Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion PeptideSARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] Against Alpha alpha- Analysis antibody Antigen being betacoronaviruses binding broadly neutralizing antibodies conserved coronavirus Coronavirus infection Coronaviruses COVID-19 patients cross-reactive antibody demonstrated disease elicited endemic human coronaviruses epitope exhibited Fc-mediated effector function Fc-mediated effector functions fusion fusion peptide Human human sera immunogenic Infection Kinetics N-terminal Neutralizing activity pepscan peptide Protective S2 subunit SARS-CoV-2 SARS-CoV-2 variants sera severity spike the SARS-CoV-2 therapeutic Viral viral spike [DOI] 10.3389/fimmu.2021.790415 PMC 바로가기 [Article Type] Immunology
No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2Delta 하위 계통 AY.4.2에 의한 증가된 세포 진입 또는 항체 회피에 대한 증거 없음Correspondence Published on 2022-01-052022-09-11 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 진단, [키워드] antibody Antibody evasion AY.4.2 Cell Biology cell entry circulating COVID-19 pandemic Delta driver Drivers Evidence host cell Host cell entry immunology modulate Mutation Neutralizing antibodies Neutralizing antibody response pandemic pathogenicity Protein referred to S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread the S protein Transmissibility variant variants variants of concern Viral viral spike virus while [DOI] 10.1038/s41423-021-00811-8 PMC 바로가기 [Article Type] Correspondence
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection표면에 ACE2 변이체를 표시하는 조작된 작은 세포외 소포는 SARS-CoV-2 감염으로부터 보호합니다Article Published on 2022-01-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 변종, 비임상, [키워드] ACE2 ACE2 variant acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral efficacy antiviral therapeutics Beta Beta variant binding interaction breath carriers CD9 Characteristics clinical trial coronavirus COVID-19 D614G variant Delta delta variant displaying dominant effective delivery Efficacy ENhance enzyme Extracellular extracellular vesicle Extracellular vesicles hACE2 host cell host cell surface Infection inhibit Interaction K18-hACE2 mice L452R molecular PROTECT Protein receptor S protein sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 soluble ACE2 spike the S protein therapeutic efficacy variant variants viral spike wild-type [DOI] 10.1002/jev2.12179 PMC 바로가기 [Article Type] Article
Nanoluciferase-based cell fusion assay for rapid and high-throughput assessment of SARS-CoV-2-neutralizing antibodies in patient samplesArticle Published on 2022-01-012022-11-15 Journal: Molecules [Category] SARS, 변종, 진단, [키워드] 384-well format ACE2 ACE2 receptor antibody applied approach assays automatization biosafety Cell Cell fusion cell lines classical COVID COVID-19 evaluate expressed gold standard Health HiBiT High-throughput host cells human Angiotensin-converting enzyme Immunity in vitro individual Interaction luciferase NanoBiT NanoLuc Neutralization assay Neutralizing antibodies neutralizing capacity Patient Prevent receptor reducing replication-competent virus risk Safe SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2-neutralizing antibody sera spike variants stability substrate syncytium utility vaccinated individuals variant variety viral entry viral neutralization viral spike viral spike protein virus neutralization assay [DOI] 10.1016/bs.mie.2022.07.015 PMC 바로가기
Omicron SARS-CoV-2 Variant Spike Protein Shows an Increased Affinity to the Human ACE2 Receptor: An In Silico AnalysisArticle Published on 2021-12-312022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 ACE2 receptor addition affinity angiotensin-converting enzyme 2 binding affinity binding free energy change changes in charged residues Community contribute docking electrostatic interaction evaluated GISAID HADDOCK host receptor Human human ACE2 human host Increased Interaction modulate Mutation occurred omicron pathogenicity retrieved SARS-CoV-2 SARS-CoV-2 variants show spike Spike protein the SARS-CoV-2 variant variants viral spike virus WT spike [DOI] 10.3390/pathogens11010045 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation423 Published on 2021-12-202022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antiviral target arginine Beta binding caused cell line cellular cleavage cleavage site complement coronavirus coronavirus strains COVID-19 pandemic delta variant functional consequence highlight Host host cell host receptor human ACE2 Infection inhibiting initial mechanism membrane fusion mice molecular molecular mechanism Outbreaks pandemic Prevent primary cell Protein proteolytic proteolytic activation Proteolytic processing Receptor binding Research residue responsible S2 subunit S2′ S2′ cleavage S2′ site SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike variants Significance Spike protein subsequent syncytia formation target cells understanding variety viral entry viral infection viral spike [DOI] 10.1073/pnas.2111199119 PMC 바로가기 [Article Type] 423
Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressureResearch Article Published on 2021-12-132022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, 신종인플루엔자, [키워드] 3D structure antibodies antibody Antibody escape mutation Antibody Response antigenic site approach can be used change circulating coronavirus evade Evolution Factor functional H1N1 identify immune system in-silico Influenza MD simulation modulate mutability mutate Mutation neutralizing antibody occurred offer Pandemics predict Probability Region residue respond S protein sarbecovirus SARS-CoV-2 Seasonal influenza sequence spike target the SARS-CoV-2 the spike protein Vaccine design viral spike viral spike protein viral surface virus viruses [DOI] 10.1371/journal.pcbi.1009664 PMC 바로가기 [Article Type] Research Article
MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challengeArticle Published on 2021-12-032022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] animal model Atypical consolidation COVID-19 pandemic dose ectodomain Efficacy elicited evaluate Evidence exhibited expressing expression of SARS-CoV-2 form full-length S hamster hamsters hemorrhage immune response immunization Immunoglobulin induce less lung majority manifestation mice Microbiology moderate modified vaccinia virus nasal turbinate Nasal washes neutralizing antibody responses Numerous pathology platform Protective Protein provide reduced reduction in reductions in S antigen SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 vaccines serum titer Spike protein tested the RBD utility vaccine candidate Vaccine development Vaccines Vasculitis vector viral replication Viral RNA viral spike virus weight loss [DOI] 10.1038/s41541-021-00410-8 PMC 바로가기 [Article Type] Article
Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regressionCOVID-19에 대한 회복기 혈장: 메타 분석, 시험 순차 분석 및 메타 회귀Meta-Analysis Published on 2021-12-012022-09-11 Journal: British journal of anaesthesia [Category] 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjusted administration angiotensin angiotensin-converting enzyme 2 antibodies association benefit clinical confidence interval convalescent convalescent plasma convalescent plasma treatment coronavirus COVID-19 Disease progression domain evaluate Host host cell host cells ICU admission Interaction mechanical ventilation medRxiv Meta-analysis meta-regression Mild disease Mortality Odds ratio outcome passive immunisation. Patient patients with COVID-19 performed plasma Prevent Primary outcome PROSPERO RCT RCTs receive receptor recruited reduction in Regression risk of death secondary Secondary outcomes sequential analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies systematic review titre Treatment Trial trial sequential analysis TSA viral entry viral spike with mild disease [DOI] 10.1016/j.bja.2021.07.033 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike proteinSARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.Article Published on 2021-12-012022-09-11 Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘, [키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased [DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article