Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing구조 기반 약물 설계를 사용한 SARS-CoV-2 스파이크 당단백질에 대한 선택된 천연 파이토케미컬의 항바이러스 효능Article Published on 2022-04-082022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis binding binding affinity Bioavailability candidate Compound conducted Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 crystal structure database disease distribution docked docked complex docked complexes drug drug candidate drug targets Effectiveness Environment excretion flavonoid Health host cells Immunological response library metabolism milk molecular molecular docking molecular dynamic simulation molecular interaction MPD3 natural pandemic PDB penetrate pharmacological target Phylloflavan phytochemical phytochemicals Protein PubChem Receptor binding domain S-RBD SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Sickness silico studies silico study spike spike glycoprotein Spike protein subgroups thistle Virtual screening virulent was obtained Zinc [DOI] 10.3390/molecules27082401 PMC 바로가기 [Article Type] Article
ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patientsObservational Study Published on 2022-04-022022-10-05 Journal: BMC Anesthesiology [Category] 임상, [키워드] ABO ABO blood group acute respiratory distress addition adjusted Admission Adult patient age and sex analysed analyses Antigen assessment association Blood Blood Group Blood group antigen cells circulation Cohort COVID-19 cohort Critical care Critically ill critically ill patients days alive demonstrated diagnose disease eligible Epidemiology erythrocytes failure FIVE for inclusion groups ICUs inotrope intensive care intensive care unit invasive ventilation morbidity morbidity and mortality Mortality multicentre multivariable regression model multivariable regression models no difference no significant difference observation outcome Patient patient population previous study Region RhD blood group. Scania sensitivity analysis Sepsis Septic shock subgroup subgroups subgroups of patient Support syndrome trauma unique Vasopressor Ventilation [DOI] 10.1186/s12871-022-01626-4 PMC 바로가기 [Article Type] Observational Study
Anxiety and depression in patients with advanced cancer during the COVID-19 pandemicCOVID-19 전염병 동안 진행된 암 환자의 불안과 우울증Multicenter Study Published on 2022-04-012022-09-11 Journal: Supportive Care in Cancer [Category] COVID19(2023년), SARS, 치료기술, [키워드] Advanced cancer age Anxiety association Cancer Cancer patients cancer type children clinical variables Cohort consecutive patient COVID-19 COVID-19 pandemic Depression diagnosed Diagnosis distress early diagnosis Effect emotional distress Factor female greater higher risk histology Hope hopelessness Hopelessness. illness incidence increased risk index initiated Intervention inventory linear regression analyses Linear regression analysis marital status multicenter no differences pandemic Patient Psychological psychological factors regression analysis scale Sociodemographic Stage subgroups survival Treatment Uncertainty women Worry [DOI] 10.1007/s00520-021-06789-3 PMC 바로가기 [Article Type] Multicenter Study
Risk for Reinfection After SARS-CoV-2: A Living, Rapid Review for American College of Physicians Practice Points on the Role of the Antibody Response in Conferring Immunity Following SARS-CoV-2 InfectionSARS-CoV-2 후 재감염 위험: SARS-CoV-2 감염 후 면역을 부여하는 데 있어 항체 반응의 역할에 대한 미국 의과대학 실습 요점을 위한 살아있는 신속한 검토Review Published on 2022-04-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Alpha variant Asymptomatic Care Clinical practice college database Delta diagnose eligible Evidence General population Health care Health care worker health care workers Health Organization Immunity Immunocompromised index case individual individuals Infection infection risk infection with SARS-CoV-2 investigator Longitudinal studies longitudinal study Meta-analysis omicron OVID Patient physician Point Practice prevented PROSPERO protection public health Quality Racial ranged Rapid reduced risk Reinfection remained response Result review risk risk difference role SARS-CoV-2 SARS-COV-2 infection strength subgroups symptomatic symptomatic infection symptomatic infections uninfected variant variants wild-type World Health Organization [DOI] 10.7326/M21-4245 PMC 바로가기 [Article Type] Review
The path towards herd immunity: Predicting COVID-19 vaccination uptake through results from a stated choice study across six continents집단 면역을 향한 경로: 6개 대륙에 걸친 명시적 선택 연구의 결과를 통해 COVID-19 예방 접종 섭취 예측Article Published on 2022-04-012022-09-11 Journal: Social science & medicine (1982) [Category] 변종, [키워드] Characteristics circulating variant circulating variants collected country COVID-19 COVID-19 vaccination COVID-19 vaccines Efficacy herd immunity higher risk highlight Immunity increase increase in individual infectiousness Obtaining offer offered predict question reduced severity Side effect Side effects simple subgroups Support the vaccine uptake vaccination Vaccine variant [DOI] 10.1016/j.socscimed.2022.114800 PMC 바로가기 [Article Type] Article
Ivermectin for the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-analysis of Randomized Controlled Trials코로나바이러스 질병 2019 치료를 위한 이버멕틴: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-03-232022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 임상, [키워드] 95% confidence interval Adult patients adverse event adverse events AEs all-cause mortality all-cause mortality rate all-cause mortality rates benefit Bia confidence interval Control control group control groups Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity did not reduce Effect evaluated Evidence Hospital stay inverse Ivermectin LOS main analyses mean difference meta-analyses Meta-analysis Mild moderate Mortality mortality rates outcome outcomes Patient patients with COVID-19 performed Placebo Primary outcomes random effect Randomized controlled trial Randomized controlled trials RCT RCTs reduced Relative risk review risk risk of bia RoB SAE SAEs SARS-CoV-2 searched secondary Secondary outcomes severe AE severe AEs severity of COVID-19 Standard of care subgroups treat viral clearance [DOI] 10.1093/cid/ciab591 PMC 바로가기 [Article Type] Meta-Analysis
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)코로나19 이후 증후군 및 만성 피로 증후군(ME/CFS) 환자의 내피 기능 장애 및 변경된 내피 바이오마커Article Published on 2022-03-222022-09-11 Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 age analysed angiopoietin angiotensin Angiotensin-converting enzyme association Biomarker Biomarkers blood pressure BMI chronic fatigue syndrome clinical parameter Clinical parameters cohort of patient Concentration criteria defined Diagnostic Criteria dysfunction elevated Encephalomyelitis endocan endothelial endothelial cells Endothelial dysfunction endothelial function Endotheliitis Endothelin Endothelin-1 Endothelium ET-1 Evidence exhibited fatigue fatigue syndrome FIVE HCs healthy control hyperaemia IL-8 infect investigated malaise Myalgic encephalomyelitis/chronic fatigue syndrome paradoxical Pathomechanism Patient patients peripheral positive correlation post-COVID syndrome profile reactive Reactive hyperaemia index. SARS-CoV-2 seronegative serum Sex shown significantly subgroups subset Symptom syndrome [DOI] 10.1186/s12967-022-03346-2 PMC 바로가기 [Article Type] Article
The impact of COVID-19 on income and employment and willingness to become vaccinated among African Americans enrolled in a smoking cessation randomized trialRandomized Controlled Trial Published on 2022-03-152022-10-04 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] African African American African Americans approach clinical trial coronavirus COVID COVID-19 COVID-19 vaccine development demonstrated employment enrolled finding Health highlight impacted IMPROVE Intensive MOST Population randomized trial smoker smoking subgroups the vaccine Vaccine Vaccine acceptance Vaccine hesitancy vaccine-hesitant with COVID-19 [DOI] 10.1016/j.vaccine.2022.01.064 PMC 바로가기 [Article Type] Randomized Controlled Trial
Reduced levels of pulmonary surfactant in COVID-19 ARDSArticle Published on 2022-03-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] adult COVID-19 patients ARDS Biomarkers Bronchoalveolar lavage fluid clinical trial collected COVID-19 COVID-19 patient COVID-19 patients DPPC healthy control healthy controls infrared intubation less Medical research Pathogenesis Patient patient group principal component analysis Spectroscopy subgroups [DOI] 10.1038/s41598-022-07944-4 PMC 바로가기 [Article Type] Article
Changing Social Mentality among University Students in the COVID-19 Pandemic: A Five-Wave Longitudinal Study in ChinaArticle Published on 2022-03-052022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Administered ANOVA association changed changes in Changing China covariate covariates COVID-19 COVID-19 pandemic evaluate female FIVE Gender group groups Intervention longitudinal longitudinal study lowest mental health Mentality nuclear online questionnaires P -value pandemic parents peaked positive post-hoc analysis Research significantly social mentality Structure student subgroups suggested university university students variables was used Wave were used [DOI] 10.3390/ijerph19053049 PMC 바로가기 [Article Type] Article