Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential DrugArticle Published on 2021-01-132022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 3C-like protease 3CL Protease acid Analysis antiviral drug Clinical use coronavirus COVID-19 drug Drug repurposing effective effective inhibitor effort Epidemic global pandemic inhibitor main protease morbidity and mortality MPro occurred outbreak Potential protease protease inhibitors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease Spread starting point the Coronaviridae the SARS-CoV-2 therapeutic strategy These data treat Vaccine development virus [DOI] 10.3390/v13010106 PMC 바로가기 [Article Type] Article
Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses Research Published on 2021-01-112022-10-05 Journal: Molecular Psychiatry [Category] 신약개발, [키워드] accelerate Activation adjusted Analysis approach BDNF candidate drug candidate drugs comorbid conditions CYP2D6 disorder Drug repurposing Electronic health record FIVE functional G-protein HTR1B mechanism mechanism of action medication Mortality OPRD1 OPRK1 OPRM1 Pathways Patient patients POMC public health crisis receptors Serotonin Signaling SLC6A4 Substance use disorder treat urgency [DOI] 10.1038/s41380-020-01011-y [Article Type] Research
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)Research Article Published on 2021-01-082022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] acute respiratory distress airway alleviate antiviral agent ARDS Bank COVID-19 drug Drug repurposing drugs exploration faster hACE2 hACE2 receptor human Angiotensin-converting enzyme immune system in vitro in vivo indication Infection Inflammation Influenza virus inhibit inhibitor Interaction investigated modulate molecular molecular docking pandemic peptide peptide-based pharmacological potential benefit predict predicted Prevent protein-protein interaction receptor reduced Regulatory required SARS-CoV-2 spike protein specificity Spike protein stimulate Support syndrome the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Treatment viral infection [DOI] 10.1371/journal.pone.0245258 PMC 바로가기 [Article Type] Research Article
Drug Repurposing: Dipeptidyl Peptidase IV (DPP4) Inhibitors as Potential Agents to Treat SARS-CoV-2 (2019-nCoV) InfectionArticle Published on 2021-01-082022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019-nCoV acute respiratory distress addition agent Antiviral agents approach beta coronavirus caused Compliance computational modeling Computational study Coronavirus-2 cysteine protease cysteine proteases Dipeptidyl peptidase 4 dipeptidyl peptidase IV inhibitors distribution DPP4 drug Drug repurposing Efficacy inhibit inhibitor inhibitors of SARS-CoV-2 investigated M pro MERS-CoV MERS-CoV CLpro molecular docking outbreak pandemic Patient peptidase Potential profiles reduced SAR-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 Mpro dimer SARS-CoV-2 Mpro protomer serine proteases small molecule drug stability syndrome Therapies Treatment type-2 diabete type-2 diabetes Vaccine viable treatment [DOI] 10.3390/ph14010044 PMC 바로가기 [Article Type] Article
Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 TherapeuticsSARS-CoV-2–숙주 단백질–단백질 상호작용체 매핑(Affinity Purification Mass Spectrometry 및 Proximity-Dependent Biotin Labeling: Host-Directed Anti-SARS-CoV-2 치료제 발견을 위한 합리적이고 간단한 경로)Review Published on 2021-01-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advent affinity Affinity purification affinity-purification mass spectrometry Antiviral approach approved drug cellular cellular processe cellular processes coronavirus coronavirus disease COVID-19 Drug discovery Drug repurposing effective emerging experiment Follow-up Generation help high resolution Host host cell host cells host protein identify Interaction interactome life cycle mapping mass mass spectrometry mirage offer outbreak PPI protein interactions protein–protein interactions protein–protein interaction proteomics proximity-dependent biotin labeling (BioID) reduce regulated respiratory route SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spectrometry target targets therapeutic option therapeutic targets Therapeutics Viral viral life cycle virus virus entry virus–host interaction virus–host interactions [DOI] 10.3390/ijms22020532 PMC 바로가기 [Article Type] Review
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patientsCOVID-19 환자의 SARS-CoV-2 복제에 대한 기존 항바이러스 옵션Review Published on 2021-01-062022-09-10 Journal: Future Microbiology [Category] SARS, 신약개발, 치료제, [키워드] (RdRp) 3CLpro Antiviral Antiviral compounds antiviral drug antiviral drugs broad-spectrum antiviral broad-spectrum antivirals chymotrypsin coronavirus COVID-19 COVID-19 patient COVID-19 patients Critical develop Developing disease Drug repurposing effective Efficacy effort evaluated Infection inhibit International life cycle Papain Papain-like protease Pathogenesis PLPro protease RdRP respond RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 replication Spike protein Treatment virus replication virus spike protein [DOI] 10.2217/fmb-2020-0120 PMC 바로가기 [Article Type] Review
COVID-19: inflammatory responses, structure-based drug design and potential therapeuticsReview Published on 2021-01-052023-06-14 Journal: Molecular diversity [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 drug design Drug repurposing Inflammatory responses SARS-CoV-2 [DOI] 10.1007/s11030-020-10176-1 PMC 바로가기 [Article Type] Review
In silico identification of strong binders of the SARS-CoV-2 receptor-binding domainArticle Published on 2021-01-052023-07-06 Journal: European journal of pharmacology [Category] SARS, [키워드] COVID-19 Drug repurposing Receptor-binding domain SARS-CoV-2 Virtual screening [DOI] 10.1016/j.ejphar.2020.173701 PMC 바로가기
Science unites a troubled world: Lessons from the pandemicArticle Published on 2021-01-052022-10-04 Journal: European journal of pharmacology [Category] SARS, 신약개발, [키워드] approach article contributed COVID-19 Culture drug Drug repurposing effective response effort European immunopharmacology introduced journal lesson manuscript molecular docking Molecular modeling offer pandemic Perspective pharmacological treatment Pharmacology Pharmacotherapeutics positive SARS-CoV-2 Science Scientific community scientist severity Spread target unique [DOI] 10.1016/j.ejphar.2020.173696 PMC 바로가기 [Article Type] Article
SARS-CoV-2 therapeutics: how far do we stand from a remedy?Review Published on 2021-01-032023-07-01 Journal: Pharmacological Reports [Category] SARS, [키워드] Antiviral COVID-19 Drug repurposing SARS-CoV-2 target proteins [DOI] 10.1007/s43440-020-00204-0 PMC 바로가기 [Article Type] Review