMC 바로가기 [Article Type] Research Article
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans스파이크 단백질과 인간 ACE2 간의 결합 능력 예측의 역학은 인간에서 SARS-CoV-2의 적응 전략을 보여줍니다Article Published on 2021-02-042022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Amino acid Analysis analyzed binding ability binding affinity collected Computational biology and bioinformatics conserved coronavirus country COVID-19 pandemic Dynamics Ethnic groups genome sequence hACE2 Host hosts Human human ACE2 Interaction Mutation natural reservoir Novel coronavirus Phylogenetic analysis Phylogeny plasticity RBD Receptor-binding domain recombination event reconstructed Region respiratory reveal S gene SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stability the receptor-binding domain the spike protein Transmission variant variants viral infection [DOI] 10.1038/s41598-021-82938-2 PMC 바로가기 [Article Type] Article
High-resolution mining of the SARS-CoV-2 main protease conformational space: supercomputer-driven unsupervised adaptive sampling †Chemistry Published on 2021-02-022022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] adaptive appear approach C-terminal Clustering analysis conformational Critical distal Drug discovery exhibit Focusing GPU High-resolution highlight histidine inactive less M pro marker mimicking modulating molecular molecular interaction monomer observé performed physiological plasticity producing protease reducing residue residues Result selective shown stability statistical the SARS-CoV-2 trajectory Volume was performed water molecule [DOI] 10.1039/d1sc00145k PMC 바로가기 [Article Type] Chemistry
Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain31 Published on 2021-01-072022-10-28 Journal: Pain Reports [Category] COVID-19, [키워드] acute phase angiotensin-converting enzyme 2 cause Cell cellular entry changes in COVID-19 COVID-19 disease cytokine profile direct infection ENhance Evidence expected Factors Impact implication induce infect Interaction late stage moderate nervous system Neurobiology neurological Neuropathy neuropilin 1 Nociceptor Novel coronavirus NRP1 NRP2 Pain plasticity potential mechanism promote protease receptor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Stage Symptom the disease the SARS-CoV-2 the spike protein unique viral entry virus [DOI] 10.1097/PR9.0000000000000885 PMC 바로가기 [Article Type] 31
Mouse Ifit1b is a cap1-RNA–binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1cImmunology Published on 2020-12-182022-10-30 Journal: The Journal of Biological Chemistry [Category] Coronavirus, [키워드] antiviral activity bind binding cells cofactor competing complex coronavirus Coronavirus infection facilitate higher eukaryotes Host host cell Human human infection IFIT1 IFIT3 Infection inhibit Innate immunity interferon-induced protein interferon-induced proteins with tetratricopeptide repeats (IFIT) Interpretation knockout lack Methylation mice Modification modulate mouse mouse model mRNA murine nucleotide orthologue plasticity Protein regulated restrict RNA RNA-binding protein rodents similarity stimulatory translation translation control viral immunology virus yielding [DOI] 10.1074/jbc.RA120.014695 PMC 바로가기 [Article Type] Immunology
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesSARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection [DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across speciesResearch article Published on 2020-12-012022-10-05 Journal: Neurobiology of Learning and Memory [Category] 비임상, [키워드] Abstract addition ADHD Alter anti-inflammatory action Attention benefit Brain cognitive cortical deficit dendritic Effect Evidence executive expand explain function functions Guanfacine inhibit Injury Intuniv mechanism of action memory Mental disorder Mental Disorders microglia modulation neuronal NMDAR Norepinephrine off-label plasticity Potassium reducing Research Schizophrenia selective Signaling Stress stress-related disorder synaptic therapeutic action translation translational variety Working memory α2A-adrenoceptor [DOI] 10.1016/j.nlm.2020.107327 [Article Type] Research article
Bovine Coronavirus: Variability, Evolution, and Dispersal Patterns of a No Longer Neglected BetacoronavirusArticle Published on 2020-11-102022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] affecting approach bovine Bovine coronavirus clinical impact Cluster compensatory mutation Complete complex contrary coronavirus disease European Evidence evidenced Evolution favor Genome Host International Migration Mutation Neglected Occurrence other coronaviruses pathogen pattern phylodynamic phylodynamics phylogeography plasticity preventive measure Protein recombination rate reduce Respiratory disease Selection selective spike gene Spike protein Strains the United State tissue tropism vaccination Variability viral evolution viral genome viral tropism while [DOI] 10.3390/v12111285 PMC 바로가기 [Article Type] Article