vaccine candidate – Page 41 – Communicable Diseases Research

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein

Article

Published on 2017-03-232022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,

A live attenuated mutant of Salmonella Montevideo triggers IL-6, IFN-γ and IL-12 cytokines that co-related with humoral and cellular immune responses required for reduction of challenge bacterial load in experimental chickens

article

Published on 2017-02-282024-09-01
Journal: Comparative Immunology, Microbiology and Infectious Diseases [Category] 살모넬라증,

[키워드] Cytokines deletion mutant protection Salmonella Montevideo vaccine candidate
[Article Type] article

MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques

Research Paper

Published on 2017-02-212022-10-28
Journal: Oncotarget [Category] Coronavirus,

Production of Plasmodium vivax enolase in Escherichia coli and its protective properties

article

Published on 2016-11-302024-09-01
Journal: Human vaccines & immunotherapeutics [Category] 말라리아,

[키워드] Enolase malaria Plasmodium vivax Prokaryotic expression vaccine candidate
[Article Type] article

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Research Article

Published on 2015-10-292022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] addition against SARS-CoV analyzed biosafety carboxy-terminal region causing Cell culture chimeric contributed coronavirus Coronaviruses CoVs deleted Deletion duplication E gene E protein effective epidemic diarrhea full-length Genetic Host identification immune response in vitro in vivo indicated induce insertion interferon response introduced Live attenuated vaccine manuscript mechanism membrane MERS-CoV mice Middle East molecular mechanism morbidity and mortality motif mutant virus mutated Mutation not affect parental passage pathogenicity PEDV phenotype Protective Protein provided recombinant remained restored resulting reversion Safe SARS-CoV SARS-CoV vaccine sequence stability STABLE syndrome the vaccine therapy transmembrane protein understanding Vaccine vaccine candidate Vaccines variant virulence virulent virus virus attenuation virus genome
[DOI] 10.1371/journal.ppat.1005215 PMC 바로가기 [Article Type] Research Article

Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea Virus

Methodology Article

Published on 2015-08-012022-10-28
Journal: BMC veterinary research [Category] Coronavirus,

[키워드] addition Analysis antibody Asia asked assays biotinylated calculated colostrum Coronaviruses correlation country cross-reactivity demonstrated described develop development diagnostic test Disadvantages ELISA epidemic diarrhea expressed fluorescent Fluorescent Focus Neutralization (FFN) Fluorescent microsphere immunoassay (FMIA) functional gastroenteritis highlight IFA Immune status immunoassay immunohistochemistry Interpretation kappa value Laboratory mAb mAbs magnetic bead measurement microsphere MONITOR monoclonal monoclonal antibody multiple antigen naïve Neutralization assay Neutralizing antibodies neutralizing antibody Neutralizing antibody response North North America outbreak pathogen PEDV porcine epidemic diarrhea virus (PEDV) protective immunity quantitation question receiver operating characteristic recent Respiratory Coronavirus Result ROC ROC analysis Sensitivity and specificity Seroconversion Serological assay serology serum serum sample significant level Spread staining strain TGEV vaccine candidate virus virus neutralizing antibodies was performed were used
[DOI] 10.1186/s12917-015-0500-z PMC 바로가기 [Article Type] Methodology Article

Broad protection with an inactivated vaccine against primary-isolated lethal enterovirus 71 infection in newborn mice

Research Article

Published on 2015-07-152023-08-29
Journal: BMC Microbiology [Category] E형 간염,

[키워드] Enterovirus 71 mouse model vaccine candidate
[DOI] 10.1186/s12866-015-0474-9 PMC 바로가기 [Article Type] Research Article

An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration

Research Article

Published on 2015-03-152022-10-28
Journal: BMC veterinary research [Category] Coronavirus,

[키워드] Administered caused Cell culture Complete Culture demonstrated diarrhea disease dose Efficacy ELISA enzyme-linked immunosorbent Epidemic epidemic diarrhea evaluate experimental design FIVE fluorescent foci Genome sequencing help highly pathogenic humoral immune response identity immunoassay immunogenic immunogenicity inactivated Inactivated vaccine infective intramuscularly log microsphere monovalent vaccine negative controls Neutralization assay nucleotide PEDV performed pig Porcine Protective responses Result selected sera significantly higher strain TCID tissue vaccinate Vaccine vaccine candidate virus
[DOI] 10.1186/s12917-015-0357-1 PMC 바로가기 [Article Type] Research Article

Chemically induced Salmonella enteritidis ghosts as a novel vaccine candidate against virulent challenge in a rat model

화학적으로 유도된 살모넬라 엔테리티디스 고스트를 virulent 도전에 대한 새로운 백신 후보로서 쥐 모델에서 사용하기

journal-article

Published on 2014-05-012024-07-31
Journal: Vaccine [Category] 살모넬라증,

[키워드] Bacterial ghosts (BGs) protective immunity Salmonella Enteritidis vaccine candidate
[DOI] 10.1016/j.vaccine.2014.03.090 [Article Type] journal-article

Cell adhesion as a novel approach to determining the cellular binding motif on the severe acute respiratory syndrome coronavirus spike protein

Article

Published on 2014-02-132022-11-01
Journal: Journal of virological methods [Category] Coronavirus,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome against SARS-CoV Amino acid analyses approach binding Binding motif binding site caused Cell cellular coronavirus spike protein determine Effect H7N9 Influenza life threatening MERS-CoV Middle East motif MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide pathogen peptide Peptide inhibitor Psychological RBD, receptor-binding domain RBM, receptor-binding motif required residues respiratory syndrome coronavirus S, spike Safe SARS-CoV SARS-CoV spike protein SARS-CoV, severe acute respiratory syndrome-coronavirus Spike protein synthetic peptide the spike protein Therapeutic approach vaccine candidate VERO E6 cells
[DOI] 10.1016/j.jviromet.2014.01.022 PMC 바로가기 [Article Type] Article