Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An in silico approachSARS-CoV-2 스파이크 수용체 결합 도메인에 대한 잠재적 억제제 식별을 위한 약물 용도 변경: 실리코 접근법Article Published on 2021-01-012022-09-24 Journal: The Indian journal of medical research [Category] 신약개발, [키워드] analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral activity antiviral drug antiviral drugs approach AutoDock binding energy carried caused chalcone clinical investigation computational tool coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics crystal structure daclatasvir docking dolutegravir domain drug Drug repurposing drug-target interaction drugs effective enzaplatovir enzyme Favipiravir Grazoprevir highest binding affinity in silico in silico Approach Infection information inhibitor Laboratory molecular molecular docking molecular docking analysis molecular dynamics predicted presatovir present Protein RBD RBD of SARS-CoV-2 reactivity Receptor-binding domain Remdesivir reported S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike Simeprevir simeprevir. therapeutic efficacy tideglusib was performed [DOI] 10.4103/ijmr.IJMR_1132_20 PMC 바로가기 [Article Type] Article
Repurposing Antimalarials to Tackle the COVID-19 PandemicCOVID-19 전염병에 대처하기 위해 항말라리아제의 용도 변경Review Published on 2021-01-012022-08-31 Journal: Trends in parasitology [Category] SARS, 신약개발, 치료제, [키워드] acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory effects antimalarial Antiviral Artemisinin artemisinins artesunate artesunate/pyronaridine Clinical studies clinical study combination therapies combination therapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infections cytokine Cytokine storm demonstrated Drug repurposing Effectiveness Evidence IL-6 in vitro interleukin interleukin-6 pyronaridine repurposing respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe coronavirus disease shown Support [DOI] 10.1016/j.pt.2020.10.003 PMC 바로가기 [Article Type] Review
Triazavirin might be the new hope to fight Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)Article Published on 2021-01-012023-06-23 Journal: Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a [Category] SARS, 신종인플루엔자, [키워드] 3-chymotrypsin-like protease ACE-2 COVID-19 Drug repurposing SARS-CoV-2 structural proteins triazavirin
Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing StudySARS-CoV-2 주요 프로테아제 표적화: 컴퓨터 약물 용도 변경 연구Article Published on 2021-01-012022-08-31 Journal: Archives of medical research [Category] SARS, 신약개발, 치료제, [키워드] 6LU7 acute respiratory syndrome acute respiratory syndrome coronavirus-2 approach approved approved drug aprepitant arbutin barnidipine clinically coronavirus disease COVID-19 Dexamethasone docked docking docking score docking scores docking tool drug Drug discovery Drug repurposing drug-target DrugBank drugs electrostatic interactions exploration Favipiravir FIVE hydrophilic hydrophobic in silico in viral inhibit Ligand limitation M pro M(pro) management molecular molecular dynamics molecular dynamics simulations molecular interaction novel Novel coronavirus novel coronavirus disease pandemic protease Protein Remdesivir Replication reported repurposing researcher respiratory SARS-CoV-2 Schrodinger Severe acute respiratory syndrome Standard Structure targeting targets terbutaline tipiracil Treatment US-FDA Vaccine development Viral viral replication Virtual screening [DOI] 10.1016/j.arcmed.2020.09.013 PMC 바로가기 [Article Type] Article
Computational drug discovery and repurposing for the treatment of COVID-19: A systematic reviewCOVID-19 치료를 위한 컴퓨터 약물 발견 및 용도 변경: 체계적인 검토Article Published on 2021-01-012022-08-31 Journal: Bioorganic chemistry [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] AIDS Analysis Anticoagulant anticoagulant drug antiviral drug antiviral drugs applied approved approved drug approved drugs article asunaprevir Atazanavir AutoDock AutoDock vina best boceprevir Chloroquine clinical evidence clinical study Clocortolone CMV Computational drug computational method Computational methods COVID-19 COVID-19 progression COVID-19 therapy COVID-2019 crystal structure Dabigatran darunavir database disease disease outbreak docking tool dolutegravir drug Drug discovery Drug repurposing drugs Ebola efavirenz Efficacy eligible English entecavir FIVE formoterol Future Ganciclovir Grazoprevir HBV HCV Indinavir inhibit itraconazole life-threatening list Lomibuvir Lopinavir majority matter mechanism molecular mycophenolic acid nelfinavir non-structural protein non-structural proteins Novel coronavirus occurred offer outbreak Papain Papain-like protease Penciclovir protease provide raltegravir Remdesivir Repurposed drug Repurposed drugs ribavirin Ritonavir RNA-dependent RNA polymerase saquinavir SARS-CoV-2 SARS-CoV2 sequence Simeprevir systematic review telaprevir the disease therapeutic therapy treat Treatment treatment of COVID-19 [DOI] 10.1016/j.bioorg.2020.104490 PMC 바로가기 [Article Type] Article
COVID-19 drug repurposing: A review of computational screening methods, clinical trials, and protein interaction assaysCOVID-19 약물 용도 변경: 컴퓨터 스크리닝 방법, 임상 시험 및 단백질 상호 작용 분석에 대한 검토Review Published on 2021-01-012022-08-31 Journal: Medicinal research reviews [Category] 신약개발, 임상, [키워드] clinical trial clinical trials Clinicians computational research coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment creation drug drug combinations Drug development Drug discovery Drug repurposing effective Efficacy experiments facilitate globe groups in vitro in vitro protein interaction assay. information Interaction mechanism organized pandemic pharmaceutical industry Protein Providing Research researcher screening methods situation the disease therapeutic Treatment [DOI] 10.1002/med.21728 PMC 바로가기 [Article Type] Review
Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?이버멕틴의 흡입 경로 및 항염 작용: COVID-19와의 싸움에서 약속이 있습니까?Article Published on 2021-01-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, 치료제, [키워드] Administered administration anti-inflammatory action antiviral activity approved broad spectrum Clinical studies clinically coronavirus COVID-19 demonstrated DNA and RNA dose doses drug Drug repurposing effective effort global pandemic hypothesise hypothesised IC50 In-vitro Inhaled interfere Ivermectin lung Lungs nucleus oral administration prevention of COVID-19 Protein repurposing respiratory Respiratory illness RNA viruses SARS-CoV-2 SARS-CoV-2 nucleocapsid Scientific community severe respiratory illness Transport Treatment treatment strategy virus viruses [DOI] 10.1016/j.mehy.2020.110364 PMC 바로가기 [Article Type] Article
Repurposed drugs and nutraceuticals targeting envelope protein: A possible therapeutic strategy against COVID-19엔벨로프 단백질을 표적으로 하는 용도 변경 약물 및 기능식품: COVID-19에 대한 가능한 치료 전략Article Published on 2021-01-012022-08-31 Journal: Genomics [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] absence AI based screening Amino acid Anti-viral therapy approved artificial intelligence assembly caused claimed CoV COVID-19 docking drug drug designing Drug repurposing E protein FDA Host infected patients initial screening involved Ligand ligands mechanism membrane protein molecular docking Molecular docking simulations nutraceutical nutraceuticals pandemic pattern Pattern recognition performed Protein provided SARS-CoV-2 SARS-COV-2 infection Symptom target protein therapeutic strategy virus [DOI] 10.1016/j.ygeno.2020.11.009 PMC 바로가기 [Article Type] Article
Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico studyResearch article Published on 2021-01-012022-10-05 Journal: Journal of Molecular Structure [Category] 신약개발, [키워드] approach binding binding energy biological system carried complexes database Degradation diabete docking docking score drug Drug repurposing evaluate FDA approved drug finding functional Heart diseases identify in-silico inhibitor inhibitors Interaction kidney Ligand malignancies molecular molecular docking molecular dynamics neprilysin Neutral obesity pathological conditions pathology peptide performed physiological Precision reported repurposing screened similarity tested therapeutic effect therapeutic target Virtual screening was used [DOI] 10.1016/j.molstruc.2020.129073 [Article Type] Research article
Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulationsArticle Published on 2020-12-312023-07-01 Journal: European journal of pharmacology [Category] SARS, [키워드] Antiviral COVID-19 Drug repurposing Influenza virus membrane fusion pandemic protein interaction Receptor-binding domain umifenovir [DOI] 10.1016/j.ejphar.2020.173836 PMC 바로가기