pro-inflammatory cytokine – Page 4 – Communicable Diseases Research

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역

Article

Published on 2022-07-012022-09-11
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단,

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research

K18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점

Review

Published on 2022-06-282022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development
[DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review

The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection

세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다

Review

Published on 2022-06-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제,

[키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked
[DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review

Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation

Research

Published on 2022-06-222022-10-05
Journal: Acta pharmacologica Sinica [Category] 바이오마커,

[키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4
[DOI] 10.1038/s41401-022-00933-3 [Article Type] Research

D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir

D,L-리신-아세틸살리실레이트 + 글리신(LASAG)은 SARS-CoV-2 복제를 감소시키고 렘데시비르와 함께 추가 효과를 나타냅니다

Article

Published on 2022-06-212022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] Acetylsalicylic acid acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Additive additive effect adverse effect adverse effects Antiviral approach approved Aspirin cell culture system chip model Coagulation factors Combination complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cytokines disease Effect Efficacy expression glycine Healthcare system Healthcare systems in vitro inhibitory effect investigated L-lysine LASAG medication medications other diseases Patient pro-inflammation pro-inflammatory cytokine pro-inflammatory cytokines Remdesivir repurposing salt SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus show Therapeutic strategies therapeutic strategy these compound these compounds Vaccine viral infection while
[DOI] 10.3390/ijms23136880 PMC 바로가기 [Article Type] Article

Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion

IFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨

Article

Published on 2022-06-112022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus
[DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article

Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options

SARS-CoV-2 회피의 특성화: 인터페론 경로 및 치료 옵션

Review

Published on 2022-06-082022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antagonism Antiviral antiviral therapy characterization characterized circumvent contribute Control Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patients Critical critical state drug dysregulated Efficacy evade explain expression Factor helping host innate immunity IFN IFN response IFN signaling pathway IFN-III IFNs in some individual Infection inhibit innate immune innate immune response Innate immunity interferon interferon-stimulated gene ISG mechanism new SARS-CoV-2 option pathogenicity Pathways pro-inflammatory cytokine responsible robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the disease therapy treat Vaccines variant virus virus–host interactions
[DOI] 10.3390/v14061247 PMC 바로가기 [Article Type] Review

Influence of exercise and vitamin D on the immune system against Covid-19: an integrative review of current literature

Covid-19에 대한 면역 체계에 대한 운동과 비타민 D의 영향: 현재 문헌의 통합 검토

Review

Published on 2022-06-012022-09-11
Journal: Molecular and cellular biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome coronavirus addition affected age anti-inflammatory cytokine anti-inflammatory cytokines association caused chronic disease Chronic diseases Concentration contribute coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines Defense defense mechanism environmental factors Factor genetics Health Organization health system Hypovitaminosis D IL-10 IL-1β IL-4 IL-6 immune response immune system increase in Infection infections Infectious disease Infectious diseases influence maintenance mechanism microorganisms morbidity morbidity and mortality New coronavirus nutritional status pandemic Patient physical physical activity Physical exercise Physical status pro-inflammatory cytokine pro-inflammatory cytokines reduction in Regular respiratory respiratory infections responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly the cytokine storm the disease therapy TNF-α triggering viral infections virus Vitamin D vitamin D level vitamin D levels WHO World Health Organization
[DOI] 10.1007/s11010-022-04402-7 PMC 바로가기 [Article Type] Review

Potential plants for inflammatory dysfunction in the SARS-CoV-2 infection

SARS-CoV-2 감염에서 염증 기능 장애에 대한 잠재적 식물

Review

Published on 2022-06-012022-09-11
Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects antioxidant appear cardiovascular risk characterized clinical trial clinical trials CRP Cytokines described disease dysfunction Effects Efficacy evaluate form homeostasis IFN-γ IL-1 IL-6 Infection Inflammation Inflammatory Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory process marker mechanism modulation organism oxidative plant plants Potential pro-inflammatory cytokine responsible SARS-CoV-2 SARS-COV-2 infection selected significantly increased systematic review the SARS-CoV-2 therapeutic effects TNF-a
[DOI] 10.1007/s10787-022-00981-5 PMC 바로가기 [Article Type] Review

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

SARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다

Article

Published on 2022-05-192022-09-11
Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses
[DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article