serine 2 – Page 4 – Communicable Diseases Research

Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function

Reviews

Published on 2021-11-262022-10-05
Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 변종,

Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19

Research

Published on 2021-11-122022-10-29
Journal: JAMA Network Open [Category] COVID-19, MERS,

[키워드] 30-Day mortality 95% CI adjusted Administered age Analysis analyzed androgen association baseline body mass index Cancer center clinical trial cohort study collected Comorbidity Cooperative COVID-19 COVID-19 diagnosis COVID-19 infection decrease decreased mortality defined Deprivation diabetes diagnosis of cancer Evidence exposure expression finding Follow-up group Importance Infection Initially Kidney disease maintain measure median age men metastatic disease Mortality mortality rate neoplasm no significant difference objective Older Orchiectomy participant Patient patient data patients patients with COVID-19 performance status Point primary end point Primary outcome propensity score matching Prostate Prostate cancer protease receive receiving recorded reducing Relevance Result SARS-COV-2 infection serine 2 setting severity smoking status statistically significant difference Support the SARS-CoV-2 therapy TMPRSS2 transmembrane treated Treatment university was performed were excluded white with COVID-19 women
[DOI] 10.1001/jamanetworkopen.2021.34330 PMC 바로가기 [Article Type] Research

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells

저산소증은 hCMEC/D3 뇌 내피 세포에서 ACE2 및 TMPRSS2 SARS-CoV-2 세포 진입 매개체의 발현을 변경합니다

Article

Published on 2021-11-012022-09-11
Journal: Microvascular research [Category] SARS, 유전자 메커니즘,

[키워드] accompanied ACE2 ACE2 mRNA acute respiratory syndrome coronavirus Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) blood-brain barrier Blood-brain barrier (BBB) Blot Brain Cell cell entry changes in Control control group coronavirus 2 COVID19 decrease Effect endothelial Endothelial cell endothelial cell damage endothelial cells enzyme expression expression of SARS-CoV-2 Factor followed by groups Human Human brain Human cerebral microvascular endothelial cells (hCMEC/D3) hypoxia hypoxic hypoxic condition identify IL-6 in vitro induce interleukin interleukin 6 marker mechanism mRNA Neurological complication Neurological complications oxygen pro-inflammatory cytokine protease Protein protein expression qPCR receptor reduced regulate replicated respiratory SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent susceptibility TMPRSS2 TMPRSS2 expression TMPRSS2 protein transmembrane transmembrane protease serine 2 transmembrane protease serine 2 (TMPRSS2) von Willebrand factor western blot
[DOI] 10.1016/j.mvr.2021.104232 PMC 바로가기 [Article Type] Article

Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and Mortaparib Plus

Mortaparib 및 Mortaparib Plus의 항 -CovID-19 전위에 대한 계산 및 시험 관내 실험 분석

Biophysics

Published on 2021-10-292022-09-10
Journal: Bioscience Reports [Category] MERS, SARS, 신약개발, 치료제,

[키워드] ACE2 activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral assays antiviral drug attenuate bind cancer biology candidate Candidates catalytic caused Cell cell surface receptor Compound computational analysis Computational biology coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose down-regulate down-regulation dual expression health emergency host cell host cell surface host cells identify implicated in vitro independent Infection inhibitor inhibitory activity M pro measure mechanisms Mortaparib non-toxic pandemic PARP predicted protease Protein receptor Replication respiratory SARS-CoV-2 SARS-CoV-2 main protease screened Serine serine 2 severe acute respiratory syndrome Coronavirus Small molecules TMPRSS2 transmembrane protease serine 2 treated Vaccine Viral virus
[DOI] 10.1042/BSR20212156 PMC 바로가기 [Article Type] Biophysics

Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction

Article

Published on 2021-10-292022-10-04
Journal: Communications Medicine [Category] 치료기술,

[키워드] ACE2 angiotensin-converting enzyme 2 caused Cell cell types cellular cofactor confocal microscopy Coronavirus disease 2019 COVID-19 COVID-19 patient demonstrated Direct disease Dizziness dysfunction Express expression hearing loss in vitro in vitro model infect Infection infection rate Infectious disease molecular molecular mechanism novel coronavirus SARS-CoV-2 Organoid organoids pandemic patients with COVID-19 pluripotent stem cells precursor problem protease receptor required Result SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2 virus Schwann cell serine 2 stem cells susceptible Symptom Symptoms target these symptoms tissue tissues TMPRSS2 transmembrane two-dimensional underlie vascular disease Virology virus entry with COVID-19
[DOI] 10.1038/s43856-021-00044-w PMC 바로가기 [Article Type] Article

Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2

Research Article

Published on 2021-10-192022-10-27
Journal: BioMed Research International [Category] COVID-19, MERS,

Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2

인간 막 횡단 프로테아제 세린 2 (TMPRSS2) 및 SARS-COV-2에서의 미스 센스 변이체의 계산 분석

Research Article

Published on 2021-10-192022-09-10
Journal: BioMed Research International [Category] 변종,

[키워드] 3D structure activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect deleterious effects Effect evaluated facilitate Human identify missense variant mutant posttranslational modification PROCHECK progression Prostate cancer protease Protein proteolytic cleavage PROVEAN PTMs Ramachandran plot respiratory S protein SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus SIFT stability susceptibility target cell target cells Template tested the S protein TMPRSS2 transmembrane variant Viral viral entry
[DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition

인간 심근세포의 고효율 SARS-CoV-2 감염: 스파이크 단백질 매개 세포 융합 및 억제

Virus-Cell Interactions

Published on 2021-10-062022-09-10
Journal: Journal of Virology [Category] MERS, SARS, 변종,

[키워드] 2019 aberrant host response accounted ACE2 Activation activity Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Autopsy block canonical cardiac cardiac complication Cardiac complications cardiac damage cardiac tropism cardiovascular complication cardiovascular complications catalytic site Cell Cell fusion cell lines cell surface cell-cell fusion cells cleavage cleavage site coding coronavirus coronavirus disease correlated COVID-19 COVID-19 patient cytopathic Cytopathic effect cytoplasm cytoplasmic tail direct infection disrupt Drug discovery efficient examined exceeded Express expressed expression vector fluorescent furin furin cleavage motif furin-like protease furin-like proteases fused fusing fusion fusion inhibition green fluorescent protein Human human cardiomyocyte in vitro model inactive Infection inhibition Lungs mechanism monomeric mRNA mutant Mutation Myocardium occur other coronavirus other coronaviruses parental Particle patients peptide-based platform pluripotent stem cell-derived cardiomyocytes protease Protein protein cleavage Proteolytic processing receptor replicate required respiratory respiratory infection SARS-CoV-2 SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus spike Spike protein Spread structures Syncytia systemic inflammation the spike protein These data thrombosis tissue TMPRSS2 Transformed cell transmembrane transmembrane protease serine 2 tropism of SARS-CoV-2 Vesicle Viral viral replication viral transcript viral transcription viral transcripts Virus-like particle virus-like particles viruses
[DOI] 10.1128/JVI.01368-21 PMC 바로가기 [Article Type] Virus-Cell Interactions

Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues

비만 및 케톤 생성 식단은 쥐의 폐와 심장 조직에서 SARS-CoV-2 진입 단백질 ACE2 및 TMPRSS2와 레닌-안지오텐신 시스템을 뚜렷하게 조절합니다

Article

Published on 2021-09-252022-09-10
Journal: Nutrients [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] ACE2 Affect Alter angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-inflammatory effect attenuate components diet elevated enzyme Gene Expression heart hearts IL6 increase individuals Inflammation inflammatory gene inflammatory genes interleukin-6 interleukin-6 receptor ketogenic Ketogenic diet Ketogenic Diets ketones lung lung tissues Lungs MasR mechanism Migration obese obesity obesogenic outcomes protease Protein RAS RAT Renin renin-angiotensin system SARS-CoV-2 SARS-CoV-2 entry Serine serine 2 severity Severity of infection sucrose System tested the SARS-CoV-2 tissues TLR4 TMPRSS2 TMPRSS2 level TMPRSS2 levels TNF-alpha Toll-like receptor toll-like receptor 4 transmembrane transmembrane protease serine 2 Viral viral entry were measured
[DOI] 10.3390/nu13103357 PMC 바로가기 [Article Type] Article

Human genetic basis of coronavirus disease 2019

2019년 코로나바이러스 질병의 인간 유전적 기초

Review

Published on 2021-09-202022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ABO ACE ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen base Blood Blood Group Blood groups caused Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 incidence disease Ethnic groups explain genders Genetic genetic diversity genetic factors genetic findings Genotype genotypes groups help heterogeneous HLA Host genetic factor Human human leukocyte antigen Infectious diseases leukocyte Medical genetics morbidity and mortality mortality rate mortality rates multifactorial Novel coronavirus outcome Pathogenesis populations Predictive markers protease respiratory SARS-CoV-2 SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus severity susceptibility targeted therapy TMPRSS2 transmembrane variant variants Viral
[DOI] 10.1038/s41392-021-00736-8 PMC 바로가기 [Article Type] Review