Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire질량분석법에 의한 차세대 혈청학: SARS-CoV-2 항체 레퍼토리 판독Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody Antibody detection Antigen applied Autoimmune disorders B cells capture captures Clonality clone COVID-19 data type degree heavy chains heterogeneity immune response immune responses Immunity immunized Immunoglobulin individual ion mass spectrometry Ion mass mass spectrometry Metrics Mild molecular pathogen Pathogens plasma Protein proteomics RBD Receptor-binding domain Region repertoire SARS-CoV-2 Sequencing serological serology Spike protein subject the receptor-binding domain the SARS-CoV-2 the spike protein titer top-down mass spectrometry. vaccination vaccine doses variable regions [DOI] 10.1021/acs.jproteome.1c00882 PMC 바로가기 [Article Type] Article
SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements소아에서 SARS 항체 검사: IgG 측정을 위한 구강액 분석법 개발Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval Adults antibody antibody kinetics barrier best Blood capture children collected COVID-19 development enzyme immunoassay enzyme immunoassays exposure to healthy children IgG Infection Laboratory less measurement MONITOR oral oral fluid pandemic pediatric populations primary endpoint Protein RBD RBD antigen reducing Saliva SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 surveillance SARS-CoV-2 viral School Schools sensitivity Sensitivity and specificity serum serum antibodies specificity Spike protein Spread Surveillance surveys target population Testing transudate United Kingdom venipuncture Viral were assessed [DOI] 10.1128/spectrum.00786-21 PMC 바로가기 [Article Type] Research Article
A novel multiplex electrochemiluminescent immunoassay for detection and quantification of anti-SARS-CoV-2 IgG and anti-seasonal endemic human coronavirus IgG항-SARS-CoV-2 IgG 및 항-계절성 풍토병 인간 코로나바이러스 IgG의 검출 및 정량화를 위한 새로운 다중 전기화학발광 면역분석법Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] anti-SARS-CoV-2 IgG antibody Antigen antigens assays assigned calculate Canada capture collected coronavirus Coronaviruses COVID-19 cut-offs Endemic endemic human coronavirus endemic human coronaviruses Human human coronavirus humoral Humoral response IgG immunoassay immunoassays index case Infection MSD multiplex multiplex serology nine no difference nucleocapsid Panel performance positive Protein public health quantification RBD Sample SARS-CoV-2 SARS-CoV-2 PCR scale sensitivities sensitivity Sensitivity and specificity sera Serological assay serology Specificities specificity spike Spike protein surface plasmon surface plasmon resonance target target sensitivity targets test results tested the Spike vaccination were used [DOI] 10.1016/j.jcv.2021.105050 PMC 바로가기 [Article Type] Article
Rational Programming of Cas12a for Early-Stage Detection of COVID-19 by Lateral Flow Assay and Portable Real-Time Fluorescence Readout Facilities측면 흐름 분석 및 휴대용 실시간 형광 판독 시설에 의한 COVID-19의 초기 단계 탐지를위한 CAS12A의 합리적 프로그래밍Article Published on 2021-12-262022-09-01 Journal: Biosensors [Category] 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] alternative method approach capture caused cleavage clinical nasopharyngeal samples complementary complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas12a detection develop Diagnosis diagnosis of COVID-19 diagnostics DNA facility fixed Flow Fluorescence fluorescence detection fluorophotometer global pandemic imperative integration isothermal amplification knowledge Lateral lateral flow lateral flow strip Loop-mediated isothermal amplification mechanism N genes nasopharyngeal sample pathogenicity portable real-time fluorescence detector probe reporter reverse transcription RT-LAMP RT-PCR kit SARS-CoV-2 SARS-CoV-2 virus sensitivity specificity Spread test line the SARS-CoV-2 virus Transmission [DOI] 10.3390/bios12010011 PMC 바로가기 [Article Type] Article
The co-circulating transmission dynamics of SARS-CoV-2 Alpha and Eta variants in Nigeria: A retrospective modeling study of COVID-19나이지리아의 SARS-CoV-2 알파 및 에타 변이체의 동시 순환 전파 역학: COVID-19의 후향적 모델링 연구Research Theme 1: COVID-19 Pandemic Published on 2021-12-252022-09-10 Journal: Journal of Global Health [Category] MERS, SARS, 변종, [키워드] Alpha Alpha variant B.1.1.7 B.1.525 capture contributing to COVID-19 COVID-19 pandemic credible intervals Critical decrease disease disease control epidemic wave epidemiological Eta Evidence evidence of Health care Health care system health care systems interval mathematical mathematical model measure Mutation Nigeria outbreak outcome prevalent public health Reproduction number reproduction numbers Result retrospective SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants strain Strains suggested surveillance data threat Transmission Transmission dynamics variant variants wild type [DOI] 10.7189/jogh.11.05028 PMC 바로가기 [Article Type] Research Theme 1: COVID-19 Pandemic
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcomeCOVID-19 환자 혈청의 비표적 대사체학은 심각성과 결과 모두의 잠재적인 예후 마커를 나타냅니다Original Article Published on 2021-12-202022-09-10 Journal: Metabolomics [Category] SARS, 바이오마커, 치료기술, [키워드] among others Analysis approach Bayesian Bayesian logistic regression model blind capture Cohort COVID-19 COVID-19 patient COVID-19 patient serum cross Deceased deoxycytidine diagnosis of COVID-19 discharged energy metabolism high resolution Hospital admission Host host inflammatory response host response include infected individual infected individuals Infection Kynurenine LC–MS/MS Orbitrap logistic regression model marker metabolism metabolite metabolites metabolomics Mild nucleic acid objective outcome Patient patient treatment Planning positive predict predicted Predictive predictor profile Prognostic marker property qualitative detection Result reveal ROC AUC ROC Curve selected serum severity statistical significance subset supplementary material Treatment UHPLC UHPLC-MS/MS uninfected control Untargeted metabolomics validation study Viral Viral load viral nucleic acid was performed [DOI] 10.1007/s11306-021-01859-3 PMC 바로가기 [Article Type] Original Article
Oncologists’ reflections on patient rights and access to compassionate use drugs: A qualitative interview study from an academic cancer center환자의 권리에 대한 종양 전문의의 반성 및 자비로운 사용 약물에 대한 접근 : 학술 암 센터의 질적 인터뷰 연구Research Article Published on 2021-12-172022-09-10 Journal: PLoS ONE [Category] 신약개발, 치료제, [키워드] Act amplify best Cancer center capture Care clinical trial clinical trials compassionate use discrepancies discrepancy drug Drug administration drugs Expanded access experimental drug Experimental drugs Factor FDA FDA approval FIVE food functional Functional status greater Health highlight illness institutional review board less Most patients myriad offered oncologist Oncologists optimism outlined participant pathway Patient physician Physicians PROTECT remained reported responsibility responsibility to protect Safe seeking shepherd the patient Treatment U.S. Food and Drug Administration [DOI] 10.1371/journal.pone.0261478 PMC 바로가기 [Article Type] Research Article
Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial InflammationSARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성Research Published on 2021-12-152022-09-10 Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured [DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research
Fusion of multi-scale bag of deep visual words features of chest X-ray images to detect COVID-19 infectionCovid-19 감염을 감지하기위한 흉부 X- 레이 이미지의 깊은 시각 단어 특징의 다중 규모 백 융합Article Published on 2021-12-132022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, [키워드] Accuracy Algorithm capture CD1 CD2 CD3 CD4 chest X-ray Chest X-ray image Computational biology and bioinformatics Convolution COVID-19 disease COVID-19 infection CXR dataset deep deep learning detect Diagnosis evaluate Experimental result experimental results feature Features fusion information Lungs Medical research Region shown support vector machine SVM the lungs a X-ray [DOI] 10.1038/s41598-021-03287-8 PMC 바로가기 [Article Type] Article
A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis콜드 체인 독립적인 표본 수집 및 운송 매체는 진단 감도를 개선하고 COVID-19 분자 진단의 생물학적 안전성 문제를 최소화합니다Research Article Published on 2021-12-082022-09-10 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] Accessibility adoption Asymptomatic biosafety bottleneck capture Care challenge Cold cold chain Collection Community contagious COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 testing COVID-19 transmission diagnostic diagnostic sensitivity diagnostics feasibility highlight identify inactivated India lack limit maintain medium microbial molecular Molecular diagnosis molecular diagnostics neutralize pandemic patients Prevent qPCR qRT-PCR quantitative PCR sample collection SARS-CoV-2 sensitivity significantly lower specimen specimen collection sustained symptomatic temperature threshold Transport transport medium unique unmet need urban population utility Viral Viral transmission Viral transport medium Virology virus VTM [DOI] 10.1128/Spectrum.01108-21 PMC 바로가기 [Article Type] Research Article