Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory AxisMicrobiology Published on 2020-09-222022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome approach axis Basis Can cell types changes in coronavirus Coronavirus infectious disease 2019 COVID-19 Diagnostic method ENCODE homeostasis host cells Human human cells induce infected cells Infectious disease insight Like mass-spectrometry modulating molecular multifunctional protein nasal olfactory olfactory dysfunction patients with COVID-19 proteomic proteomics replicate RNA viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus-2 Smell triggered [DOI] 10.3389/fmicb.2020.02101 PMC 바로가기 [Article Type] Microbiology
Quantitative proteomic analysis of the tizoxanide effect in vero cellsArticle Published on 2020-09-072022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] Analysis antimicrobial effect antiviral activity approach approved Bacteria biological processes Biotechnology Brazil Cell cell metabolism cells circulating clinical trial clinical trials COVID-19 differentially expressed effective engage FASN in vitro in vitro results mechanism metabolite microorganisms Modification nitazoxanide Protein proteomic proteomics RNA Signal transduction tizoxanide translation Treatment USA Vero Cell viruses [DOI] 10.1038/s41598-020-71634-2 PMC 바로가기 [Article Type] Article
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 ReplicationArticle Published on 2020-08-112023-07-02 Journal: Molecular Cell [Category] SARS, [키워드] COVID-19 Drug repurposing Phosphoproteomics PI3K proteomics RAS SARS-CoV-2 Signaling TMT viral replication [DOI] 10.1016/j.molcel.2020.08.006 PMC 바로가기
Coronavirus in cat flea: findings and questions regarding COVID-19Letter to the Editor Published on 2020-08-102022-10-28 Journal: Parasites & Vectors [Category] COVID-19, MERS, [키워드] ACE acting acute respiratory syndrome affected Angiotensin-converting enzyme Arthropod beta-coronavirus cat caused cell receptor coronavirus coronavirus disease COVID-19 COVID-19 disease Ctenocephalide disease disease risk dissemination Evidence Factors Flea Host humans implication Ixode pandemic proteomics question raised recent reservoir risk of transmission SARS-CoV SARS-CoV-2 Spread suggested Support Transmission vector Viremia virus attenuation [DOI] 10.1186/s13071-020-04292-y PMC 바로가기 [Article Type] Letter to the Editor
Lights and Shadows of TORCH Infection ProteomicsReview Published on 2020-08-052024-09-02 Journal: Genes [Category] 대상포진, [키워드] Congenital abnormalities infections mass spectrometry Pregnancy proteomics TORCH [DOI] 10.3390/genes11080894 PMC 바로가기 [Article Type] Review
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptorArticle Published on 2020-08-042023-08-30 Journal: Nature Communications [Category] E형 간염, [키워드] Chemical tools proteomics Virus-host interactions [DOI] 10.1038/s41467-020-17638-y PMC 바로가기 [Article Type] Article
Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cellsResearch Article Published on 2020-07-312022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] 24 hour acute respiratory syndrome Akt/mTOR/HIF-1 Analysis cellular cellular response Coronavirus-2 Course COVID-19 dose-dependent activation downstream effector molecule engage ErbB HIF-1 HIF-1α Host hpi Huh7 cell in vitro infected cell Infection inhibition inhibitor Innate immunity management MK-2206 modulated molecular mTOR signaling pathway Pathways patients performed post infection potential therapy proteomics reduction in required S6K1 SARS-CoV-2 SARS-CoV-2 infected cell severe coronavirus disease Signaling signaling pathways the SARS-CoV-2 TNF signaling transcriptomics virus virus production [DOI] 10.1080/22221751.2020.1799723 PMC 바로가기 [Article Type] Research Article
COVID-19-Related Coagulopathy—Is Transferrin a Missing Link?Communication Published on 2020-07-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] ADAMTS13 age analyzed Anticoagulants binding C1QTNF1 Coagulation Coagulopathy contribute contributing to COVID-19 COVID-19 disease database dataset decrease Disseminated intravascular coagulation expression expression of gene F11 female Gene ontology gene product HGFAC identify increase individual KLKB1 male males mechanism missing procoagulant Protein proteomics regulated risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2-infected cell SERPINA5 severe COVID-19 disease thrombosis Transferrin upregulated [DOI] 10.3390/diagnostics10080539 PMC 바로가기 [Article Type] Communication
Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccinesResearch Article Published on 2020-07-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] amplification analysed Analysis Antigen biological processe can be used change characterized condition coronavirus COVID-19 drug target effective effort globe host cell host response inactivated include infection kinetics information mass spectrometry modulated new virus overcome pandemic platform Prevent produced proteome proteomics resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell shotgun Spread Tandem mass spectrometry Vaccine Vaccine development viral amplification viral particle Viral particles viral protein detection virus [DOI] 10.1080/22221751.2020.1791737 PMC 바로가기 [Article Type] Research Article
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 InfectionArticle Published on 2020-07-222022-10-04 Journal: Cell Systems [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] antiviral immune response approach batch effect Biomarker build Classifier clinical clinical classifiers clinical decision Clinical use Coagulation system Cohort collected complement COVID-19 COVID-19 infection COVID-19 pandemic diagnostic differentially expressed downstream facilitate Factors generate high-throughput proteomics Hospitalized hospitalized COVID-19 patients hypothese identify implementation include Infection Inflammation Longitudinal studies mass spectrometry pandemic per day platform point-of-care Potential biomarker Precision pro-inflammatory factor Protein proteome proteomic proteomics protocol quantification reduce regulated required serum and plasma severity Standardization Support SWATH-MS the SARS-CoV-2 the WHO therapeutic targets upstream WHO with COVID-19 [DOI] 10.1016/j.cels.2020.05.012 PMC 바로가기 [Article Type] Article