Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachMERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses [DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article
A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4Article Published on 2022-03-082023-07-08 Journal: Stem Cell Reports [Category] COVID19(2023년), [키워드] ACE2 COVID-19 endothelial inflammation IL-1β monocyte adhesion NF-κB p38 MAPK SARS-CoV-2 scRNA-seq TLR4 [DOI] 10.1016/j.stemcr.2022.01.015 PMC 바로가기
Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할Review Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor [DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article
Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)SARS-CoV-2의 세포 친화성, COVID-19의 병태생리학 및 이러한 매개체의 발현을 조절할 수 있는 microRNA의 식별에 연루된 숙주 세포 진입 매개체(검토)Review Published on 2022-02-012022-09-11 Journal: International journal of molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAM17 Affect angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association Basigin binding Biomarker Candidates canonical cell entry cellular tropism changes in Clinical outcome clinical utility complexity coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 dependent on domain enzyme expression expression level Future Genes Glucose Glutamate GRP78 host cell host cells implicated in silico analysis indicated Kidney injury mechanism microRNA miRNA miRNAs modulate Necrosis NPR1 pathophysiology Patient protease Protein provide recent receptor Regulation review SARS‑CoV2 Serine serine 2 severe acute respiratory syndrome Coronavirus therapeutic target TLR4 TMPRSS2 TMPRSS4 transmembrane [DOI] 10.3892/ijmm.2021.5075 PMC 바로가기 [Article Type] Review
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytesArticle Published on 2022-01-282022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] Analysis analyzed bacterial endotoxin Characteristics Chronic diseases chronic inflammation condition contribute COVID-19 driving Epigenetic epigenomic epigenomics evaluate expression Gene Expression Genes High dose High-dose immune induce Inflammation interferon response low dose low-dose low-grade inflammation LPS marrow-derived macrophage memory Modification monocyte murine occur Pathogenesis pathogenic pathway Pathways PBS proliferative Regulation responses Sepsis Signaling target the cell therapeutic TLR4 transcriptomic underlie upregulate while [DOI] 10.1038/s42003-022-03035-2 PMC 바로가기 [Article Type] Article
Potential Genes Associated with COVID-19 and ComorbidityCOVID-19 및 동반이환과 관련된 잠재적 유전자Research Paper Published on 2022-01-242022-09-10 Journal: International Journal of Medical Sciences [Category] 변종, [키워드] ACE AGT Analysis bioinformatics candidate gene CCR5 Comorbidities Comorbidity contribute Coronary artery Coronary artery disease coronavirus coronavirus disease COVID-19 CX3CR1 cytokine cytokine inhibitors cytokine receptor diabetes Diabetes Mellitus disease severity drug and vaccine development Efficacy enrichment analyses evaluated explain Factor Fenofibrate Genetic genetic factors GO term help hypertension IL1B IL1RN IL6 immune factor immune factors immune response IMPROVE individual Infection inhibitors Interaction involved KEGG KEGG pathway MBL2 NCBI NLRP3 non-immune nucleotides observé OMIM overlapping pathway Pathways performed personalised Polymorphisms Potential PPI Predictive Predictive value Prevent Prognosis protein-protein interaction provide RAAS receptor Result risk of infection SARS-CoV-2 serious COVID-19 severity signaling pathway signaling pathways susceptibility susceptibility gene TLR4 Treatment Vaccine Vaccine development Variation Viral viral infection Vitamin D with COVID-19 [DOI] 10.7150/ijms.67815 PMC 바로가기 [Article Type] Research Paper
eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signalingArticle Published on 2022-01-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Activation ARDS Biomarker COVID-19 pandemic Cytokines DAMP dysregulation Evidence Extracellular genotyping IL-6 Inflammation Inflammatory inflammatory cascade inflammatory lung injury intravenous intravenously LPS lung Lung injury mAb molecular Mortality neutralization NFkB nicotinamide pathway plasma preclinical data Preclinical research preserved Protein reduce reduced reduction reduction in regulate Septic shock serum lactate severity Signaling signaling pathway significantly subjects Support therapy TLR4 TNFα unmet need Ventilator-induced lung injury [DOI] 10.1038/s41598-021-04444-9 PMC 바로가기 [Article Type] Article
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행Immunology Published on 2021-12-092022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19 [DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology