vaccine candidate – Page 40 – Communicable Diseases Research

An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration

Research Article

Published on 2015-03-152022-10-28
Journal: BMC veterinary research
[Category] Coronavirus,

Cell adhesion as a novel approach to determining the cellular binding motif on the severe acute respiratory syndrome coronavirus spike protein

Article

Published on 2014-02-132022-11-01
Journal: Journal of virological methods
[Category] Coronavirus,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome against SARS-CoV Amino acid analyses approach binding Binding motif binding site caused Cell cellular coronavirus spike protein determine Effect H7N9 Influenza life threatening MERS-CoV Middle East motif MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide pathogen peptide Peptide inhibitor Psychological RBD, receptor-binding domain RBM, receptor-binding motif required residues respiratory syndrome coronavirus S, spike Safe SARS-CoV SARS-CoV spike protein SARS-CoV, severe acute respiratory syndrome-coronavirus Spike protein synthetic peptide the spike protein Therapeutic approach vaccine candidate VERO E6 cells
[DOI] 10.1016/j.jviromet.2014.01.022 PMC 바로가기 [Article Type] Article

Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model

Research Article

Published on 2012-09-242022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] acute infection against SARS-CoV Antiviral antiviral therapeutics approach Coronaviral CoV develop expression ferret ferrets functional gene expression signature help highly pathogenic identify IFN response immune immune protection immune response Immunity immunized Immunopathogenesis inactivated Infected Infection infections Innate innate immune response inoculated IRG lung Lungs Model molecular Pathogenesis pathology prevalent protective immunity provide resource response SARS virus SARS-coronavirus SARS-CoV SARS-CoV infection SARS-like-CoV Vaccine vaccine candidate Vaccines virus
[DOI] 10.1371/journal.pone.0045842 PMC 바로가기 [Article Type] Research Article

A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination

Research Article

Published on 2009-01-132022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirus

Research Article

Published on 2008-11-282022-10-28
Journal: BMC Microbiology
[Category] Coronavirus,

[키워드] absence analyzed antibody Antigen antigenicity antiviral efficacy assays BALB/c mice cloned coronavirus cross-reactivity determined diagnostic effective drugs effective vaccine ELISA Escherichia coli evaluate expressed expression expression vector fluorescent fusion protein HCoV 229E human coronavirus human coronaviruses humoral IFA immunization immunized mice immunoblot induce inhibit injected injection intranasally Laboratory test management mice National neutralization nucleocapsid OC43 Protein Quantitative reactivity Result RT-PCR SARS patient SARS virus Sensitivity and specificity sera T cell proliferation T-cell analysis T-cell Response vaccine candidate Viral load virus replication was performed
[DOI] 10.1186/1471-2180-8-207 PMC 바로가기 [Article Type] Research Article

Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease

Article

Published on 2007-04-092022-11-01
Journal: Virus research
[Category] Coronavirus, MERS,

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Research Article

Published on 2006-12-262022-10-29
Journal: PLoS Medicine
[Category] Coronavirus, Fulltext, 조류인플루엔자,

[키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic
[DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article