COVID-19 wastewater surveillance in rural communities: Comparison of lagoon and pumping station samples농촌 지역 사회의 COVID-19 폐수 감시: 석호 및 펌프장 샘플 비교Article Published on 2021-12-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료제, [키워드] applied Biomarkers Canada Chain Reaction changes in collected Community country COVID-19 downstream Epidemiology fecal granularity implementation incidence incidence of COVID-19 integrity knowledge lagoon limit Mild N1 and N2 pathogen Pathogens Pepper mild mottle virus polymerase chain polymerase chain reaction Prevalence prevalence of COVID-19 pumping station quantification Quantitative Region RNA concentration RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance SARS-CoV-2 viral stability Surveillance Topic Treatment upstream viral signal wastewater wastewater surveillance Wastewater treatment lagoon Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.149618 PMC 바로가기 [Article Type] Article
Nanovaccine Delivery Approaches and Advanced Delivery Systems for the Prevention of Viral Infections: From Development to Clinical ApplicationReview Published on 2021-12-052022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] accelerated administration application authorisation chronic disease clinical Clinicians COVID-19 pandemic delivery development dosage dose downstream Effectiveness Efficacy and safety Frequency immunisation immunoprophylaxis impacts implicated Infection involved manifested nanomaterials Pandemics Patient prevention Regulatory shown stability System upstream Vaccine Vaccines viral infections virus [DOI] 10.3390/pharmaceutics13122091 PMC 바로가기 [Article Type] Review
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 InfectionSARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘, [키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score [DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis
Updated SARS-CoV-2 single nucleotide variants and mortality association업데이트된 SARS-CoV-2 단일 뉴클레오티드 변이체 및 사망률 연관성Article Published on 2021-12-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 진단, [키워드] Affect age alteration Analysis association changed Clustering collected contributing to Critical D614G dominant feature Gender group hydrophobicity immune evasion incidence indicated intrinsic introduced logistic regression model male Mortality mortality risk mortality risk factor Mutation nonsynonymous nonsynonymous mutation nucleotide occur ORF1 ORF1ab ORF7a Patient Protein Protein conformation protein folding protein structure Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes significantly Single nucleotide variant single nucleotide variants single nucleotide variants. SNV SNVs spike subgroup surface area Transmission turn upstream Viral viral pathogenesis virulence [DOI] 10.1002/jmv.27191 PMC 바로가기 [Article Type] Article
Auranofin: Past to Present, and repurposingReview article Published on 2021-12-012022-10-05 Journal: International immunopharmacology [Category] SARS, 신약개발, [키워드] activated acute respiratory syndrome anti-infection Arachidonic acid metabolism auranofin Cancer Cell cell membrane Compound coronavirus cytokine disease Diseases drug Effect electrophilic hydrophobicity Infection Inflammatory inhibited involved mechanism mechanism of action mRNA NF-κB nitric oxide novel Nrf2 oxidative physiological conditions present proinflammatory Protein repurposing responsible rheumatoid arthritis Stress treat Treatment upstream [DOI] 10.1016/j.intimp.2021.108272 [Article Type] Review article
SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVSImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activating Activation attenuate Calu-3 caused cells clinical study COVID-19 cytokine cytokine expression cytokine production effector ENhance expression IL-1β IL-2 IL-6 increase induce infected with SARS-CoV-2 Infectious disease inhibitor investigated knockdown MAVS molecular mechanism NF-κB NF-κB NF-κB activation NF-κB signaling nsp5 overexpression pathway Patient pro-inflammatory cytokine promote Protein protein level Research SARS-CoV-2 SARS-COV-2 infection stability SUMOylation the disease TNF-α Treatment triggering upstream [DOI] 10.3389/fimmu.2021.750969 PMC 바로가기 [Article Type] Immunology
Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENVCOVID-19 및 DENGUE 동시 감염에 대한 케르세틴: SARS-CoV-2 및 DENV에 의해 유발되는 중요한 숙주 신호 경로를 표적으로 하는 잠재적 치료 전략Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] alleviate Analysis bioinformatics biological function Biological functions CCL-2 Clinical characteristics clinical consequence clinical consequences Co-infection Computational biology COVID-19 Critical current CXCL8 Cytokines cytokines release Dengue drug drug trial evaluate Evidence excessive immune response functional Host IL-17 immune responses indicated Inflammation inflammatory pathway inhibit Intervention mechanism mechanisms NF-κB overlapping pathway patients pharmacological pharmacological target potential molecular PPI protein-protein interaction public health quercetin SARS-CoV-2 shown signaling pathways target targets therapeutic therapeutic strategy TNFα Toll-like receptor toll-like receptor signaling Treatment treatment of COVID-19 triggered upstream virus [DOI] 10.1093/bib/bbab199 PMC 바로가기 [Article Type] Article
Phillyrin for COVID-19 and Influenza Co-infection: A Potential Therapeutic Strategy Targeting Host Based on Bioinformatics AnalysisPharmacology Published on 2021-11-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] AKT anti-inflammatory effect bioinformatics Bioinformatics analysis Biological functions biological pathway biological processes Co-infection COVID-19 drug trial expected Genes HIF-1 IL-2 immune indicated Influenza inhibit KEGG Kyoto mechanism MMP9 network pharmacology pathway Pathways pharmacological phillyrin PI3K-Akt signaling Potential PPI previous study Protein–protein interaction Regulation Regulatory Replication risk shown signaling pathway Strategy T cell receptor target targeting targets therapeutic therapeutic potential Treatment upstream VEGFA viruses [DOI] 10.3389/fphar.2021.754241 PMC 바로가기 [Article Type] Pharmacology
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagationSARS-CoV-2 전파를 억제하기 위한 스트레스 과립 단백질 G3BP1/2의 유전체학 유도 표적화Article Published on 2021-11-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Analysis candidate drug candidate drugs COVID-19 mitigation Decitabine docking drug drugs enrichment expression FOXA1 G3BP1 G3BP1/2 G3BP2 Gene Expression Gene set enrichment Genes GTPase Host host cells identify Imatinib inhibit inhibit SARS-CoV-2 Meta-analysis modulating molecular docking analysis much higher N protein nucleocapsid nucleocapsid protein Panel Propagation Protein Proteins regulatory element SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SIN3A SRF Stress stress granule SYK TGFBR2 the SARS-CoV-2 upstream YY1 [DOI] 10.1016/j.ijbiomac.2021.09.018 PMC 바로가기 [Article Type] Article
COVID-19-Associated Pulmonary Aspergillosis, Fungemia, and Pneumocystosis in the Intensive Care Unit: a Retrospective Multicenter Observational Cohort during the First French Pandemic WaveObservational Study Published on 2021-10-202022-10-04 Journal: Microbiology Spectrum [Category] MERS, SARS, 임상, [키워드] age Alter anonymously approach aspergillosis Aspergillus benefit Biomarker Candida albican collected data COVID-19 criteria Critical care death diagnose Diagnosis diagnostic evaluate Factor Factors first positive France French fungal fungal disease fungemia global mortality hospital Hospitalization Host hypotheses ICU ICU admission ICU patient Improved Infection intensive care interquartile range invasive IQR marker means median Mortality mortality rate occurred Occurrence outcome Patient patients with COVID-19 pneumocystosis Pneumonia positive Prevent Prognosis pulmonary recorded respiratory specimen responsible serum serum biomarker specificity Support Treatment upstream Wave with COVID-19 yeast [DOI] 10.1128/Spectrum.01138-21 PMC 바로가기 [Article Type] Observational Study