Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect인간 게놈 다양성 데이터는 L564P가 우세한 TPC2 변이체이며 M484L 기능 획득 효과와 관련된 금발 머리의 전제 조건임을 보여줍니다Research Article Published on 2021-01-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affected Analysis analyzed association Bacterial infections bacterial toxin bacterial toxins Cancer cancer cell Cancer cells cation channel changes in characterized cholera toxin cholesterol data set database Degradation described diabete diabetes disease Diseases distribution drug target Ebola Ebola virus Effect example functional gain-of-function Genome Genome-wide association studies Genome-wide association study geographical distribution glucagon hair color Human human disease Human genome human population human populations implicated Infectious disease Infectious diseases investigated isoform likelihood melanin Meta-analysis metabolic disease mice nucleotide obesity overlapping Parkinson’s disease pathophysiological pharmacological physiological pigmentation defect pigmentation defects polymorphism Polymorphisms populations predominant Protein provide reduced resulting secretion Single nucleotide polymorphism single nucleotide polymorphisms systematic analysis traits Treatment variant Variation variations virus viruses was performed were assessed [DOI] 10.1371/journal.pgen.1009236 PMC 바로가기 [Article Type] Research Article
The impacts of COVID-19 pandemic on public transit demand in the United StatesResearch Article Published on 2020-11-182022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] African American agency Analysis base value Community coronavirus COVID-19 COVID-19 pandemic dimension Essential workers Final function Google Hispanic Impact initial Local Logistic maintain pandemic Population Procruste profile profiles proportion Regression representing Spread spread of COVID-19 systematic analysis the United State The United States [DOI] 10.1371/journal.pone.0242476 PMC 바로가기 [Article Type] Research Article
Citizen-Centered Mobile Health Apps Collecting Individual-Level Spatial Data for Infectious Disease Management: Scoping ReviewReview Published on 2020-11-102022-10-31 Journal: JMIR mHealth and uHealth [Category] COVID-19, [키워드] Analysis analyzed app approaches article automated automated digital contact tracing Bluetooth collected data Collecting Contact tracing COVID-19 Critical described different disease dimension dimensions Diseases distributions effective eight eligibility assessment Epidemic Final FIVE Frequency Hypothesis identify Infectious disease Infectious disease management informatics Intensive Intervention location-based risk assessment management measure Metadata Mobile mobile apps mobility tracking novel coronavirus SARS-CoV-2 objective offer outbreak detection pandemic public health reflected Result review risk Scientific community searched secure selected specific disease Spread Support supported Surveillance systematic analysis technology the disease vector-borne diseases virus [DOI] 10.2196/22594 PMC 바로가기 [Article Type] Review
The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic reviewVirology Published on 2020-11-022022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 95% CI absence Analysis antiviral therapy case-control study cause characterized clinical study clinical trials Combined COVID-19 COVID-19 mortality Critical cytokine drug dysregulated immune response Effect effective Efficacy Evaluating Evidence fatality group hypercytokinemia IL-6 IL-6 inhibitor include interleukin-6 lack lower mortality lymphocytopenia Mortality mortality rate Odds ratio pathophysiological performed positive pro-inflammatory cytokine producing quantitative synthesis random effect Randomized randomized control trial reducing Research Result SARS-CoV-2 severe COVID-19 Standard of care suppress systematic analysis systematic review TCZ the disease Tocilizumab treat Treatment Trial [DOI] 10.7717/peerj.10322 PMC 바로가기 [Article Type] Virology
Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review중증 급성 호흡기 증후군 코로나바이러스 2와 관련된 소아의 다기관 염증 증후군: 체계적인 검토Article Published on 2020-11-012022-09-11 Journal: The Journal of pediatrics [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age assist C-reactive protein cardiovascular Chain Reaction children Clinical symptoms coronavirus criteria demographics develop diagnosed elevated fibrinogen fibrinogen level Fibrinogen levels Gastrointestinal identify inclusion criteria Inflammatory information interleukin interleukin-6 Kawasaki disease laboratory measurements male median age Metadata MIS-C neurologic outcome Patient positive result Prevalence proportion ranged reported Repository representing required respiratory Respiratory system reverse transcriptase review selected serology severe acute respiratory syndrome Coronavirus significantly study inclusion Symptoms syndrome systematic analysis systematic review were assessed [DOI] 10.1016/j.jpeds.2020.08.003 PMC 바로가기 [Article Type] Article
Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer AnalysisMolecular Biosciences Published on 2020-10-232022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 expression ACE2 gene Affect Analysis analyzed B cell breast cancer patients Cancer cancer cell lines cancer patient cancer type cancers carried CD4+ T cells CD8+ T cells China Clinical prognosis conducted Coronavirus disease 2019 correlated correlation COVID-19 COX dendritic cells determine DNA elevated evaluated expressed expression expression level Frequency Functional enrichment analysis global pandemic GSEA HLA gene immune immune infiltration indicated infiltrating investigated Kaplan-Meier lung Macrophage macrophages malignant malignant tumor medium mismatch Mutation Neutrophils not correlated observational study organ Pan-cancer analysis pathway patients with pneumonia positive correlation Prognosis receptor regression analysis repair reported Result risk factor SARS-CoV-2 significantly Spread survival systematic analysis TCGA tested the SARS-CoV-2 virus tissues TMB Tumor tumors with COVID-19 [DOI] 10.3389/fmolb.2020.569414 PMC 바로가기 [Article Type] Molecular Biosciences
Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysisReview Published on 2020-10-232022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus adverse outcomes analysed arrhythmia Arrhythmias Blood C-reactive protein cardiac injury carried Characteristics Chest chest pain clinical Clinical characteristics clinical complications clinical specificity CNKI Comorbidities Comorbidity Complication confirmed case coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 virus creatinine D-dimer determine disease Diseases distress Europe Factor Gender greater higher risk ICU indicate indicated induce Infection Injury Laboratory tests Lymphocyte count male mechanical ventilation Meta analysis Meta-analysis Mortality NT-proBNP objective Older outcomes palpitation Patient patients performed Platelet PMC poor prognosis potential risk procalcitonin proportion reduce Result risk risk factor searched significantly smoking Stata statistical analysis susceptible systematic analysis systematic review transfer [DOI] 10.1017/S0950268820002587 PMC 바로가기 [Article Type] Review
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age childrenAnalysis Published on 2020-10-152022-10-29 Journal: Scientific Data [Category] Coronavirus, MERS, SARS, [키워드] Adults age Analysis assumed Bacterial Bacterial infection children Course COVID-19 pandemic dataset Diseases extreme groups Health immune function immune senescence implication Infection infections Infectious disease information lowest manifestation Older age outcome reached relative Resilience Risk factors severe disease severity Severity of disease systematic analysis Vaccine vaccine response viral infection [DOI] 10.1038/s41597-020-00668-y PMC 바로가기 [Article Type] Analysis
Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2: Rational Design and Multi-Disciplinary Team WorkArticle Published on 2020-09-242022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Analysis approach biosecurity caused Characteristics clinical clinical information coronavirus country COVID-19 COVID-19 pandemic development diagnostic diagnostic test downstream elevated epidemics/pandemics feature glycoprotein IgA immune response include Infection intensity Interpretation MALDI-TOF MS mass National pathogen Protein rapid process reduced reported respiratory viral infection RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus Screening screening test Spectrometry Spread Swab systematic analysis team the SARS-CoV-2 total Ig upper respiratory utility viral envelope viral immune response work [DOI] 10.3390/diagnostics10100746 PMC 바로가기 [Article Type] Article
Human mobility and COVID-19 initial dynamicsOriginal Paper Published on 2020-09-022022-10-30 Journal: Nonlinear Dynamics [Category] COVID-19, [키워드] adopted affected aggregate Analysis antibody screening approach asked conducted Contagion Containment measure contribute coronavirus COVID-19 COVID-19 dynamics data-driven death deaths Europe European European Commission Evolution explain France granularity help Human human mobility IgG IMPROVE information initial International Italy less limit lockdown Measures member Mobility data National notable operator outbreak Outbreaks pandemic positive reduced reducing Spain Spread spread of COVID-19 Still Support systematic analysis virus virus spread [DOI] 10.1007/s11071-020-05854-6 PMC 바로가기 [Article Type] Original Paper