supernatant – Page 4 – Communicable Diseases Research

Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses

Article

Published on 2021-09-172022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Virus-induced senescence is a driver and therapeutic target in COVID-19

Research

Published on 2021-09-132022-10-05
Journal: Nature [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, 치료제,

[키워드] accompanied activation of platelet affected airway cascade cells cellular senescence Clinical severity Combination complement COVID-19 cytokine demonstrated eliminated endothelial cells endothelial damage Escalation Factor Factors feature form hallmark Immune cell infected cells Inflammation lung Lung disease Macrophage macrophage activation marker mice mucosa Neutrophil extracellular trap neutrophil infiltration organ damage pathogenic phenotype pro-inflammatory cytokines quercetin reduced SARS-CoV-2 SARS-CoV-2-infected hamster SASP secretion Serum level Stress supernatant therapeutic target thrombosis Treatment viral infections virus-infected cell viruses widespread with COVID-19
[DOI] 10.1038/s41586-021-03995-1 [Article Type] Research

Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2

중증 급성 호흡기 증후군 코로나바이러스 2에 의한 기간 태반 감염에 대한 임상 및 시험관 내 증거

Clinical Trial

Published on 2021-09-012022-09-11
Journal: The American journal of pathology [Category] SARS, 유전자 메커니즘, 임상, 치료기술,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell clinical consequence coronavirus coronavirus 2 coronavirus disease Defense demise during pregnancy enzyme expression fetus Host immunohistochemistry In situ hybridization Infection mechanism membrane mother Newborn not express Placenta Placental infection Placentas positive control Pregnancy Pregnancy confirmed protease Protein quantification question raise receptor Replication respiratory reverse transcriptase reverse transcriptase PCR SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virions Serine serine 2 severe acute respiratory syndrome Coronavirus supernatant syncytium term TMPRSS2 transmembrane transmembrane protease serine 2 Transmission undetectable Vero E6 vertical transmission virus
[DOI] 10.1016/j.ajpath.2021.05.009 PMC 바로가기 [Article Type] Clinical Trial

Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2

Article

Published on 2021-08-262022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

장기간 COVID-19/PASC(Post-Acute Sequelae of COVID-19)의 지속적인 응고 단백질 병리는 항플라스민 수치 증가를 동반합니다

Original Investigation

Published on 2021-08-232022-09-10
Journal: Cardiovascular Diabetology [Category] MERS, SARS, 진단, 치료기술,

[키워드] accompanied acute COVID-19 acute infection acute respiratory syndrome acute respiratory syndrome coronavirus amyloid A Antiplasmin Anxiety benefit blood clot Blood clots breath characterized circulating clinical pathologies clotting Coagulopathies Coagulopathy Control control sample coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 phenotype Depression diabetes digested fatigue Fibrin(ogen) fibrinogen fibrinolysis fibrinolytic system fluorescence microscopy healthy individuals Hypercoagulation increase in individual Infection Inflammatory inhibit Long Long COVID/PASC Microclots muscle weakness oxygen oxygen exchange PASC Pathologies pathology Patient pellet persistent plasma plasma sample plasma samples platelet hyperactivation Protein proteomics regime respiratory Result SAA serum amyloid A severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 supernatant Support survivor Symptom Symptoms syndrome therapy Type Type 2 diabetes mellitus Volume weakness
[DOI] 10.1186/s12933-021-01359-7 PMC 바로가기 [Article Type] Original Investigation

Identification of SARS-CoV-2 entry inhibitors among already approved drugs

이미 승인 된 약물 중 SARS-COV-2 진입 억제제의 확인

Article

Published on 2021-08-012022-08-31
Journal: Acta pharmacologica Sinica [Category] SARS, 신약개발, 치료제,

[키워드] Amiodarone antagonist approved approved drug approved drug library approved drugs azelastine bosutinib clemastine clinical investigation clinically COVID-19 COVID-19 treatment drug drug library effective drug effective drugs Entry inhibitor flupenthixol high throughput screening assay Histamine histamine receptor histamine receptor antagonists identification in vivo inhibited inhibitor inhibitors molecular Pseudotyped virus pseudovirus entry receptor reducing Replication SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virus SARS2 screened significantly supernatant toremifene Treatment trimeprazine Vero E6 Vero E6 cell VERO E6 cells Viral viral RNA load virus entry virus entry inhibitors.
[DOI] 10.1038/s41401-020-00556-6 PMC 바로가기 [Article Type] Article

First surveillance of SARS-CoV-2 and organic tracers in community wastewater during post lockdown in Chennai, South India: Methods, occurrence and concurrence

인도 남부 첸나이에서 폐쇄 후 지역 사회 폐수에서 SARS-CoV-2 및 유기물 추적자의 첫 번째 감시: 방법, 발생 및 동시성

Article

Published on 2021-07-152022-09-11
Journal: The Science of the total environment [Category] SARS, 치료기술,

[키워드] absence biochemical biochemical oxygen demand caffeine can be used Chain Reaction Chemical Chemical marker Chennai Clinical data collected Combination Community Concentration conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infected patients cycle cycle threshold dynamic range Efficiency enveloped virus Epidemiology filtration FIVE followed by hospital Indicator infected individual lockdown Occurrence oxygen oxygen demand pandemic plant polymerase chain reaction predicted proportion qRT-PCR Quantitative removal responsible RNA RNA copies SARS-CoV-2 sediment Sewage treatment Sludge solid phase South south India SPS SPSS study period supernatant Surveillance tendency threshold time interval Treatment Viral load virus wastewater wastewater based epidemiology
[DOI] 10.1016/j.scitotenv.2021.146252 PMC 바로가기 [Article Type] Article

Identification of Human SARS-CoV-2 Monoclonal Antibodies from Convalescent Patients Using EBV Immortalization

Article

Published on 2021-07-052022-10-27
Journal: Antibodies [Category] COVID-19,

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

Original Contribution

Published on 2021-07-052022-10-28
Journal: Basic Research in Cardiology [Category] COVID-19, Fulltext,

[키워드] ACE2 angiotensin-converting enzyme 2 B.1.1.7 B.1.351 caused Cell cellular distribution clearance Coronavirus disease 2019 COVID-19 direct infection double-stranded EDEM1 Effect Effects elevated endothelial Endothelial cell endothelial cells Endothelial dysfunction ER stress expressed Health higher risk highest Human in vitro Increased induce Infection Infectious virus Inflammation inoculated lung marker misfolded protein Mortality novel coronavirus SARS-CoV-2 P.2 Patient pro-inflammatory promote receptor reduced required responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant significantly higher Spike protein supernatant supplementary material susceptibility susceptible tested the SARS-CoV-2 the spike protein umbilical variant vascular bed Viral RNA viral spike protein virus infection virus replication Virus trapping wild type
[DOI] 10.1007/s00395-021-00882-8 PMC 바로가기 [Article Type] Original Contribution

Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings

실험실 환경에서 SARS-CoV-2의 안정성 및 비활성화 방법 평가

Original Investigation

Published on 2021-07-012022-09-12
Journal: Medical Microbiology and Immunology [Category] MERS, SARS, 진단,

[키워드] acetone acute respiratory disease addition Analysis analyzed Bio safety biosafety level Biosafety Level 3 BSL-3 Caco-2 causative agent Cell culture Corona virus COVID-19 Crystal violet Culture culture media denaturation dose effective Ethanol evaluated guanidine handling heat inactivation inactivation infected cell infected cells Infection Laboratory level 3 lysate lysates lysed lysis buffer media methanol Microscopy molecular Molecular biology Novel coronavirus novel coronavirus SARS-CoV-2 PFA Proteins removal required Research RT-qPCR SARS-CoV-2 Spread stability staining subsequent supernatant supplementary material susceptible TCID tested tissue tissue culture Vero Cell Vero cells viral sample virus
[DOI] 10.1007/s00430-021-00716-3 PMC 바로가기 [Article Type] Original Investigation