UVC disinfects SARS-CoV-2 by induction of viral genome damage without apparent effects on viral morphology and proteinsArticle Published on 2021-07-052022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis cause Contaminated Contamination coronavirus demonstrated dose Effect electronic microscopy Evidence full-length Genome Health immunoblotting inactivated indicated mechanism Microbiology morphology negative correlation nucleocapsid protein Optics and photonics pandemic Protein R 2 reduced remained RT-PCR assay RT-qPCR SARS-CoV-2 Transmission Treatment ultraviolet C viral genome viral particle Viral proteins viral spike virus virus infectivity virus transmission [DOI] 10.1038/s41598-021-93231-7 PMC 바로가기 [Article Type] Article
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine developmentReview Article Published on 2021-06-022022-10-28 Journal: Open Life Sciences [Category] COVID-19, [키워드] acute respiratory syndrome caused coronavirus coronavirus disease COVID-19 disease economic devastation effective Gamma gamma irradiation genetic material Genome Health Inactivated vaccine inactivation molecular occur pandemic Panic Pneumonia Potential Safe SARS-CoV-2 SARS-CoV-2 virus Vaccine Vaccine development virus virus genome virus inactivation virus infectivity γ-irradiation [DOI] 10.1515/biol-2021-0051 PMC 바로가기 [Article Type] Review Article
Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 InfectionReview Published on 2021-05-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acting affecting Analysis caused chelation Combination component Course COVID-19 demonstrated develop docking effective highlighting inhibition Injury International iron iron chelation metabolism natural natural products Patient product promote protease protease inhibition Protease inhibitor protease inhibitors protocol pulmonary fibrosis recent respiratory diseases role SARS-CoV-2 SARS-COV-2 infection supportive therapies the epidemic therapeutic use viral infection virus infectivity [DOI] 10.3390/jcm10112306 PMC 바로가기 [Article Type] Review
Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2Article Published on 2021-05-172022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] activity aerosol antimicrobial Antiviral antiviral activity coating copper Critical death exhibit filtration flat information media moderate nanoparticle nanosilver Oxide pandemic Particle Plaque assay porous reduce responsible SARS-CoV-2 significantly silver Spread super-spreading event surface modification Transmission viability virus virus infectivity Zinc [DOI] 10.3390/nano11051312 PMC 바로가기 [Article Type] Article
Does blood type affect the COVID-19 infection pattern?Research Article Published on 2021-05-132022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Affect Antigen antigens Blood conserved contagiousness COVID-19 infection COVID-19 pandemic deterministic model distribution Epidemics epidemiological Factor heterogeneity Hypothesis immune reaction Infection infection rate outcome progression receiving SARS-CoV-2 specific antibody Spread subject the disease the epidemic transfer virus virus infectivity [DOI] 10.1371/journal.pone.0251535 PMC 바로가기 [Article Type] Research Article
D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural EffectSARS-CoV-2 스파이크 단백질 헵타드 반복 1의 융합 코어에서 D936Y 및 기타 돌연변이: 빈도, 지리적 분포 및 구조적 효과Article Published on 2021-04-302022-09-10 Journal: Molecules [Category] MERS, SARS, 변종, [키워드] accumulated accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect cellular membrane collected Complete core coronavirus COVID-19 crown Effect Europe Frequency fusion genomic sequence GISAID glycoprotein heptad repeat host cells Infectivity Interaction investigated involved membrane fusion molecular molecular dynamics Mutation mutations N-terminal Other pre-fusion Protein Repeat resource respiratory S protein salt Salt Bridge SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 genomic sequences sequence sequences severe acute respiratory syndrome Coronavirus spike Spike protein Spread strong interactions structures the SARS-CoV-2 USA Viral virus virus infectivity while [DOI] 10.3390/molecules26092622 PMC 바로가기 [Article Type] Article
Indoor Dust as a Matrix for Surveillance of COVID-19Observation Published on 2021-04-132022-10-29 Journal: mSystems [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Asymptomatic disease average built environment Care carrier collected Community coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical digital PCR Disease surveillance dust effort environmental monitoring evaluate Future geometric mean concentration heterogeneity high-risk population individual indoor environment infected individuals matrix methodology mitigate molecular monitoring noninvasive outbreak Outbreaks pandemic pathogen persistence populations positive potential transmission PROTECT public health qPCR Quantitative ranged reverse transcription-PCR RNA RT-qPCR SARS-CoV-2 shown surface Surveillance Swab vaccination vacuum viral disease Viral diseases Viral RNA virus virus infectivity was measured widespread [DOI] 10.1128/mSystems.01350-20 PMC 바로가기 [Article Type] Observation
COVID-19 vaccine development during pandemic: gap analysis, opportunities, and impact on future emerging infectious disease development strategies대유행 중 COVID-19 백신 개발: 격차 분석, 기회 및 미래의 신흥 전염병 개발 전략에 미치는 영향Article Published on 2021-04-032022-08-31 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 신약개발, [키워드] accelerated added addition addressed adjuvants Analysis COVID COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development Critical dosage dosage level effort Emerging infectious disease glassware GMP GMP manufacturing immune immune response Infectious disease Lipid nanoparticle Lipid nanoparticles long-lasting mRNA mRNA vaccine mRNA vaccines mRNA-lipid nanoparticle Neutralizing offer pandemic protective immune response provide regimen Safe stability Stress supply chains Vaccine Vaccine development vaccine dose Vaccines virus infectivity [DOI] 10.1080/21645515.2020.1822136 PMC 바로가기 [Article Type] Article
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2SARS-CoV-2의 스파이크 당단백질 구조에 대한 D614G 치환 효과423 Published on 2021-03-022022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding circulating conformation coronavirus cryo Cryo-electron microscopy cryo-EM D614G D614G substitution electron microscopy facilitate High-resolution initial isolate isolates majority membrane fusion mutant open opening priming promote reason reason for receptor receptor ACE2 reported required respiratory SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus Significance spike spike glycoprotein spike glycoproteins Spike protein Spike proteins spikes structural rearrangement Structure subsequent suggested the SARS-CoV-2 the spike protein variant Viral viral membrane virus virus infectivity viruses [DOI] 10.1073/pnas.2022586118 PMC 바로가기 [Article Type] 423
SARS-Cov2 S Protein Features Potential Estrogen Binding SitePreliminary Communications Published on 2021-03-012022-10-31 Journal: Food Technology and Biotechnology [Category] COVID-19, [키워드] 3D structure Affect appear approach average binding binding site compare protein conserved contribute coronavirus domain Epidemics estradiol Estrogen estrogen binding site estrogen receptor Fatality rate feature Hopefully immune response Infection involved membrane fusion men MERS notable pandemic Potential Proteins receptor reducing Result S protein SARS-CoV2 sequence severity similarity Site Surface glycoprotein Symptom the Coronaviridae the disease the S protein virus infectivity women [DOI] 10.17113/ftb.59.01.21.6820 PMC 바로가기 [Article Type] Preliminary Communications