Upping the ante on mammalian antiviral RNA interference포유류의 항바이러스 RNA 간섭에 대한 항의Article Published on 2021-09-082022-09-11 Journal: Cell Host & Microbe [Category] Coronavirus, Fulltext, SARS, 유전자 메커니즘, [키워드] Antiviral Defense implication knowledge mammal mammalian mammals mechanism RNA interference SARS-CoV-2 Science suppress Therapeutic strategies viruses Zika virus [DOI] 10.1016/j.chom.2021.08.006 PMC 바로가기 [Article Type] Article
Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2Article Published on 2021-09-012022-10-06 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 진단, [키워드] adopted Algorithm characterization complementary complex COVID-19 effective Efficacy feature gene silencing Genome guide RNA Health Human genome humans Infection Molecular docking study molecular dynamics mRNA Neutralizing outbreak outcome parameter parameters pathway Post-transcriptional gene silencing Prevent Proteins RdRP RdRp gene replication-transcription complex RNA RNA interference RNA-dependent RNA polymerase SARS-CoV-2 selected shown siRNA siRNA molecule siRNA molecules siRNAs Small interfering RNA Spread stability target target protein the SARS-CoV-2 therapeutic therapy viral infection [DOI] 10.1016/j.meegid.2021.104951 PMC 바로가기 [Article Type] Article
Strategies to Inhibit Hepatitis B Virus at the Transcript LevelReview Published on 2021-07-092023-06-02 Journal: Viruses [Category] B형 간염, [키워드] Chronic Hepatitis B covalently closed circular DNA nuclear receptor RNA interference transcription factor transcriptional inhibitor Viral integration [DOI] 10.3390/v13071327 PMC 바로가기 [Article Type] Review
Long and short non-coding RNA and radiation response: a reviewReview article Published on 2021-07-012022-10-05 Journal: Translational research : the journal of laboratory [Category] 비임상, [키워드] alteration anti-sense oligonucleotides arising ASOanti-sense oligonucleotides binding biofluids Biomarker CADcoronary artery disease Cancer Cell cellular processe cellular stress response changes in circRNAcircular RNA circular RNA Coronary artery disease DCAdicentric chromosome assay diabete diagnostic dicentric chromosome assay disease Disease progression DNA Effect EMTepithelial-to-mesenchymal transition epithelial-to-mesenchymal transition evaluate examined expression level expression profile form Future gray (unit) Gygray (unit) interactions introduced invasive ionizing radiation IRionizing radiation lncRNA lncRNAlong noncoding RNA Long long noncoding RNA Messenger RNA microRNA miRNA miRNAmicroRNA modulate modulation mRNA mRNAMessenger RNA mRNAs ncRNA ncRNAnoncoding RNA ncRNAs non-coding RNA Non-small cell lung cancer noncoding RNA NSCLCnon-small cell lung cancer oxidative stress PBMCperipheral blood mononuclear cells Peripheral blood mononuclear cells piRNApiwi-interacting RNA piwi-interacting RNA prognostic biomarker Proteins Radiation radiation exposure Radiotherapy reactive oxygen species regulate reported Research RNA RNA expression RNA interference RNAiRNA interference ROSreactive oxygen species serum short hairpin RNA shown shRNAshort hairpin RNA siRNAsmall interfering RNA Small interfering RNA small nuclear RNA small nucleolar RNA snoRNAsmall nucleolar RNA snRNAsmall nuclear RNA stability Stress TBItotal body irradiation therapeutic use thought total body irradiation transfer RNA tRNAtransfer RNA untranslated region UTRuntranslated region [DOI] 10.1016/j.trsl.2021.02.005 [Article Type] Review article
Plasmids Expressing shRNAs Specific to the Nucleocapsid Gene Inhibit the Replication of Porcine Deltacoronavirus In VivoArticle Published on 2021-04-232023-08-29 Journal: Animals : an Open Access Journal from MDPI [Category] E형 간염, [키워드] nucleocapsid Porcine deltacoronavirus RNA interference short hairpin RNA [DOI] 10.3390/ani11051216 PMC 바로가기 [Article Type] Article
MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreakReview Published on 2021-04-222022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory distress antiviral immune response candidate clinical status COVID-19 COVID-19 complication COVID-19 outbreak COVID-19 therapy ENhance Exosome Exosomes Gene therapy Immune suppression immunomodulatory involved lung management Mesenchymal stem cells miRNA MSCs pandemic Pathogenesis platform Prevent regenerative regimen RNA RNA interference SARS-CoV-2 SARS-CoV-2 pathogenesis siRNA syndrome target targets the SARS-CoV-2 therapeutic therapeutic option therapeutic strategy therapy Treatment viral spread Virus life cycle [DOI] 10.1186/s12967-021-02840-3 PMC 바로가기 [Article Type] Review
Genome-Wide Transcriptional Analysis and Functional Validation Linked a Cluster of Epsilon Glutathione S-Transferases with Insecticide Resistance in the Major Malaria Vector Anopheles funestus across Africa유전체 전반에 걸친 전사 분석 및 기능 검증을 통해 아프리카의 주요 말라리아 매개체인 Anopheles funestus에서 곤충 저항성과 관련된 엡실론 글루타티온 S-전이효소 클러스터가 연결되었다.Article Published on 2021-04-132024-08-08 Journal: Genes [Category] 말라리아, [키워드] Anopheles funestus glutathioneS-transferase malaria Metabolic resistance RNA interference [DOI] 10.3390/genes12040561 PMC 바로가기 [Article Type] Article
DisCoVering potential candidates of RNAi-based therapy for COVID-19 using computational methodsBioinformatics Published on 2021-02-262022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis bat candidate comprehensive analysis computational approach computational method conducted conserved COVID-19 down-regulate experimental validation facilitate FIVE high affinity humans implementation independent International Intervention material miRNA miRNA-mRNA interaction Novel coronavirus pandemic Region RNA RNA interference RNA intervention-based therapy SARS-CoV-2 Side effect Side effects siRNA siRNA design suggested the SARS-CoV-2 genome therapy therapy for COVID-19 time-consuming Treatment viral infections Virology [DOI] 10.7717/peerj.10505 PMC 바로가기 [Article Type] Bioinformatics
The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses InfectionPharmacology Published on 2021-02-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome anticancer antioxidant antiviral activity cause China clinical complication Compound coronavirus Coronavirus infection coughing death determine drugs Effect expression Fever Genes Genetic immune system include Infection inhibiting Interference miRNA miRNAs Morphological natural natural products organ pandemic phytochemicals Pneumonia Potential product Replication reported respiratory infection review RNA RNA interference SARS-CoV-2 SARS-CoV-2 virus Shortness of breath shown siRNA siRNAs virus Wuhan [DOI] 10.3389/fphar.2021.616993 PMC 바로가기 [Article Type] Pharmacology
A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2SARS-CoV-2의 뉴클레오캡시드 인단백질 및 표면 당단백질 유전자를 억제하기 위한 전향적 도구로서 잠재적인 siRNA 분자를 설계하기 위한 컴퓨터 접근 방식Article Published on 2021-01-012022-08-31 Journal: Genomics [Category] MERS, SARS, 신약개발, 치료법, [키워드] absence Antiviral treatment approach best binding caused complementary COVID-19 develop Efficacy free energy GC content Genes genome replication globe glycoprotein host cell hybridization magnitude melting temperature molecular docking analysis mRNA neutralization nucleocapsid Nucleocapsid phosphoprotein outbreak pandemic pathway power predicted Protein public health RNA interference RNA virus RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence siDirect siRNA siRNA molecule siRNA molecules siRNAs Small interfering RNA specific target gene specific target genes surface Surface glycoprotein Target genes temperature Treatment Viral viral gene expression viral infection viral infections virus was collected [DOI] 10.1016/j.ygeno.2020.12.021 PMC 바로가기 [Article Type] Article