Can Individuals with Suboptimal Antibody Responses to Conventional Antiviral Vaccines Acquire Adequate Antibodies from SARS-CoV-2 mRNA Vaccination?기존의 항바이러스 백신에 대한 항체 반응이 최적이 아닌 개인이 SARS-CoV-2 mRNA 백신 접종을 통해 적절한 항체를 얻을 수 있습니까?Article Published on 2022-05-032022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adequate Anti-spike anti-spike antibodies anti-spike antibody antibody Antibody titers BNT162b2 BNT162b2 mRNA vaccine Can Chickenpox Conventional conventional vaccines coronavirus coronavirus disease Coronavirus disease 2019 detectable dose exhibited first vaccination HCW HCWs healthcare worker Healthcare workers hepatitis B immune response immune responses individual Japan measles mRNA mRNA vaccine mumps Neutralizing neutralizing antibody nosocomial Nosocomial infection of BNT162b2 Prevent prospective cohort study reduced respiratory Responder responders response rubella SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody second vaccination severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 vaccination Vaccine was measured were measured [DOI] 10.3390/v14050956 PMC 바로가기 [Article Type] Article
Lower persistence of anti-nucleocapsid compared to anti-spike antibodies up to one year after SARS-CoV-2 infectionSARS-CoV-2 감염 후 최대 1년까지 항스파이크 항체에 비해 항뉴클레오캡시드의 더 낮은 지속성Article Published on 2022-05-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Abbott anti-S Anti-spike anti-spike antibody antibody COVID-19 COVID-19 testing Evolution half-lives IgG immunoassay immunoassays infected patient less Lower non-severe patient non-severe patients nucleocapsid peak persistence positive RT-PCR SARS-CoV-2 SARS-COV-2 infection Serological testing Seronegativity severe COVID-19 patients severe SARS severe SARS-CoV-2 significantly higher spike university hospital [DOI] 10.1016/j.diagmicrobio.2022.115659 PMC 바로가기 [Article Type] Article
Recombinant subunits of SARS-CoV-2 spike protein as vaccine candidates to elicit neutralizing antibodies중화 항체를 유도하기 위한 백신 후보로서의 SARS-CoV-2 스파이크 단백질의 재조합 소단위Article Published on 2022-05-012022-09-12 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody anti-spike antibody antibody Antibody titer checked Combination COVID-19 COVID-19 patient Critical effective Efficiency elicit evaluated fusion peptide in silico in vitro in vivo experiments Infection injected injection Live virus long-lasting mice neutralization neutralize Neutralizing neutralizing antibody neutralizing antibody responses produced Protein Proteins RBD recombinant Recombinant protein recombinant proteins reported robust S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus serum serum samples shown Spike protein stimulate subunit Subunit vaccine target the SARS-CoV-2 vaccination against COVID-19 Vaccine vaccine candidate Vaccine design VNT was increased were measured were used [DOI] 10.1002/jcla.24328 PMC 바로가기 [Article Type] Article
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients면역 저하 환자의 COVID-19 mRNA 백신에 의한 우려 변종에 대한 체액 반응Article Published on 2022-05-012022-09-11 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019-nCoV Against age All participant All participants Alpha anti-spike antibody Antibody titer Antibody titers association Autoimmune disease Autoimmune diseases best Beta Beta variant binding BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Cancer cancers circulating concern conducted COVID-19 decrease Delta delta variant Delta variants dose Effectiveness elicited enrolled female Gamma greater healthy control healthy controls hematologic Humoral response humoral responses IgG Immunocompromised patient Immunocompromised patients median Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 NAb NAb responses NAbs nCoV neutralizing antibody neutralizing antibody titers outcome participant Participants Patient patient population performed persistence Pfizer-BioNTech Primary outcome proportion proportions response response to vaccination responses against SARS-CoV-2 SARS-CoV-2 variants secondary outcome solid cancers solid organ solid organ transplant solid organ transplants study group the healthy the patient the SARS-CoV-2 Treatment underlying disease university vaccination vaccination schedule Vaccine Vaccines variant variants variants of concern VoC VOCs were measured [DOI] 10.1001/jamaoncol.2022.0446 PMC 바로가기 [Article Type] Article
HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19SARS-CoV-2 감염의 HLA-DR 다형성 및 증상이 있는 COVID-19에 대한 감수성Article Published on 2022-05-012022-09-11 Journal: Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age allele analysed Analysis anti-spike antibody antibody association asymptomatic infection Comorbidity COVID COVID-19 death disease dose DRB1 Gender genomic variation Genotype HCW HCWs healthcare worker HLA HLA-DR HLA-DRB1 HLA-DRB1* Host human leukocyte antigen immune response immune responsiveness Immunogenetics imputation include increased risk Infection investigated leukocyte Mild nucleocapsid nucleoprotein outcome PCR polymorphism reason recruited SARS-CoV-2 SARS-COV-2 infection second dose seroconverted severe disease susceptibility Symptom symptomatic symptomatic COVID-19 T-cell T-cell immunity T-cell Response T-cell responses titre Trial registration vaccination Vaccine vaccine doses [DOI] 10.1111/imm.13450 PMC 바로가기 [Article Type] Article
SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex스파이크-ACE2 복합체 기반 SARS-CoV-2 전기화학 면역센서Article Published on 2022-05-012022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme anti-spike antibody antibody buffer complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect Diagnosis enzyme gold healthy individual horseradish peroxidase host receptor HRP immunosensor infected patient infected patients Interaction limit of detection magnetic bead Magnetic beads measure mediator mitigate Nasopharyngeal swab nasopharyngeal swab sample Pandemics Particle Particles peroxidase proof Protein pseudovirions Rapid reporter reproducibility resulting Sandwich SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus spike Spike protein the patient the spike protein viral particle Viral particles virus was recorded [DOI] 10.1016/j.aca.2022.339718 PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T-cell responseCOVID-19 백신 접종에 대한 면역 반응은 백신 주도의 발산 T 세포 반응을 통한 질병 통제 및 항골수종 요법에 의해 약화됩니다.Article Published on 2022-05-012022-09-11 Journal: British Journal of Haematology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] administration anti-CD38 Anti-spike anti-spike antibody antibody Antibody Response Antigen B-cell Bacterial blood sample Blood samples Cellular immune response cellular response Clinical significance COVID-19 vaccination COVID-19 vaccine disease disease severity Gender humoral humoral immune response immune responses interferon gamma male maturation Myeloma Patient patients Pfizer-BioNTech positive positive result predicted produced Prospective Study Protein provided reported required respond poorly response serology study cohort T-cell Response therapy vaccination Vaccine vaccine dose Viral [DOI] 10.1111/bjh.18066 PMC 바로가기 [Article Type] Article
COVID-19 Vaccine Responses in Patients With Plasma Cell Dyscrasias After Complete Vaccination완전한 백신 접종 후 형질 세포 이상증 환자의 COVID-19 백신 반응Article Published on 2022-05-012022-09-11 Journal: Clinical lymphoma, myeloma & leukemia [Category] MERS, 진단, 치료법, [키워드] adenoviral vector vaccine Administered age anti-CD38 anti-spike antibodies anti-spike antibody antibody Antibody Response Antibody responses Antibody testing Cell clinical history Complete consecutive patient consecutive patients COVID-19 COVID-19 vaccination detectable drug therapy dyscrasia evaluated Evidence evidence of examined functional heterologous mRNA vaccine Hypogammaglobulinemia Immunocompromised increased risk Infection IVIG Johnson & Johnson Johnson & Johnson management Moderna monoclonal antibody monoclonal antibody therapy mRNA vaccine Multiple Multiple myeloma Multivariate analysis negatively affected nucleocapsid Patient plasma Plasma cell Plasma Cell Dyscrasias Quantitative receiving response responses Roche SARS-CoV-2 second dose serologic Serologic response spike Spike antibody detection tested the timing therapy Treatment vaccination Vaccine Vaccine boosters. Vaccines were excluded were measured [DOI] 10.1016/j.clml.2021.11.001 PMC 바로가기 [Article Type] Article
SARS-CoV-2 antibody testing for transplant recipients: A tool to personalize protection versus COVID-19이식 수혜자를 위한 SARS-CoV-2 항체 테스트: COVID-19에 대한 개인화 보호 도구Article Published on 2022-05-012022-09-12 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Anti-spike anti-spike antibody Antibody testing COVID-19 drug effort food IMPROVE monoclonal antibody powerful tool Prophylaxis recipient recipients response risk risk stratification SARS-CoV-2 antibody testing SARS-CoV-2 vaccine Seronegativity Society solid organ transplant SOT tested testing antibody transplantation vaccination Vaccination strategy [DOI] 10.1111/ajt.16993 PMC 바로가기 [Article Type] Article