Two-tiered SARS-CoV-2 seroconversion screening in the Netherlands and stability of nucleocapsid, spike protein domain 1 and neutralizing antibodies네덜란드의 2단계 SARS-CoV-2 혈청전환 스크리닝 및 뉴클레오캡시드, 스파이크 단백질 도메인 1 및 중화항체의 안정성Article Published on 2021-07-012022-09-11 Journal: Infectious diseases (London, England) [Category] SARS, 진단, 치료법, [키워드] an area antibody applied approach Asymptomatic individuals Cluster complement COVID-19 pandemic declined domain ELISA Follow-up had no highlight IgG IgG ELISA incidence individual individuals Infection information initial lateral flow lateral flow assay Longevity longitudinal majority molecular Netherland neutralization test Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid nucleocapsid protein plateau positive proportion reporting symptom RT-PCR testing S1 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Seroconversion Serological testing serology serology testing specificity Spike protein stability Support surrogate virus neutralization test sVNT Symptom symptomatic and asymptomatic titre titres virus neutralization test was performed with COVID-19 [DOI] 10.1080/23744235.2021.1893378 PMC 바로가기 [Article Type] Article
Early Humoral Responses of Hemodialysis Patients after COVID-19 Vaccination with BNT162b2BNT162b2로 COVID-19 백신 접종 후 혈액 투석 환자의 초기 체액 반응Article Published on 2021-07-012022-09-11 Journal: Clinical journal of the American Society of Nephro [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses BNT162b2 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop dialysis exceeded first dose greater healthy control healthy controls Hemodialysis high risk humoral Humoral response IgG Infection interquartile range majority median mRNA vaccine neutralization Neutralizing antibodies neutralizing antibody nine Participants Patient positive receiving Receptor binding reduced respiratory response S1 domain SARS-CoV-2 SARS-CoV2 second dose sensitivity severe coronavirus disease single-center study Spike protein the spike protein threshold university vaccination Vaccine vaccine dose Viral viral neutralization [DOI] 10.2215/CJN.03700321 PMC 바로가기 [Article Type] Article
Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South AfricaResearch Article Published on 2021-06-232022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] African Algorithm Antigen assays collected COVID Diagnosis diagnostic ELISA enzyme-linked immunosorbent Euroimmun evaluate IgA IgG IgG antibody individual infected individual management negative controls PCR performance positive reported respiratory S1 domain Sample SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection semi-quantitative sensitivity serum and plasma South South Africa specificity Spike protein stratified symptomatic individual Symptoms syndrome tested the SARS-CoV-2 timepoint Transmission [DOI] 10.1371/journal.pone.0252317 PMC 바로가기 [Article Type] Research Article
V483A: an emerging mutation hotspot of SARS-CoV-2Review Published on 2021-06-222022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Abstract binding affinity Factor high transmission hotspot hydrophobicity Infectivity information Interaction monoclonal antibodies mutant mutant virus Mutation North America occurred occurrence rate S1 domain SARS-CoV-2 Spike protein stability Substitution mutation the spike protein the vaccine Transmissibility V483A Vaccine viral genome virus virus–host cell interaction wild-type [DOI] 10.2217/fvl-2020-0384 PMC 바로가기 [Article Type] Review
Longitudinal detection of SARS‐CoV‐2‐specific antibody responses with different serological methods다양한 혈청학적 방법을 통한 SARS-CoV-2 특이 항체 반응의 종단적 검출Comparative Study Published on 2021-06-112022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibodies antibody Antibody Response Antigen antigens assays Blood donors cells children collected Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 detect diagnostic eight ELISA ELISAs healthy blood donors highest IgA IgG IgM immunofluorescence Immunoglobulin immunoglobulin A Immunoglobulin G immunoglobulin M immunosorbent indirect immunofluorescence individual infections information Kinetics longitudinal Patient peaked polymerase chain polymerase chain reaction Prevalence Protein provided respiratory S1 domain SARS‐CoV‐2 SARS‐CoV‐2‐infected SARS‐CoV‐2 seasonal coronaviruses selected sensitivities sensitivity sera serological serological assays Serological testing serology serum sample serum samples specific antibodies specific antibody specificity Spike protein substrate symptom onset tested the viral nucleocapsid Viral viral nucleocapsid protein virus [DOI] 10.1002/jmv.27113 PMC 바로가기 [Article Type] Comparative Study
Characterization of Winter Dysentery Bovine Coronavirus Isolated from Cattle in Israel이스라엘에서 소에서 분리된 겨울 이질 소 코로나바이러스의 특성화Brief Report Published on 2021-06-042022-10-28 Journal: Viruses [Category] Coronavirus, MERS, 세균성이질, [키워드] amplify Analysis Bovine coronavirus cattle characterization characterized circulating collected coronavirus diarrhea dysentery Genetic variant hemagglutinin esterase Hemorrhagic Isolated knowledge Local molecular analysis molecular data positive reduction in S glycoprotein S1 S1 domain sequence spike strain Strains were used Winter winter dysentery [DOI] 10.3390/v13061070 PMC 바로가기 [Article Type] Brief Report
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2동반 질환은 SARS-CoV-2에 대한 적응 면역 반응의 변화와 관련이 있습니다.Research Article Published on 2021-03-222022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료법, [키워드] Adaptive immune response Adaptive immunity age Analysis antibody Antibody Response Antibody responses Beta cells breadth CD4 Clinical outcome Cohort Comorbidities convalescent COVID-19 death diabetes envelope protein envelope proteins Ethnicity flow cytometry function functional functions Hospitalization Hospitalized illness illnesses immune system immunology magnitude nucleocapsid obesity reduced risk factor S1 domain SARS-CoV-2 serology severe COVID-19 Sex subject subjects symptom onset T cell T cells These data [DOI] 10.1172/jci.insight.146242 PMC 바로가기 [Article Type] Research Article
An Overview of Spike Surface Glycoprotein in Severe Acute Respiratory Syndrome–CoronavirusMolecular Biosciences Published on 2021-03-162022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] antiviral drug binding China cleaved contagious Corona coronavirus CoV COVID-19 disease drug design ENCODE entry inhibitors envelope protein enzyme Genetic Genome highest Host host cell host cell receptor include inhibit inhibitor initial involved membrane protein MERS monomer mortality rate non-structural protein non-structural proteins Novel coronavirus nucleocapsid protein predominant protease researcher respiratory S1 and S2 S1 domain S1/S2 S2 domain SARS-CoV-2 shown small molecule spike spike (S) glycoprotein structural protein structural proteins subunit surface Surface glycoprotein target the S protein the WHO therapeutic treat Treatment Vaccine viral genome viral infection viral infections virulent virus [DOI] 10.3389/fmolb.2021.637550 PMC 바로가기 [Article Type] Molecular Biosciences
Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection경도 SARS-CoV-2 감염에 대한 항체 반응의 이질성 및 혈청 역전의 시계열 분석 및 기계론적 모델링Research Paper Published on 2021-03-022022-09-11 Journal: EBioMedicine [Category] SARS, 진단, 치료법, [키워드] Analysis Anti-S1 antibody antibody levels antibody production Antibody Response antibody titres assays Asymptomatic Blood blood sampling changes in clearance Comparisons correlated deaths evaluate Extended faster finding Follow-up funding greater healthcare worker heterogeneity heterogeneous Humoral immunity identify IgG Infection infections London Longevity Longitudinal studies longitudinal study Mathematical modelling mechanism median Mild mild infection mild SARS-CoV-2 infection neutralising antibody titre NIHR participant PCR peak population level positive production rate prospective cohort study protective humoral immunity pseudovirus pseudovirus neutralizing antibody recruited reduction in reductions in required response Roche S1 domain SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection SARS-CoV-2, Serology, Mathematical modelling, Sero-reversion semi-quantitative serological analysis serological response serology sustained Symptom time transition Viral viral nucleocapsid protein viral spike was performed Wellcome Trust [DOI] 10.1016/j.ebiom.2021.103259 PMC 바로가기 [Article Type] Research Paper
Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan일본의 무증상 코로나19 환자에서 중화항체를 포함한 불완전한 체액 반응Article Published on 2021-03-012022-09-11 Journal: Virology [Category] SARS, 진단, 치료법, [키워드] acquisition antibodies antibody Asymptomatic asymptomatic to mild clinical Clinical features controls correlated COVID-19 COVID-19 patient CRP D-dimer disease disease severity domain enrolled examined Extracellular humoral Humoral immunity immune response Incomplete Japan lymphopenia Mild mild COVID-19 patients mild patient mild patients MOST N protein neutralization titer neutralization titers neutralizing antibody Neutralizing assay Neutralizing titer neutralizing titers pandemic of COVID-19 patients with asymptomatic PCR test Pneumonia procalcitonin Receptor-binding domain reported S1 domain SARS-CoV-2 serological test serum antibodies serum antibody spike spike-ACE2 Symptom Virus neutralization [DOI] 10.1016/j.virol.2020.12.020 PMC 바로가기 [Article Type] Article