Analytical and Clinical Evaluation of the Semiquantitative Elecsys Anti-SARS-CoV-2 Spike Protein Receptor Binding Domain Antibody Assay on the Roche cobas e602 AnalyzerRoche cobas e602 분석기에서 반정량적 Elecsys Anti-SARS-CoV-2 스파이크 단백질 수용체 결합 도메인 항체 분석의 분석 및 임상 평가Article Published on 2022-01-062022-09-11 Journal: American journal of clinical pathology [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analyzer Anti-spike anti-spike antibodies antibodies antibody Bilirubin Biotin clinical clinically Concordance coronavirus COVID-19 COVID-19 patient COVID-19 vaccination cross-reactivity detect diagnostics Elecsy ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluate evaluated exhibit greater hemoglobin IgA antibodies IgA antibody IgG IgM immunoassay Interference Lateral flow device linearity measure mRNA Neutralization assay PCR positivity plasma Precision Protein Receptor binding domain respiratory robust Roche SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus Semiquantitative semiquantitatively Sensitivity and specificity serology Seropositivity serum spike Spike protein triglycerides turn [DOI] 10.1093/ajcp/aqab092 PMC 바로가기 [Article Type] Article
Prevalence and duration of detectable SARS-CoV-2 nucleocapsid antibodies in staff and residents of long-term care facilities over the first year of the pandemic (VIVALDI study): prospective cohort study in EnglandArticle Published on 2022-01-012022-11-15 Journal: The Lancet. Healthy longevity [Category] SARS, 진단, 치료기술, [키워드] Abbott Analysis antibody blood sample boost Care cumulative Department detectable Endpoint England Follow-up identify IgG antibody immunoassay incidence incidence rate Infection IQR Kaplan-Meier curves Long-term care median median time Mortality National Health Service natural infection nucleocapsid Older pandemic participant Prevalence proportion prospective cohort study Protein reported risk SAR-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid stability survived tested the antibody response undetectable unique vaccine responses were infected women [DOI] 10.1016/S2666-7568(21)00282-8 PMC 바로가기
Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 체액 및 T 세포 반응Article Published on 2022-01-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, 치료기술, [키워드] Absolute lymphocyte count adaptive Adaptive Biotechnology age analyzed anti-CD20 therapy Anti-SARS-CoV-2 S antibodies antibody Antibody Response B and T-cell BMI CD19 characterized chemotherapeutic agents cohort study comparator conducted coronavirus coronavirus vaccine COVID COVID-19 COVID-19 epidemic Descriptive statistics detectable determine did not produce Efficacy Elecsy Eligible patients enrolled Enrollment evaluate Fisher Fisher's exact test had no humoral Humoral response IgG immune response immunoassay immunogenicity Immunoglobulin Immunoglobulin G immunosuppressive impair Infection likelihood lymphocyte Multiple multiple sclerosis Natalizumab negative antibody response no correlation Ocrelizumab Patient patients patients treated positive positive antibody response post vaccination Prevent producing question raise reduce Research response Roche SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination severity Sex shown single center T-cell T-cell Response T-cell responses Test the antibody response treated Treatment vaccination Vaccine vaccine immunogenicity variable was performed were excluded Wilcoxon rank sum [DOI] 10.1016/j.msard.2021.103382 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 Delta Variant Case Manifesting as Extensive Placental Infection and Fetal TransmissionArticle Published on 2022-01-012022-11-15 Journal: Gynecologic and obstetric investigation [Category] SARS, 변종, 치료기술, [키워드] analyzed Apoptosis B.1.167.2 Cell COVID-19 Delta delta variant determine dominant exhibited Extensive Ferroptosis fetal fixed higher infectivity Infection membrane membranes mother Mutation Necrosis Placenta placental Placental infection placental tissue positive Pregnancy Premature Probability receptor-binding motif rupture SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection Spike protein tested Transmission umbilical variant Vascular endothelium vertical transmission Viral RNA with COVID-19 [DOI] 10.1159/000524905 PMC 바로가기
Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus중증 급성 호흡기 증후군 코로나바이러스 2 및 에볼라 바이러스에 대한 렘데시비르의 지방 아실 접합체의 합성 및 항바이러스 활성Article Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] A significant reduction acute respiratory syndrome antiviral activities antiviral activity antiviral agent Antiviral agents Calu3 CaLu3 cells characterization comparable Compound conjugate Conjugates coronavirus derivative derivatives Ebola Ebola virus EBOV Effectiveness exhibited fatty Fatty acid fatty acids Fatty acyl-RDV conjugates half-life Human plasma IMPROVE in viral in vitro less mono physical purification RDV reduction in remained Remdesivir Replication RNA synthesis SAR SAR-CoV-2 SARS-CoV-2 selected shown Structure-activity relationships (SAR). synthesis these compound these compounds Transcription VeroE6 cells Viral RNA viral RNA synthesis [DOI] 10.1016/j.ejmech.2021.113862 PMC 바로가기 [Article Type] Article
Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients성인 입원 환자에서 인플루엔자 A (H1N1) 및 SARS-COV-2에 대한 단일 및 이중 감염의 임상 및 바이러스 학적 영향Research Article Published on 2021-11-292022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단, 치료기술, [키워드] Acute heart failure Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus Admission admittance Adult patients adults hospitalized adverse event adverse events affected All participant All participants All the patient all the patients ARDS Bacterial infections baseline both virus both viruses caused China clinical Clinical outcome Clinical severity clinical status Clinical symptoms Co-infection Coinfection Comprehensive coronavirus COVID-19 pandemic Ct value Ct values demographic described diagnosis of COVID-19 diagnostics electronic medical record electronic medical records enrolled Epidemic Frequency future therapeutic groups Guangdong Guangzhou H1N1 H1N1 infection heart failure Hospitalization Hospitalized ICU incidence Infection Influenza influenza A initial Inpatient Inpatients laboratory data Lower mechanism median medical records molecular nasopharyngeal swabs Older age Ordinal Scale Patient patients patients hospitalized PCR cycle positively correlated Prevalence prevalence rate Prophylactic respiratory SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection score Seasonal influenza Secondary bacterial infections seven-category ordinal scale severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significantly Symptom tested threshold trajectory Transmission Treatment Viral Viral load Viral RNA viral RNA detection Virological virus viruses were assessed with COVID-19 [DOI] 10.1371/journal.pntd.0009997 PMC 바로가기 [Article Type] Research Article
Pregnancy as a Risk Factor of Severe COVID-19Review Published on 2021-11-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome age Asymptomatic caused change changes in claimed coronavirus coronavirus disease 19 Course COVID-19 COVID-19 mortality death Effect Epidemics etiological agent Factor global pandemic healthcare higher risk highlight ICU admission mechanical ventilation MERS-CoV morbidities other coronaviruses outcome pandemic pathophysiology physiological Pregnancy pregnant women Prophylaxis SAR-CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 Infection subcellular Symptoms synergistic the SARS-CoV-2 Treatment understanding Vaccine with COVID-19 women [DOI] 10.3390/jcm10225458 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021SARS-CoV-2 변이체 및 관련 돌연변이 프로필: 2021년 여름 업데이트Research Article Published on 2021-11-172022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals antigenicity antivirals assist caused circulating variant circulating variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnostic domains Efficacy emerging variants event Evolution full-length Genetic GISAID highlighting Human human-to-human transmission impacts mapped modulate monoclonal antibodies Mutation mutations Nextstrain pandemic profile Protein provide reported respiratory retrieved SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus spike mutation spike mutations Spike protein Stanford summer the SARS-CoV-2 the spike protein Therapeutics three-dimensional structure Vaccine variant variants variants of concern Viral viral infectivity VOCs VOIs website [DOI] 10.1128/Spectrum.01096-21 PMC 바로가기 [Article Type] Research Article
The effectiveness of various gargle formulations and salt water against SARS-CoV-2SARS-COV-2에 대한 다양한 양치용 제제 및 바닷물의 효과Article Published on 2021-10-152022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] addition Asymptomatic asymptomatic patient asymptomatic patients BSA calculated chlorhexidine chloride condition conditions COVID-19 Culture cytotoxicity disease disease spread effective Effectiveness eliminating erythrocytes European evaluated Formulation gargle Gargling hexetidine inactivation Incubation period infected patient infected patients infectious dose kill log Medical research Microbiology preventive measure preventive measures protocol reducing reduction in risk of transmission salt SAR-CoV-2 SARS-CoV-2 Spearman-Karber Spread Standard tested the disease Thymol tissue tissue culture titre titres Transmissibility Transmission Treatment Vero E6 VERO E6 cells Viral virucidal virus virus titer virus titre Virus titres virus transmission water [DOI] 10.1038/s41598-021-99866-w PMC 바로가기 [Article Type] Article
Cytidine deamination-induced perpetual immunity to SAR-CoV-2 infection is a potential new therapeutic targetSAR-CoV-2 감염에 대한 시티딘 탈아미노화 유도 영구 면역은 잠재적인 새로운 치료 표적입니다Review Published on 2021-10-152022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, SARS, 변종, [키워드] antibody Asymptomatic cause causes cell types contributing to COVID 19 COVID-19 cytidine Cytidine deaminase develop focus generate Human immune cell type immune cell types immune response immune responses immune system Immunity Infection initiate long-lasting molecular New variants of Coronavirus Perpetual immunity provided reason Research responses SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 virus SRS-CoV-2 Survivors symptomatic people the SARS-CoV-2 virus therapeutic target vaccination Variation variations viral strains virus [DOI] 10.7150/ijms.61779 PMC 바로가기 [Article Type] Review