Neutralizing activity – Page 42 – Communicable Diseases Research

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

COVID-19 임상 스펙트럼 전반에 걸쳐 어린이와 성인에서 SARS-CoV-2에 대한 뚜렷한 항체 반응

Article

Published on 2021-01-012022-09-11
Journal: Nature Immunology [Category] Fulltext, SARS, 임상, 진단, 치료기술, 치료법,

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

인간의 SARS-CoV-2에 대한 기존 및 새로운 체액 면역

Report

Published on 2020-12-112022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, SARS, 조류인플루엔자, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age age distribution anti-S2 antibody antibody repertoire children circulating Cohort contribute coronavirus Course COVID-19 patient COVID-19 patients COVID-19 susceptibility Critical cross-protection cross-react de novo detectable distinguishing distribution Donor exhibited explain flow cytometry HCoV HCoVs Human human coronavirus humans Humoral immunity IgA IgA antibodies IgG IgG antibody IgM IgM antibodies IgM antibody Immunity Immunoglobulin Immunoglobulin G Immunological memory in some individual individuals Infection infection rate memory much higher Neutralizing activity Neutralizing antibodies Novel coronavirus novel coronaviruses observation period Patient Perspective positive Preexisting immunity prevalent proportion recognizing respiratory S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein Science sera severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein subunits susceptibility the SARS-CoV-2 uninfected Wilson Zoonotic introduction
[DOI] 10.1126/science.abe1107 PMC 바로가기 [Article Type] Report

Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency

체액성 면역결핍증 환자의 코로나19 회복기 혈장 매개 소실

Case Reports

Published on 2020-12-052022-09-12
Journal: Cell Reports Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

Long-Term Existence of SARS-CoV-2 in COVID-19 Patients: Host Immunity, Viral Virulence, and Transmissibility

COVID-19 환자에서 SARS-CoV-2의 장기 존재: 숙주 면역, 바이러스 독성 및 전염성

Article

Published on 2020-12-012022-09-11
Journal: Virologica Sinica [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] antibody CD4 CD8 Cell cell supernatant cell supernatants Clinical characteristics clinically coding regions Cohort collected COVID-19 COVID-19 patient cured Cytopathic effect demographic demographic data detectable Existence favor Genome sequencing IFN-γ IgG initial symptom initial symptoms inoculated interferon gamma long-term lymphocyte Lymphocyte functionality Lymphocytes median median age Mild Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples neutralisation Neutralization antibody Neutralizing activity Neutralizing antibodies neutralizing antibody NK cell NK cells nucleic acid test passages pathogenicity Patient patients peripheral positive positively correlated SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 virus Sequencing Spike protein synonymous variant Vero E6 Vero E6 cell VERO E6 cells Viral viral clearance Viral load viral pathogenicity
[DOI] 10.1007/s12250-020-00308-0 PMC 바로가기 [Article Type] Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

SARS-CoV-2 감염 후 중화 항체 및 T 세포 반응의 내구성

Article

Published on 2020-12-012022-09-11
Journal: Frontiers of medicine [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity anti-SARS-CoV-2 blood sample Blood samples caused CD4 CD8 Cell collected convalescent coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient Critical Diagnosis Efficacy ELISA examined IgG IgG antibodies IgG antibody IgGs Immunity Infection interferon investigated memory N-protein Neutralizing activity Neutralizing antibodies neutralizing antibody no difference offer pandemic positive Post-infection predominant Probability pseudovirus respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus specimen T-cell T-cell Response triggered vaccination Vaccine variant variant of SARS-CoV-2 variants of SARS-CoV-2
[DOI] 10.1007/s11684-020-0822-5 PMC 바로가기 [Article Type] Article

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

RBD-Fc 기반 COVID-19 백신 후보, 매우 강력한 SARS-CoV-2 중화 항체 반응 유도

Article

Published on 2020-11-272022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Antisera binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs domain dominant Economy effective Effective vaccines elicited Epitopes Fc fragment fragment of global health Health human ACE2 IgG immunization Immunopotentiator induce Infection infections live SARS-CoV-2 mice mutants natural mutation natural mutations neutralization neutralize Neutralizing activity neutralizing epitope pandemic Prevent PROTECT pseudotyped pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific antibodies RBD-specific antibody receptor Receptor-binding domain respiratory responsible robust Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-related coronavirus SARSr-CoV SARSr-CoVs severe acute respiratory syndrome Coronavirus specific antibodies Spike protein subunit Subunit vaccine the SARS-CoV-2 the spike protein threat transgenic mice Vaccine Vaccines
[DOI] 10.1038/s41392-020-00402-5 PMC 바로가기 [Article Type] Article

Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients

COVID-19 환자의 혈청에서 수개월 동안 SARS-CoV-2에 대한 중화 활성 지속

Article

Published on 2020-11-272022-09-01
Journal: Viruses [Category] SARS, 진단, 치료법,

Serologic Evaluation of Healthcare Workers Caring for COVID-19 Patients in the Republic of Korea

Microbiology

Published on 2020-11-202022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] activities acute respiratory syndrome aerosol-generating procedure antibody Care conducted coronavirus disease COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients enzyme-linked immunosorbent evaluate evaluated Guidance HCW HCWs healthcare worker IgG IgG antibody immunoassay Immunoglobulin Infection prevention initial screening laboratory-confirmed Microneutralization test multicenter Neutralizing activity occur pandemic performed Personal protective equipment positive positive result Respirator risk SARS-CoV-2 SARS-CoV-2 transmission screening strategy Seroconversion serologic serology seropositive South Korea specimens subclinical infection Transmission virus was used were used worker
[DOI] 10.3389/fmicb.2020.587613 PMC 바로가기 [Article Type] Microbiology

Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals

Research

Published on 2020-11-162022-10-05
Journal: Nature Microbiology [Category] SARS, 치료기술, 치료법,

[키워드] acute respiratory syndrome antibody Antibody Response Asymptomatic autoantibodies B-cell benefit caused Cell circulating coronavirus Coronavirus disease 2019 COVID-19 COVID-19-convalescent individual COVID-19-convalescent individuals cross-neutralizing antibody response cross-reactivity detectable disease early phase facilitate faster follicular Frequency functional help increase in individual individuals with COVID-19 Infection Lymphocyte count majority Middle East Mild moderate Neutralizing activity neutralizing antibody Neutralizing antibody response neutralizing antibody titre neutralizing antibody titres other coronavirus Patient Pseudotyped virus Pseudotyped viruses respiratory syndrome coronavirus SARS-CoV SARS-COV-2 infection SARS-CoV-2 spike serum severe COVID-19 Symptom symptom onset the antibody the SARS-CoV-2 Treatment Vaccine Vaccine development
[DOI] 10.1038/s41564-020-00824-5 [Article Type] Research

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Article

Published on 2020-11-132022-10-04
Journal: Nature Communications [Category] SARS, 변종, 신약개발, 치료제,

[키워드] ACE2 ADE angiotensin-converting enzyme 2 antibodies antibody Antibody-dependent enhancement Antiviral binding block characterization convalescent patient COVID-19 disrupting eliminated Fc region FcγRIIb Infection Interaction interfere Intervention LALA mAb monoclonal antibody Mutation Neutralizing activity neutralizing antibody non-human primates potent prevented Prophylactic prophylactic treatment RBD receptor Receptor binding domain Rhesus monkey Rhesus monkeys SARS-CoV-2 SARS-CoV-2 spike single dose therapeutic activity therapeutic effect therapeutic efficacy Therapeutic treatment Translational immunology Treatment
[DOI] 10.1038/s41467-020-19568-1 PMC 바로가기 [Article Type] Article