Personalizing ocrelizumab treatment in Multiple Sclerosis: What can we learn from Sars-Cov2 pandemic?다발성 경화증에서 ocrelizumab 치료 맞춤화: Sars-Cov2 대유행에서 무엇을 배울 수 있습니까?Article Published on 2021-08-152022-09-12 Journal: Journal of the neurological sciences [Category] MERS, SARS, 진단, [키워드] Active disease adopted CD19 Cell complete recovery COVID-19 Definitive effective response Efficacy help MRI Multiple multiple sclerosis naïve National observation period Ocrelizumab Patient patients treated predictor protocol recommendations risk Safety SARS-CoV-2 pandemic SARS-CoV2 SARS-CoV2 infection sclerosis severity the patient therapeutic window Treatment Two patient Vaccine was performed [DOI] 10.1016/j.jns.2021.117501 PMC 바로가기 [Article Type] Article
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy증례 보고서: CD19 CAR T 세포 치료 후 B 세포 결핍 환자의 회복기 혈장 치료 유도 항-SARS-CoV-2 T 세포 확장, NK 세포 성숙 및 바이러스 제거Case Reports Published on 2021-08-122022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activate B cell CAR CAR-T cell therapy CD19 CD19 CAR-T cell Cellular immune response Clinical studies convalescent plasma Convalescent plasma (CP) Convalescent plasma therapy coronavirus disease correlated COVID – 19 COVID-19 COVID-19 patients Deficient described expansion induced natural killer cell NK cell Patient SARS – CoV – 2 SARS-CoV-2 infections T cell the disease These data Treatment virus virus clearance virus-specific T cell [DOI] 10.3389/fimmu.2021.721738 PMC 바로가기 [Article Type] Case Reports
Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies혈액 학적 악성 종양 환자에서 SARS-COV-2 백신의 약한 면역 원성Article Published on 2021-08-102022-09-01 Journal: Blood Cancer Journal [Category] MERS, SARS, 진단, [키워드] ACE-2 Adaptive immunity anti-S anti-S IgG Anti-spike B-cell binding BNT162b2 BNT162b2 vaccine CD19 cellular response correlated correlation COVID-19 Cutoff effective evaluated Haematological cancer healthy controls Hematologic malignancy Hematological malignancies humoral IFN-γ IgG immune protection immunogenicity male multivariable analysis of BNT162b2 Patient patients Predictive Probability Protective S protein SARS-CoV-2 vaccine significant increase significantly Spearman T-cell Response the patient the S protein translate Translational research Treatment vaccination Vaccine [DOI] 10.1038/s41408-021-00534-z PMC 바로가기 [Article Type] Article
Effects of Steroids and Tocilizumab on the Immune Response Profile of Patients with COVID-19-Associated ARDS Requiring or Not Veno-Venous Extracorporeal Membrane OxygenationArticle Published on 2021-08-092022-10-31 Journal: Membranes [Category] COVID-19, [키워드] absence acute respiratory distress syndrome analyzed ARDS association B lymphocytes basophil both groups CD19 CD3 CD4 CD45 CD8 complicate concomitant therapy COVID-19 COVID-19 patient Critically ill drug ECMO Effect evaluate Extracorporeal extracorporeal membrane oxygenation immunomodulatory drugs increase in Inflammation Inflammatory leukocyte leukocytes lymphocyte lymphocyte subpopulation Lymphocytes lymphocytopenia marker Modification Monocytes Neutrophils NK cell Patient procalcitonin profile reduce reduced reducing reduction reduction in regression models required respiratory response SARS-CoV-2 pneumonia significantly steroid Steroids subpopulation Support Th cell therapy Tocilizumab trajectory Treatment VV-ECMO [DOI] 10.3390/membranes11080603 PMC 바로가기 [Article Type] Article
Characteristics of immune and inflammatory responses among different age groups of pediatric patients with COVID-19 in China중국에서 COVID-19를 가진 소아 환자의 다른 연령 그룹 사이에서 면역 및 염증 반응의 특성Original Article Published on 2021-08-022022-09-10 Journal: World Journal of Pediatrics [Category] MERS, SARS, 바이오마커, [키워드] age Age difference antibody B cell B cells C3c CD19 CD19+ Cell cell count children Children's Hospital China Clinical characteristics complement condition coronavirus disease Coronavirus disease 2019 Course COVID-19 demographic disease elevated evaluated group IgA IgM IL-6 immune immune cells Immunity Immunoglobulin Inflammation Inflammatory response information laboratory result Laboratory results Lactate lactate dehydrogenase less lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes marker Moderate COVID-19 Necrosis neutrophil Neutrophils Patient patients with moderate pediatric Pediatric patient Pediatric patients procalcitonin Recovery time recruited Result serum Severe case severe cases significantly significantly shorter supplementary material Symptoms Tumor tumor necrosis tumor necrosis factor while with COVID-19 Wuhan [DOI] 10.1007/s12519-021-00440-1 PMC 바로가기 [Article Type] Original Article
Ocrelizumab Extended Interval Dosing in Multiple Sclerosis in Times of COVID-19COVID-19 시기에 다발성 경화증에서 Ocrelizumab 연장된 간격 투여Observational Study Published on 2021-07-142022-09-11 Journal: Neurology® neuroimmunology & neuroinflammation [Category] 바이오마커, 임상, 진단, [키워드] accompanied association B-cell both groups CD19 class classification clinical clinical consequence clinical consequences Cohort control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic defined disability Disease activity dose Dosing Effectiveness evaluate evaluated Evidence evidence of Extended extended interval Follow-up in both group interquartile range interval Logistic regression median MRI multicenter cohort study Multiple multiple sclerosis multivariate multivariate logistic regression no evidence of Ocrelizumab pandemic Patient potential risk progression provide Relapsing-Remitting Multiple Sclerosis remained retrospective sclerosis stability standard interval Support time treatment regimen [DOI] 10.1212/NXI.0000000000001035 PMC 바로가기 [Article Type] Observational Study
Immune cell profiling and antibody responses in patients with COVID-19COVID-19 환자의 면역 셀 프로파일 링 및 항체 반응Research Article Published on 2021-07-052022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] Analysis antibody Antibody Response Antibody responses Antibody testing B cells blood cell CD19 CD20 CD4 CD8 Cell cells conducted COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients cross-sectional cross-sectional study evaluate flow cytometry group IgG IgG antibody IgG response IgM IgM and IgG IgM antibody IgM response Immune cell lymphocyte Lymphocyte count lymphocyte counts Lymphocyte subsets Lymphocytes median value neutrophil neutrophil count neutrophil counts Neutrophil-to-lymphocyte ratio NK cell NK cells no significant difference non-responder onset of symptoms P-value Patient patients with COVID-19 percentage percentages peripheral lymphocyte positive predictor produced Prognostic factor Prognostic factors Responder responders responses Result SARS-CoV-2 SARS-CoV-2 RT-PCR serological response significant difference significantly higher significantly increased significantly lower statistically significant study group subset suggested supplementary material T cell T cells T lymphocyte T lymphocytes the median the patient was performed were measured White blood cell [DOI] 10.1186/s12879-021-06278-2 PMC 바로가기 [Article Type] Research Article
Sex-based clinical and immunological differences in COVID-19Covid-19의 성별 기반 임상 및 면역 학적 차이Research Article Published on 2021-07-052022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] 95% confidence interval abnormality acute respiratory syndrome acute respiratory syndrome coronavirus adjusted hazard ratio Analysis antibody Antibody Response B cell B cells CD19 CD19+ CD4+ T cell CD4+ T cells change chemiluminescence clinical outcomes Clinical practice close monitoring Comparative analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients Cytokines Cytometry death disease course female female patient Female patients females Flow flow cytometry gradually increased Hospitalization ICU admission IgG level IgG levels immune cells immunological Immunological response immunology independent risk factor indolent Inflammation Inflammatory cytokine Inflammatory cytokines lymphocyte lymphocyte subgroup lymphocyte subgroups Lymphocyte subset Lymphocyte subsets Lymphocytes male Male sex medical intervention Mortality nucleoprotein Pathogens Patient patients performed Peripheral blood Prognosis Protective Protein RBD-specific IgG reached Receptor binding domain renal respiratory Result SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex single center specific IgM spike Spike protein supplementary material survival analysis symptom onset T cells the disease Trial were measured [DOI] 10.1186/s12879-021-06313-2 PMC 바로가기 [Article Type] Research Article
A systematic meta-analysis of immune signatures in patients with COVID-19COVID-19 환자의 면역 신호에 대한 체계적인 메타 분석Meta-Analysis Published on 2021-07-012022-09-12 Journal: Reviews in Medical Virology [Category] SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody B cell B cells basophil Biomarker can be used CD16 CD19 CD25 CD3 CD4 CD56 CD8 Combination coronavirus COVID-19 Cytokines disease disease severity eosinophil evaluated IgA IgE IgG antibody IgM antibody IL-10 IL-1β IL-4 IL-5 IL-6 IL-8 immune signature immunological Innate immunity interleukin Meta-analysis Monocytes Necrosis Neutrophils NK cell NK cells non-severe group non-severe patient non-severe patients outcome Patient patients with COVID-19 predict predictor robust SARS-CoV-2 SARS-COV-2 infection Serum level severe group Severe patient severe patients significantly significantly higher T cell T cells Transmission Treg up-regulated [DOI] 10.1002/rmv.2195 PMC 바로가기 [Article Type] Meta-Analysis
Transient disappearance of CD19 + /CD5 + B‐lymphocyte clone in peripheral blood in a patient with CLL during SARS‐CoV‐2‐related mild diseaseCase Report Published on 2021-06-222022-11-01 Journal: Clinical Case Reports [Category] COVID-19, [키워드] CD19 CD19+/CD5+ clone clinical marker CLL clone COVID‐19 disease evaluated Lymphocytic leukemia lymphopenia Mild Patient Peripheral blood Prognosis SARS‐CoV‐2 to define Transient Treatment [DOI] 10.1002/ccr3.4238 PMC 바로가기 [Article Type] Case Report